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Chemistry World August 15, 2011 Simon Hadlington |
Trifluoromethylation Made Easy US researchers have discovered a simple, low-cost way to add fluorine atoms to heteroaromatic rings.  |
Chemistry World March 24, 2015 Karl Collins |
Back to basics for silylation While silicon is probably most familiar in organic synthesis as part of protecting groups, its utility extends much further.  |
Chemistry World January 23, 2012 James Urquhart |
Simple One Stop Shop for Difluoromethylation A new process developed by researchers opens the way for adding difluoromethyl (CF 2H) groups to drugs and agrochemicals in order to enhance their properties.  |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions.  |
Chemistry World June 24, 2010 Phillip Broadwith |
Aryl rings get a fluorine fix A mild and effective method for coupling trifluoromethyl groups on to aryl rings has been developed by US chemists.  |
Chemistry World January 14, 2015 Karl Collins |
Alkynes reverse reactivity Coupling together thiols and alkynes -- both inherently nucleophilic species -- is a tricky prospect.  |
Chemistry World April 18, 2012 Elinor Richards |
Homogeneous Catalyst Recovery Made Easier Scientists have now found a way to recover homogeneous catalysts at the end of a chemical reaction that doesn't suffer from the slow reaction rates that affect current catalyst recovery systems.  |
Chemistry World February 20, 2012 James Urquhart |
Unusual kinetics of catalyst revealed US researchers have elucidated the unusual reaction kinetics of C-H activation by the palladium(II) catalyst (Pd(OAc) 2).  |
Chemistry World April 12, 2012 Simon Hadlington |
Recruiting electrophiles for organic cross-coupling Chemists in the US have taken an unconventional approach to carbon cross-coupling and in doing so have potentially opened the door to the rapid and efficient synthesis of a wide range of organic compounds.  |
Chemistry World July 3, 2014 Phillip Broadwith |
Show the way but leave no trace Recent efforts to develop efficient methods to isolate phenols from biomass mean they may become an increasingly attractive, environmentally sustainable, synthesis feedstock  |
Chemistry World August 16, 2009 Tom Bond |
Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis.  |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.  |
Chemistry World March 19, 2009 Manisha Lalloo |
Copper catalysts give meta aromatics UK Researchers have discovered that, simply by using a copper catalyst, they are able to perform tricky substitution reactions at a difficult position on benzene rings  |
Chemistry World December 6, 2012 Simon Hadlington |
Chemists crack fluoroform challenge US scientists appear to have cracked a long-standing problem in organofluorine chemistry -- how to find a simple and efficient way to use the low-cost and abundant compound fluoroform as a trifluoromethylation agent.  |
Chemistry World August 12, 2015 Matthew Gunther |
Chemists hold a candle to reagent preservation Scientists in the US now have a solution to end the build-up of chemical waste with a wax capsule that can protect reagents from the atmosphere.  |
Chemistry World November 2010 |
Carbon Couplers Take the Prize Three giants of organic chemistry, who pioneered palladium-catalysed cross coupling reactions, have shared this year's Nobel prize.  |
Chemistry World December 17, 2009 Simon Hadlington |
Single catalyst gives two products from racemic mixture Chemists in the US have demonstrated a remarkable reaction in which a single catalyst can transform a racemic mixture - molecules identical in every way except for their chirality - into two distinct enantiomerically pure products.  |
Chemistry World December 5, 2012 Phillip Broadwith |
Chemical reactions in hot water Chinese and Japanese chemists have highlighted hot water's ability to promote unexpected reactions without any other reagents or catalysts. The work should expand our understanding of how to harness the physicochemical properties of water to potentially replace more complex reagents and catalysts.  |
Chemistry World January 17, 2014 Katia Moskvitch |
Life may have begun in a tiny water droplet Chemical reactions run much faster and more efficiently when they take place in tiny droplets rather than in freestanding water -- such as a puddle or a lake, say researchers.  |
Chemistry World August 30, 2009 Phillip Broadwith |
C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules.  |
Chemistry World December 20, 2007 Richard Van Noorden |
Off-the-Peg Organic Synthesis Goes Commercial Chemists have created an efficient way to make small molecules by repeatedly using just one coupling reaction to clip together pre-prepared chemical fragments is going commercial.  |
Chemistry World June 12, 2015 David Bradley |
Copper click chemistry mechanism unravelled Both the mono- and bis-copper pathways are active in the CuAAC reaction, but the latter is kinetically favored.  |
Chemistry World December 8, 2011 Sarah Farley |
Capturing Compounds in Cages for Chemical Control Scientists from the UK have used a molecular capsule to control the reactivity of an organic compound.  |
Chemistry World December 14, 2012 Jon Cartwright |
Pico-gold clusters break catalysis record Chemists in Spain have shown that small clusters of gold atoms are excellent inorganic catalysts with record-breaking efficiency.  |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?  |
Chemistry World February 21, 2007 Tom Westgate |
Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules.  |
Chemistry World January 13, 2011 Sarah Corcoran |
Unclogging the problems of flow chemistry US scientists have found a way to stop solid byproducts clogging channels in continuous flow reactors, a problem that has hampered their progress for use in manufacturing pharmaceuticals.  |
Chemistry World July 16, 2009 Simon Hadlington |
Strange vibrations Researchers in Taiwan have shown that in a relatively simple molecular system the induced vibrations can inhibit the breaking of the bond and slow the reaction down.  |
Chemistry World April 4, 2013 Phillip Broadwith |
A solution to fluoronium riddle The first evidence for hypervalent fluorine cations, or fluoronium ions, in solution has been found by US chemists.  |
Chemistry World September 20, 2007 Lewis Brindley |
New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction.  |
Chemistry World June 16, 2011 |
Forming the First Sugars with Formose Reactions Hydrothermal synthesis could provide greener synthesis methods as well as information about the origin of life.  |
Chemistry World December 2, 2008 James Mitchell Crow |
Just add air for cleaner carbon bonding UK scientists have found a new way to clip together organic molecules that could be the ultimate green approach to making carbon-carbon bonds  |
Chemistry World August 14, 2014 Elisabeth Ratcliffe |
Photoredox route to medically-important heterocycles Researchers in the US have developed a new photo catalyzed coupling reaction that could provide a pathway to a huge number of biologically active compounds.  |
Chemistry World June 2011 |
Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan.  |
Chemistry World March 8, 2009 Nina Notman |
Polymer Crossroads Act as Tiny Reactors Scientists in the US have taken inspiration from a Dutch painter to create ultrasmall chemical reactors at the junctions of overlapping polymer nanofibres  |
Chemistry World October 15, 2012 Melissae Fellet |
Synthesis by mass spectrometry Chemists have used mass spectrometry, commonly used to analyze molecules, to synthesize them on the microscale.  |
Chemistry World April 10, 2008 Mark Peplow |
'Pot-in-a-Pot' Technique Makes Impossible Cascade Reactions Easy A simple technique that nests a series of reaction vessels could help chemists avoid the tedium and expense of purifying organic compounds after each step of a long synthesis.  |
Chemistry World December 16, 2011 Kate McAlpine |
Radical experiment assesses interstellar nitrogen Radical reactions are challenging to measure at cold temperatures, but an international team of researchers have recently clocked the rate for atomic nitrogen and hydroxyl radicals at 56K.  |
Chemistry World February 2, 2012 Elinor Richards |
Magical microwaves Microwaves have been used to promote organic reactions since the 1980s and they can lead to higher yields and shorter reaction times than conventional heating, but why?  |
Chemistry World August 24, 2010 Lewis Brindley |
A better way to add radioactive fluorine Making compounds that contain the useful radioisotope fluorine-18 ( 18F) could be much easier in future, say researchers in the UK and Finland.  |
Chemistry World February 22, 2008 James Mitchell Crow |
Rhodium Fast Tracks Route to Lactones Chemists in Canada have developed an efficient new way to make lactones, chemical components of many natural products and drugs.  |
Chemistry World September 4, 2008 Fred Campbell |
Two catalysts better than one US researchers have cracked a long standing problem in chemical synthesis - the catalytic alpha-alkylation of aldehydes - by combining two catalysts in one pot.  |
Chemistry World July 27, 2009 Simon Hadlington |
Peer review by live blogging Blogging can immediately bring together expert opinion on a given topic. Poorly reviewed papers claiming novelty can be expected to be rapidly dissected in the blogosphere, as some chemists have found out.  |
Chemistry World July 15, 2010 Simon Hadlington |
Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit.  |
Chemistry World September 29, 2015 |
Navigating chemical space How big is chemistry? I don't mean how important is it, or how many people do it, but rather, how many molecules are there that we could make?  |
Chemistry World November 3, 2011 David Bradley |
Faster Synthesis of Fluorine Radioisotope Imaging Agents A palladium-containing fluorination reagent can be used to quickly synthesise aromatic molecules labelled with fluorine-18, a positron emitter used in molecular imaging.  |
Chemistry World August 22, 2014 Derek Lowe |
Death of a reagent Anyone who's been practicing organic chemistry for a while can think back to reactions and reagents that were once in far wider use than they are today.  |
Chemistry World April 2010 Paul Docherty |
Column: Totally Synthetic When one attempts the first synthesis of a natural product, the set of challenges are often unknown; which intermediates are either inaccessible or unstable, for instance.  |
Chemistry World June 18, 2009 Lewis Brindley |
Chemical speed-dating even faster Researchers in the US have adapted a DNA amplification technique to develop a simpler way to rapidly screen chemical reactions.  |
Chemistry World April 30, 2008 Lewis Brindley |
Chemical compass clue to migration mystery Trying to identify the mysterious innate compass that many animals use to navigate the globe, chemists at the University of Oxford, UK, have shown for the first time that the Earth's magnetic field can influence the outcome of a chemical reaction.  |