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Chemistry World August 16, 2009 Tom Bond |
Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis.  |
Chemistry World August 15, 2011 Simon Hadlington |
Trifluoromethylation Made Easy US researchers have discovered a simple, low-cost way to add fluorine atoms to heteroaromatic rings.  |
Chemistry World October 22, 2008 Susan Aldridge |
A greener route to amines Researchers based in Israel have developed an easier way to make troublesome primary amines, using a new ruthenium catalyst.  |
Chemistry World April 11, 2014 |
The sultan of synthesis Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers  |
Chemistry World February 27, 2012 Phillip Broadwith |
Bending carbonyl reactivity rules Belgian chemists have uncovered a method to bypass the standard reactivity hierarchy of carbonyl compounds, allowing a ketone or ester to be reduced in the presence of a more reactive aldehyde.  |
Chemistry World July 3, 2015 Andy Extance |
Copper catalysis overcomes double bond trouble Some carbon-carbon double bonds seem too unreactive for synthetic use -- but that's just how chemists in the US are now exploiting them.  |
Chemistry World September 18, 2015 Tim Wogan |
Shining a light on amine synthesis A new method for site selective amination of aromatic organic compounds has been developed by researchers in the US.  |
Chemistry World August 14, 2014 Elisabeth Ratcliffe |
Photoredox route to medically-important heterocycles Researchers in the US have developed a new photo catalyzed coupling reaction that could provide a pathway to a huge number of biologically active compounds.  |
Chemistry World July 9, 2012 Phillip Broadwith |
'Molecular cobra' turns C-H to C=C A reagent developed by US chemists can selectively introduce synthetically useful C=C double bonds into unactivated carbon chains, guided by an activating group attached to a nearby oxygen or nitrogen atom.  |
Chemistry World November 2010 |
Carbon Couplers Take the Prize Three giants of organic chemistry, who pioneered palladium-catalysed cross coupling reactions, have shared this year's Nobel prize.  |
Chemistry World March 24, 2015 Karl Collins |
Back to basics for silylation While silicon is probably most familiar in organic synthesis as part of protecting groups, its utility extends much further.  |
Chemistry World August 1, 2013 James Urquhart |
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions.  |
Chemistry World February 2010 Paul Docherty |
Column: Totally Synthetic Palau'amine is an alkaloid which has stubbornly held off synthesis for over 15 years. Its nemesis comes in the form of Phil Baran at the Scripps Research Institute, La Jolla, US.  |
Chemistry World March 21, 2007 Alison Stoddart |
Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products.  |
Chemistry World January 23, 2012 James Urquhart |
Simple One Stop Shop for Difluoromethylation A new process developed by researchers opens the way for adding difluoromethyl (CF 2H) groups to drugs and agrochemicals in order to enhance their properties.  |
Chemistry World February 13, 2013 James Mitchell Crow |
Tapping proton power for enantioselective synthesis A simple proton is the key to a novel approach by US-based chemists to synthesize chiral amines and alcohols -- a structural motif common to many organic molecules with pharmaceutical promise.  |
Chemistry World September 4, 2008 Fred Campbell |
Two catalysts better than one US researchers have cracked a long standing problem in chemical synthesis - the catalytic alpha-alkylation of aldehydes - by combining two catalysts in one pot.  |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions.  |
Chemistry World October 12, 2015 Emma Stoye |
Chemistry Nobel laureate Richard Heck dies Richard Heck, the organic chemist who shared the 2010 chemistry Nobel prize with for developing palladium-catalyzed cross coupling reactions, has died aged 84.  |
Chemistry World June 10, 2010 Simon Hadlington |
Elusive intermediate snared Chemists in Germany have succeeded in trapping an elusive intermediate involved in a key synthetic reaction catalysed by an organic molecule.  |
Chemistry World August 11, 2010 Simon Hadlington |
Non-metal-catalysed C-C coupling Chinese chemists have successfully coupled aromatic molecules without the use of a transition metal catalyst - something that people have been trying to do for years with little success.  |
Chemistry World April 12, 2012 Simon Hadlington |
Recruiting electrophiles for organic cross-coupling Chemists in the US have taken an unconventional approach to carbon cross-coupling and in doing so have potentially opened the door to the rapid and efficient synthesis of a wide range of organic compounds.  |
Chemistry World July 20, 2006 Jessica Ebert |
Golden Touch for Amines Aminobenzene chemicals are used to make anything from dyes to pharmaceuticals, and now scientists have found a way to produce them in a more efficient way using a gold catalyst.  |
Chemistry World August 22, 2014 Derek Lowe |
Death of a reagent Anyone who's been practicing organic chemistry for a while can think back to reactions and reagents that were once in far wider use than they are today.  |
Chemistry World September 2011 Paul Docherty |
Column: Totally Synthetic Corey Stephenson of Boston University is an expert a type of reaction called photochemical reduction-oxidation. He has charmed photons into performing many chemical tricks, but one is a photoredox dehalogenation using blue light and a ruthenium bipyridyl catalyst.  |
Chemistry World June 2011 |
Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan.  |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?  |
Chemistry World September 23, 2013 Karl Collins |
The portable chemist's consultant The portable chemist's consultant from Phil Baran's laboratory at the Scripps Research Institute in California challenges the concept of a 'textbook' by providing a progressive, multimedia textbook application. This is the future of scientific textbooks.  |
Chemistry World January 13, 2011 Sarah Corcoran |
Unclogging the problems of flow chemistry US scientists have found a way to stop solid byproducts clogging channels in continuous flow reactors, a problem that has hampered their progress for use in manufacturing pharmaceuticals.  |
Chemistry World September 2, 2013 Paul Docherty |
Steviol A discussion is presented on new ways to synthesize the diterpenoid steviol.  |
Chemistry World December 3, 2009 Simon Hadlington |
C-H Bond Activation Takes the Relaxing Route Chemists have uncovered a key factor that helps determine the reactivity of a C-H bond to oxidation.  |