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Chemistry World December 10, 2008 Simon Hadlington |
Alcohol enantiomer conundrum cracked UK chemists have discovered a straightforward new way to make chiral tertiary alcohols that gives selective access to either enantiomer.  |
Chemistry World January 27, 2010 Simon Hadlington |
Fruity route to control asymmetric syntheses Chemists in the UK have discovered a quick, cheap and easy way to make a key sulfide reagent that can mediate the formation of chirally selective molecules needed for complex organic syntheses.  |
Chemistry World June 8, 2014 David Bradley |
Carbon--carbon couplings go 3D Chemists have devised a new stereospecific coupling reaction for electron-rich aromatics using secondary and tertiary boronic esters that works under mild conditions.  |
Chemistry World February 21, 2007 Tom Westgate |
Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules.  |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?  |
Chemistry World February 19, 2010 Simon Hadlington |
Forcing stereoselectivity on reactive cations Chemists in the US have devised a dual catalyst strategy to tame the highly reactive iminium ion to give a high degree of stereochemical control over subsequent reactions of the ion.  |
Chemistry World December 17, 2009 Simon Hadlington |
Single catalyst gives two products from racemic mixture Chemists in the US have demonstrated a remarkable reaction in which a single catalyst can transform a racemic mixture - molecules identical in every way except for their chirality - into two distinct enantiomerically pure products.  |
Wired Erin Biba |
Molecular Frameworks, the Building Blocks of All Life The world is complicated, but not as complicated as you might think. Most organic molecules derive from a few relatively simple architectures.  |
Chemistry World March 2012 |
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug  |
Chemistry World September 29, 2015 |
Navigating chemical space How big is chemistry? I don't mean how important is it, or how many people do it, but rather, how many molecules are there that we could make?  |
Chemistry World September 20, 2007 Lewis Brindley |
New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction.  |
Technology Research News June 29, 2005 |
Self-assembly: the natural way to make things In biology, there are a few different ways DNA molecules can be replicated and combined.  |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.  |
Chemistry World June 2008 Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success  |
Chemistry World July 19, 2010 Phillip Broadwith |
Designing porous patterns Belgian chemists are finally getting to grips with how to control the way molecules arrange themselves at the solid-liquid interface.  |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve.  |
Chemistry World March 25, 2011 Simon Hadlington |
New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists.  |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions.  |
Chemistry World July 31, 2008 |
Nanostructures Made Easy Scotland-based chemists have invented a new way to build nanoscale arrays of molecules over a large surface area: a technique that may be key to making nanostructures in sophisticated sensors, catalysts, and tiny computer parts.  |
Reactive Reports Issue 63 David Bradley |
Natural Copy Cat While plants convert carbon dioxide into sugar and oxygen, chemists are having a more difficult time finding an efficient method for converting carbon dioxide into useful fuels.  |
Chemistry World December 20, 2007 Richard Van Noorden |
Off-the-Peg Organic Synthesis Goes Commercial Chemists have created an efficient way to make small molecules by repeatedly using just one coupling reaction to clip together pre-prepared chemical fragments is going commercial.  |
Chemistry World February 2011 |
Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential  |
Chemistry World March 21, 2007 Richard Van Noorden |
Forcing a Reaction US chemists have forced molecules to react by ripping their bonds apart with ultrasound. The scientists carefully stretched one targeted bond until it snapped, guiding the molecule's subsequent reaction into pathways forbidden by conventional chemistry.  |
Chemistry World September 6, 2013 Melissae Fellet |
Unravelling stereochemistry via mass spectrometry Researchers have used mass spectrometry to determine the stereochemistry of a prototypical chiral molecule, CHBrClF.  |
Chemistry World December 2008 |
Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project.  |
Chemistry World March 22, 2012 Ross McLaren |
Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule.  |
Chemistry World March 9, 2006 Katharine Sanderson |
Covalent Bonds Crack Under the Strain Chemists must consider engineering principles when designing molecules following news that tough carbon-to-carbon bonds break easily under mechanical strain.  |
Chemistry World March 2, 2011 Sarah Corcoran |
Natural products go with the flow Technology that could bring flow chemistry into the domain of complex natural product synthesis has been developed by UK scientists.  |
Chemistry World July 2007 Dylan Stiles |
Opinion: Bench Monkey Synthesizing molecules that force atoms into bizarre contortionist acts is the only way to learn.  |
Chemistry World September 6, 2010 Phillip Broadwith |
Are you sure that structure is right? UK chemists have developed a computer program that can work out how likely a chemical structure is to be correct, or identify the right structure from a range of possibilities.  |
Reactive Reports David Bradley |
Subjective Suboxide Carbon monoxide and carbon dioxide are probably the best known molecules containing just carbon and oxygen, but they do form others, such as carbon suboxide (C3O2), which is one of the most stable.  |
Chemistry World September 24, 2014 Hayley Simon |
Water provides new angle on single molecule imaging Small variations in a molecule's conformation can have a large effect on chemical reactivity. Being able to identify these differences is one of the aims of high resolution spectroscopy.  |
Chemistry World November 27, 2012 Paul Docherty |
Pentalenolactone A methyl ester One team that really gets the Pauson -- Khand reaction or the PKR and all its nuances is that led by Zhen Yang at Peking University in Beijing, China. They recently published a very neat synthesis of the intricate pentalenolactone  |
Chemistry World June 2008 Philip Ball |
The Crucible By investigating how far a carbon vertex can be bent before it spontaneously flies apart, chemists can gain some understanding of the parameters within which such frameworks must operate.  |
Chemistry World October 1, 2012 Paul Docherty |
Prostaglandin F2I There's been no shortage of grant funding for synthetic chemistry of the prostaglandins, keeping some of the finest minds in organic chemistry engaged over the last five decades.  |
Chemistry World August 29, 2012 Paul Docherty |
Amphidinolide F We're plunging into the marine depths to find natural products with prodigious biological activity. The amphidinolide family comprises over 30 members, varying in architecture but (almost) all featuring a complex and highly decorated macrolactone ring at the core.  |
Chemistry World February 8, 2006 Jon Evans |
To Boldly go Where no Chemist Has Gone Before Studying the interactions between different molecular fragments is taking researchers to the uncharted regions of chemical space.  |
Chemistry World August 16, 2009 Tom Bond |
Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis.  |
HHMI Bulletin Nov 2011 Sarah C. P. Williams |
Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems.  |
IndustryWeek April 1, 2009 David Blanchard |
'Green' Supply Chain Movement Very few companies are actively pursuing sustainability initiatives.  |
Chemistry World May 20, 2015 Katrina Kramer |
Molecules that amaze us For chemistry-savvy readers, the book is an enjoyable, easy-to-digest collection of fascinating molecules to dip in and out of.  |
Chemistry World October 12, 2011 Joanne Thomson |
Hot Chemistry Temperature played a crucial role in David MacMillan's decision to study chemistry.  |
Technology Research News March 23, 2005 |
Nanowires track molecular activity Researchers from Harvard University have found a way to use transistors made from silicon nanowires to gain information about how small molecules bind to proteins.  |