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Chemistry World
March 27, 2013
Akshat Rathi
Molecular cages to end crystallization nightmare X-ray crystallography has shaped modern chemistry. It is a powerful tool for molecular structural analysis. But it suffers from one big drawback: it can only analyze materials that form well-defined crystals. This may now be about to change. mark for My Articles similar articles
HHMI Bulletin
Spring 2013
Nicole Kresge
A Structural Toolbox Natalie Strynadka wants to design a better antibiotic. Her strategy: learn about the molecules bacteria use to invade cells. Her tool: structural biology. mark for My Articles similar articles
Chemistry World
October 17, 2011
Andy Extance
Water erodes 'lock and key' drug model US researchers have dealt a severe blow to the idea of a single 'hydrophobic effect' that can help explain how all drugs dock with proteins. mark for My Articles similar articles
Chemistry World
July 15, 2014
Richard Cooper
Phasing in crystallography: a modern perspective Phasing in crystallography has its origins in Carmelo Giacovazzo's monograph Direct phasing in crystallography, but with a broader coverage of the range of modern phasing methods. mark for My Articles similar articles
Chemistry World
June 2010
Column: The crucible Philip Ball welcomes the age of automated chemical crystallography mark for My Articles similar articles
Chemistry World
October 2008
Derek Lowe
Column: In the pipeline The author seeks a cure for 'compound bloat' mark for My Articles similar articles
Chemistry World
December 5, 2012
Neil Withers
We don't need no intuition US scientists have developed a way to solve crystal structures that combines powerful computational methods with data from experiments or databases -- but that does not require much human input. mark for My Articles similar articles
Chemistry World
March 19, 2013
Ilia Guzei
OLEX2 v1.2.1 OLEX2 is a program for small-molecule structure solution, refinement and the preparation of publication material in the field of single-crystal x-ray crystallography. mark for My Articles similar articles
Chemistry World
September 6, 2010
Phillip Broadwith
Are you sure that structure is right? UK chemists have developed a computer program that can work out how likely a chemical structure is to be correct, or identify the right structure from a range of possibilities. mark for My Articles similar articles
HHMI Bulletin
Winter 2013
Nicole Kresge
A Structural Revolution Over the years, scientists and artists have used an assortment of techniques to showcase molecular structure. mark for My Articles similar articles
Chemistry World
February 13, 2014
Philip Ball
Ice core to antifreeze protein's inner workings The antifreeze protein that protects the winter flounder from sub-zero temperatures has been found to have an odd structure. mark for My Articles similar articles
Chemistry World
June 12, 2013
Kirsty Muirhead
An end to chasing molecules that were never there? Ariel Sarotti from the Rosario National University, Argentina, has developed a new, computationally inexpensive method combining calculated and experimental 13C NMR data to flag up incorrect structures. mark for My Articles similar articles
Reactive Reports
Issue 51
David Bradley
Protein Crystals Trapped Researchers have developed a new technique for crystallizing proteins, which could open up a whole range of materials to this powerful analytical technique. mark for My Articles similar articles
Bio-IT World
November 19, 2004
Kevin Davies
De-Lovely Pharmaceuticals De Novo Pharmaceuticals identifies novel compounds right before your eyes. mark for My Articles similar articles
Chemistry World
August 2007
Derek Lowe
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. mark for My Articles similar articles
Bio-IT World
October 10, 2003
Jeffrey Skolnick
Protein Structure Prediction in Drug Discovery Indications are that structure prediction can assist in the automated assignment of proteins to known pathways. mark for My Articles similar articles
Chemistry World
August 1, 2010
Mike Brown
Snapshots of mystery molecular structures Researchers have used atomic force microscopy to produce clear molecular images that can help determine the correct atomic structure of unknown organic molecules. mark for My Articles similar articles
Chemistry World
October 6, 2015
Colin Groom
A story of structure For chemists, the Cambridge Structural Database is part of the furniture. It contains data for every small molecule crystal structure ever determined -- over 750,000 of them mark for My Articles similar articles
Chemistry World
April 2007
Derek Lowe
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort? mark for My Articles similar articles
Bio-IT World
October 9, 2002
Tracy Smith Schmidt
Banking on Structures An explosion of structural information is on the horizon, and the Protein Data Bank --- the single international repository for data on the three-dimensional structures of biomolecules -- is ready. mark for My Articles similar articles
Chemistry World
November 30, 2007
Lewis Brindley
Crystal Clear Structure Prediction One team of researchers has hit the jackpot by correctly predicting the crystal structures of four organic molecules in a competition organized by the University of Cambridge. mark for My Articles similar articles
Chemistry World
December 5, 2007
Ananyo Bhattacharya
Structural Snapshot Shows Monster Protein A structural snapshot of a protein capsule has revealed details of the largest cellular component ever imaged by x-ray crystallography. mark for My Articles similar articles
Chemistry World
November 7, 2012
Ian Le Guillou
Coral animal chemical structures solved A combination of atomic force microscopy and computational techniques have been used to solve the unusual structures of two natural products from the Arctic coral-like animal, Thuiaria breitfussi. mark for My Articles similar articles
Reactive Reports
Issue 63
David Bradley
Chemists Go Round the Bend Chemists often think of molecular wires as "shape-persistent" rods with limited flexibility, but researchers have now shown that molecular wires can be bent into ring shapes. mark for My Articles similar articles
Chemistry World
December 2008
Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project. mark for My Articles similar articles
Industrial Physicist Biomimetic Nanotechnology Although biomimetic nanotechnology is in its infancy, with no applications yet reaching commercialization, the barriers in some cases lie mainly in scaling up production processes to industrial levels. mark for My Articles similar articles
Chemistry World
May 2, 2007
Michael Gross
Protein Printboard Chemists in the Netherlands have created nanoscale structures that can immobilize proteins with exquisite control over specificity, strength and orientation. mark for My Articles similar articles
Bio-IT World
June 12, 2002
Karen Hopkin
Computational Biologists Join the Fold CASP5 competitors compare the best algorithms for modeling the 3-D structure of proteins -- an exercise that could lead to new insights into the pathogenesis and treatment of disease. mark for My Articles similar articles
Chemistry World
September 30, 2009
Simon Haddlington
Porous networks trap reactive intermediates Chemists in Japan have shown how it is possible to take sequential x-ray snapshots of chemical reactions taking place within molecular-sized 'reaction chambers', capturing the crystal structures of short-lived reactive intermediates. mark for My Articles similar articles
Chemistry World
July 26, 2012
Derek Lowe
Screen shots You might not think that the makeup of a compound screening collection could set off many arguments, but there are a few issues there that will do the trick almost every time. mark for My Articles similar articles
Reactive Reports
Apr/May 2005
David Bradley
At Last, the Structure of DNA Researchers have made a significant advance in our understanding of life's main molecule, using X-ray crystallography to determine the three-dimensional structures of nearly all the possible sequences of a macromolecule. mark for My Articles similar articles
Chemistry World
February 8, 2006
Jon Evans
To Boldly go Where no Chemist Has Gone Before Studying the interactions between different molecular fragments is taking researchers to the uncharted regions of chemical space. mark for My Articles similar articles
Chemistry World
November 14, 2014
Laura Fisher
Will it crystallize? Scientists have developed a machine learning approach to predict whether a small organic molecule will be able to crystallize. mark for My Articles similar articles
Chemistry World
August 2009
Derek Lowe
Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder mark for My Articles similar articles
Chemistry World
August 25, 2011
Fiona McKenzie
Poking Aspirin with a Sharp Stick Scientists have found a way to go one better than x-ray crystallography to examine pharmaceutical crystals at an even deeper level. mark for My Articles similar articles
Chemistry World
October 31, 2014
X marks the structure From single crystals to powders and even proteins, there's a diffractometer for every structure. mark for My Articles similar articles
Chemistry World
June 1, 2012
Derek Lowe
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that. mark for My Articles similar articles
Chemistry World
June 2008
Sarah Houlton
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success mark for My Articles similar articles
Chemistry World
May 20, 2014
Andy Extance
Mechanism study seeks to clear 'crystalline flask' cloud The Japanese chemists behind a controversial x-ray crystallography method have used it to study a poorly-understood reaction mechanism for the first time. mark for My Articles similar articles
Chemistry World
January 17, 2007
Richard Van Noorden
Molecular Magnets of Mystery Researchers have discovered a new class of molecular magnets which work above room temperature. But why the magnets work, and what their structures are, remains a perplexing mystery. mark for My Articles similar articles
Chemistry World
June 23, 2015
Philip Ball
Ultra-bright x-rays film molecular reaction A team working at the Stanford Linear Collider in California claims to have made 'the first molecular movie' using ultra-fast x-ray scattering from molecules as they undergo a chemical reaction. mark for My Articles similar articles
Chemistry World
July 3, 2014
Tami Spector
Of atoms and aesthetics Molecular aesthetics means many things to a few people. For some it means tangible aspects of compounds; for others yet, the ways that chemists represent molecules. mark for My Articles similar articles
Chemistry World
April 30, 2007
Victoria Gill
Amyloid Protein Seen to Zip Together Amyloid proteins' long, complicated structure makes them tricky to study, but U.S. researchers have found that they share a common feature that could provide a drug target for an array of incurable conditions. mark for My Articles similar articles
Chemistry World
March 4, 2015
Philip Ball
Program ready to weed out tough drug leads A method for reliably predicting how well a candidate drug molecule will bind to its target receptor would allow libraries of molecules to be screened on the computer, without having to synthesize them all. mark for My Articles similar articles
Chemistry World
June 23, 2015
Derek Lowe
Missing the target There are enzymes that no mustard has ever cut, to steal a phrase from science fiction author James Blish. Phosphatases, the flip side of kinase activity, are a perfect example. mark for My Articles similar articles
Chemistry World
October 27, 2014
Tim Wogan
Folding rules used to build unnatural proteins Scientists in the UK and US have designed and synthesized unnatural protein structures, using theoretical calculations to explore the factors affecting protein folding and stability. mark for My Articles similar articles
Chemistry World
December 2007
Derek Lowe
Column: In the Pipeline The challenge of biologics. mark for My Articles similar articles
Bio-IT World
June 12, 2002
Mark D. Uehling
Putting Proteins in Their Place Will a 'periodic table' of proteins help classify the ungainly beasts? mark for My Articles similar articles
Chemistry World
July 6, 2012
Protein power Tom Muir, professor of chemistry and molecular biology, Princeton University, US, is an expert in protein engineering and its application to studying cellular signalling networks. mark for My Articles similar articles
Chemistry World
June 2008
Column: In the pipeline The author, a medicinal chemist working on preclinical drug discovery, takes a look at the differences between chemists and biologists working on the same team. mark for My Articles similar articles