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Chemistry World
August 1, 2013
James Urquhart
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions. mark for My Articles similar articles
Chemistry World
March 21, 2007
Alison Stoddart
Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products. mark for My Articles similar articles
Chemistry World
July 9, 2012
Phillip Broadwith
'Molecular cobra' turns C-H to C=C A reagent developed by US chemists can selectively introduce synthetically useful C=C double bonds into unactivated carbon chains, guided by an activating group attached to a nearby oxygen or nitrogen atom. mark for My Articles similar articles
Chemistry World
November 3, 2008
Simon Hadlington
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? mark for My Articles similar articles
Chemistry World
August 2007
Derek Lowe
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. mark for My Articles similar articles
Chemistry World
August 15, 2011
Simon Hadlington
Trifluoromethylation Made Easy US researchers have discovered a simple, low-cost way to add fluorine atoms to heteroaromatic rings. mark for My Articles similar articles
Chemistry World
February 2010
Paul Docherty
Column: Totally Synthetic Palau'amine is an alkaloid which has stubbornly held off synthesis for over 15 years. Its nemesis comes in the form of Phil Baran at the Scripps Research Institute, La Jolla, US. mark for My Articles similar articles
Chemistry World
November 2007
Dylan Stiles
Column: Bench Monkey Total synthesis is not immune to the vagaries of fickle fashion. mark for My Articles similar articles
Chemistry World
May 22, 2015
James Urquhart
Complex amines made easy (and cheap) Phil Baran's lab at the Scripps Research Institute, La Jolla, has come up with a protocol that repurposes two readily available and inexpensive feedstock building blocks; olefins and nitroarenes, via iron-catalysed cross-coupling. mark for My Articles similar articles
Chemistry World
January 23, 2012
James Urquhart
Simple One Stop Shop for Difluoromethylation A new process developed by researchers opens the way for adding difluoromethyl (CF 2H) groups to drugs and agrochemicals in order to enhance their properties. mark for My Articles similar articles
Chemistry World
May 29, 2015
Derek Lowe
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. mark for My Articles similar articles
Chemistry World
March 2012
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug mark for My Articles similar articles
Chemistry World
February 27, 2012
Phillip Broadwith
Bending carbonyl reactivity rules Belgian chemists have uncovered a method to bypass the standard reactivity hierarchy of carbonyl compounds, allowing a ketone or ester to be reduced in the presence of a more reactive aldehyde. mark for My Articles similar articles
Chemistry World
November 27, 2008
Lewis Brindley
Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially. mark for My Articles similar articles
Chemistry World
December 2009
Paul Docherty
Column: Totally Synthetic What turns a good synthesis into a great synthesis are the steps surrounding that motif, something that Darren Dixon from the University of Oxford, UK, exemplifies with this synthesis of Nakadomarin A. mark for My Articles similar articles
Chemistry World
November 26, 2013
Paul Docherty
Gone to completion Where is the art of total synthesis headed? mark for My Articles similar articles
Chemistry World
September 2008
Derek Lowe
Column: In the pipeline The author remembers leaving the ivory towers of academe to trade 'unusual and beautiful' for 'useful' mark for My Articles similar articles
Chemistry World
September 23, 2013
Karl Collins
The portable chemist's consultant The portable chemist's consultant from Phil Baran's laboratory at the Scripps Research Institute in California challenges the concept of a 'textbook' by providing a progressive, multimedia textbook application. This is the future of scientific textbooks. mark for My Articles similar articles
Chemistry World
January 2009
Paul Docherty
Column: Totally Synthetic In the search for new biologically active natural products, sometimes a team isolating a new compound family will be lucky enough to find one active member. mark for My Articles similar articles
Chemistry World
October 29, 2014
Lycopodium alkaloids Not all natural products are created equal. A glance at the total synthesis literature from the past decade is enough to discover that some molecules attract a lot more attention than others. mark for My Articles similar articles
Chemistry World
October 1, 2012
Paul Docherty
Prostaglandin F2I There's been no shortage of grant funding for synthetic chemistry of the prostaglandins, keeping some of the finest minds in organic chemistry engaged over the last five decades. mark for My Articles similar articles
Chemistry World
April 2007
Derek Lowe
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort? mark for My Articles similar articles
Chemistry World
February 2007
Dylan Stiles
Bench Monkey There's a recurring problem in synthesis where functional groups in a molecule are prone to unwanted side reactions. mark for My Articles similar articles
Chemistry World
October 2009
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions mark for My Articles similar articles
Chemistry World
October 31, 2012
Paul Docherty
Epicoccin G The class of natural products known as 2,5-diketopiperazines is both broad and synthetically well-trodden. An important sub-class of these targets are found with a sprinkling of sulfur atoms, and seem particularly well-suited to pathogen-bashing. mark for My Articles similar articles
Chemistry World
May 29, 2013
Paul Docherty
Pactamycin A member of a 'rival' field stating that a molecule is 'inaccessible by synthetic organic chemistry' is like a red rag to the proverbial bull. This challenge surrounds analogs of pactamycin, a complex cyclopentane-based target with an exceptionally potent biological profile. mark for My Articles similar articles
Chemistry World
December 3, 2009
Simon Hadlington
C-H Bond Activation Takes the Relaxing Route Chemists have uncovered a key factor that helps determine the reactivity of a C-H bond to oxidation. mark for My Articles similar articles
Reactive Reports
September 2007
David Bradley
Insecticidal Synthesis The efforts of 40 PhD chemistry students and many others have found a way to construct azadirachtin -- a natural insecticide from the neem tree -- in a total synthesis of 64 individual chemical reaction steps. mark for My Articles similar articles
Chemistry World
July 2008
Kevin Rogers
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril mark for My Articles similar articles
Chemistry World
June 19, 2013
John Hayward
Science of synthesis workbench edition: water in organic synthesis If a chemist is looking to do chemistry in (or on) water at the bench, Water in organic synthesis by Shu Kobayashi will be their guide. mark for My Articles similar articles
Chemistry World
July 10, 2013
Karl Collins
An 'Aye' for details Today, using methods developed by masters of their trade, the modern greats of total synthesis demonstrate that almost any molecule can be prepared given time and effort. mark for My Articles similar articles
Chemistry World
July 14, 2011
Simon Hadlington
Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor. mark for My Articles similar articles
Chemistry World
July 27, 2015
(--)-Jiadifenolide I believe that Ryan Shenvi's could well be the last synthesis we see of the popular neurotrophic agent jiadifenolide, at least for some time. mark for My Articles similar articles
Chemistry World
May 22, 2015
Jason Woolford
Organic chemistry's complexity conundrum Process chemists in the US have developed a tool to generate a unique index they have termed a molecule's 'current complexity', which also accounts for changes over time due to the impact of new technologies. mark for My Articles similar articles
Chemistry World
June 11, 2008
James Mitchell Crow
New Hope for Anticancer Agent The mode of action of a rare natural product with promising cytotoxic activity has been revealed by scientists in the US while a UK group have come up with a particularly efficient chemical synthesis. mark for My Articles similar articles
Chemistry World
September 2, 2013
Paul Docherty
Steviol A discussion is presented on new ways to synthesize the diterpenoid steviol. mark for My Articles similar articles
Chemistry World
November 28, 2013
Put the chemistry back in medicinal chemistry Today, synthetic skill is valued and appreciated much less in medicinal chemistry than in chemical development, though it is equally important for both. Much of the blame lies with the mismeasurement of productivity. mark for My Articles similar articles
Chemistry World
October 12, 2011
Joanne Thomson
Hot Chemistry Temperature played a crucial role in David MacMillan's decision to study chemistry. mark for My Articles similar articles
Chemistry World
January 22, 2014
Eleanor Merritt
Designer esters for complex carbohydrates Scientists based in the US have developed a new strategy to simplify the chemical synthesis of complex carbohydrates. mark for My Articles similar articles
Chemistry World
July 2009
Paul Docherty
Column: Totally Synthetic When it comes to making large natural products, different researchers will often propose identical 'end-game' strategies to complete the target. mark for My Articles similar articles
Chemistry World
March 22, 2012
Ross McLaren
Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule. mark for My Articles similar articles
Chemistry World
February 2011
Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential mark for My Articles similar articles
Chemistry World
September 6, 2006
Michael Gross
Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses. mark for My Articles similar articles
Chemistry World
July 1, 2012
Paul Docherty
Vincorine Cage-structured natural products are some of the most appealing (if perhaps not appetising) targets for organic chemists -- perhaps due to their obvious intricacy of form, but also because of their structural rigidity. mark for My Articles similar articles
Chemistry World
June 2010
Paul Docherty
Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups. mark for My Articles similar articles
Chemistry World
January 21, 2013
Michael Parkin
Flow synthesis for anticancer drug UK chemists have used a combination of flow chemistry methods with solid-supported scavengers and reagents to synthesize the active pharmaceutical ingredient, imatinib, of the anticancer drug Gleevec. mark for My Articles similar articles
Chemistry World
April 2011
Paul Docherty
Column: Totally Synthetic Reactions in the synthesis of guanacastepene N. Discovered in fungi growing on trees in the Guanacaste conservation area in Costa Rica, several syntheses of this family have appeared in the decade since their isolation. mark for My Articles similar articles
Chemistry World
August 2008
Paul Docherty
Column: Totally Synthetic Impersonating nature isn't easy, and biomimetic syntheses are remarkable in two senses. mark for My Articles similar articles
Chemistry World
August 30, 2009
Phillip Broadwith
C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules. mark for My Articles similar articles
Chemistry World
November 2006
Dylan Stiles
Opinion: Bench Monkey Synthesis is an academically sanctioned opportunity to live on the edge. Handling dangerous materials can be thrilling, like skydiving in a lab coat. mark for My Articles similar articles