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Chemistry World
April 11, 2014
The sultan of synthesis Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers mark for My Articles similar articles
Chemistry World
October 13, 2006
Richard Van Noorden
Fastest Synthesis in the West A promising antibiotic with a novel mechanism of action has been synthesized for the first time -- and with impressive speed. mark for My Articles similar articles
Chemistry World
January 15, 2015
Katrina Kramer
Chemistry's toughest total synthesis challenge put on hold by lack of funds How many chemists does it take to synthesize a molecule? The answer is 20, at least when it comes to maitotoxin, quite possibly the toughest total synthesis challenge around. mark for My Articles similar articles
Chemistry World
April 2007
Derek Lowe
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort? mark for My Articles similar articles
Chemistry World
August 1, 2013
James Urquhart
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions. mark for My Articles similar articles
Chemistry World
August 10, 2007
Richard Van Noorden
Azadirachtin Sees First Total Synthesis A complex natural product has finally succumbed to its first total synthesis after 22 years of attempts by eminent organic chemists. mark for My Articles similar articles
Chemistry World
November 28, 2013
Put the chemistry back in medicinal chemistry Today, synthetic skill is valued and appreciated much less in medicinal chemistry than in chemical development, though it is equally important for both. Much of the blame lies with the mismeasurement of productivity. mark for My Articles similar articles
Chemistry World
November 2007
Dylan Stiles
Column: Bench Monkey Total synthesis is not immune to the vagaries of fickle fashion. mark for My Articles similar articles
Chemistry World
November 27, 2008
Lewis Brindley
Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially. mark for My Articles similar articles
Chemistry World
August 2007
Derek Lowe
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. mark for My Articles similar articles
Chemistry World
October 29, 2014
Lycopodium alkaloids Not all natural products are created equal. A glance at the total synthesis literature from the past decade is enough to discover that some molecules attract a lot more attention than others. mark for My Articles similar articles
Chemistry World
July 10, 2013
Karl Collins
An 'Aye' for details Today, using methods developed by masters of their trade, the modern greats of total synthesis demonstrate that almost any molecule can be prepared given time and effort. mark for My Articles similar articles
Chemistry World
August 22, 2012
Philip Ball
The automatic chemist Bartosz Grzybowski of Northwestern University -- who has already established himself as one of our most inventive chemists -- has unveiled a 'chemo-informatic' scheme, Chematica, that can stake a reasonable claim to being paradigm-changing. mark for My Articles similar articles
Chemistry World
February 6, 2014
Simon Lewis
Design and strategy in organic synthesis In this comprehensive treatise by Hanessian and others, a wide range of total syntheses from many different laboratories is used to exemplify different approaches to synthetic design. mark for My Articles similar articles
Chemistry World
July 14, 2011
Simon Hadlington
Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor. mark for My Articles similar articles
Chemistry World
March 21, 2007
Alison Stoddart
Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products. mark for My Articles similar articles
Chemistry World
January 2009
Paul Docherty
Column: Totally Synthetic In the search for new biologically active natural products, sometimes a team isolating a new compound family will be lucky enough to find one active member. mark for My Articles similar articles
Chemistry World
April 2011
Paul Docherty
Column: Totally Synthetic Reactions in the synthesis of guanacastepene N. Discovered in fungi growing on trees in the Guanacaste conservation area in Costa Rica, several syntheses of this family have appeared in the decade since their isolation. mark for My Articles similar articles
Chemistry World
August 2008
Paul Docherty
Column: Totally Synthetic Impersonating nature isn't easy, and biomimetic syntheses are remarkable in two senses. mark for My Articles similar articles
Chemistry World
October 28, 2013
Edward Anderson
More dead ends and detours en route to successful total synthesis In this book Miguel A Sierra and his co-authors revisit their 2004 coverage of 'tales of the unexpected' in complex molecule total synthesis. mark for My Articles similar articles
Chemistry World
July 27, 2012
Samantha Cheung
A sweeter approach to sugar synthesis Sugar chemists have developed a highly efficient synthetic pathway to produce a variety of oligosaccharides from scratch. mark for My Articles similar articles
Chemistry World
May 29, 2013
Paul Docherty
Pactamycin A member of a 'rival' field stating that a molecule is 'inaccessible by synthetic organic chemistry' is like a red rag to the proverbial bull. This challenge surrounds analogs of pactamycin, a complex cyclopentane-based target with an exceptionally potent biological profile. mark for My Articles similar articles
Information Today
December 16, 2010
CAS Introduces SciFinder Enhancements The enhancements will accelerate researchers' workflow and are especially valuable for synthetic chemists and other researchers who are engaged in lab preparations and synthesis planning. mark for My Articles similar articles
Chemistry World
November 16, 2012
Yuandi Li
(+)-Myrrhanol C made Spanish chemists have completed the stereospecific total synthesis of (+)-myrrhanol C. This compound is a natural triterpene isolated from mastic gum, a substance well known for its medicinal properties as well as use in various cuisines. mark for My Articles similar articles
Chemistry World
October 2009
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions mark for My Articles similar articles
Chemistry World
June 29, 2015
Organic odysseys Valuable compounds often come from the strangest places, and in such small concentrations that synthetic chemistry has to step up. mark for My Articles similar articles
Chemistry World
March 2012
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug mark for My Articles similar articles
Chemistry World
July 30, 2014
Psylloborine A It's a somewhat surprising assertion that almost a fifth of natural products are thought to include a dimerization step somewhere in their biosynthesis. mark for My Articles similar articles
Chemistry World
April 2011
Column: In the Pipeline If you look over the whole pharmacopeia, you'll see there are a lot of compounds that got their start as natural products. mark for My Articles similar articles
Chemistry World
February 2010
Paul Docherty
Column: Totally Synthetic Palau'amine is an alkaloid which has stubbornly held off synthesis for over 15 years. Its nemesis comes in the form of Phil Baran at the Scripps Research Institute, La Jolla, US. mark for My Articles similar articles
Reactive Reports
September 2007
David Bradley
Insecticidal Synthesis The efforts of 40 PhD chemistry students and many others have found a way to construct azadirachtin -- a natural insecticide from the neem tree -- in a total synthesis of 64 individual chemical reaction steps. mark for My Articles similar articles
Chemistry World
March 2009
Paul Docherty
Column: Totally Synthetic Marine waters have produced some of the biggest celebrities of the natural product world - including the brevitoxins, saxitoxins and tetrodotoxins, 1 famous as much for the sheer human effort needed for their landmark syntheses as for their complexity and size. mark for My Articles similar articles
Chemistry World
August 11, 2015
Emma Cooper
Streamlined synthesis yields longer sugar chains By using bigger building blocks, scientists in the UK have shown they can make much longer oligosaccharide sequences than previously possible. mark for My Articles similar articles
Chemistry World
June 19, 2013
John Hayward
Science of synthesis workbench edition: water in organic synthesis If a chemist is looking to do chemistry in (or on) water at the bench, Water in organic synthesis by Shu Kobayashi will be their guide. mark for My Articles similar articles
Chemistry World
February 28, 2013
Paul Docherty
Lyconadin A Since its isolation from the clubmoss Lycopodium complanatum in 2001, lyconadina A has been party to three total syntheses. All that interest stems from anti-Alzheimer's activity attributed to the lycopodium family. mark for My Articles similar articles
Chemistry World
July 2008
Kevin Rogers
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril mark for My Articles similar articles
Chemistry World
June 11, 2008
James Mitchell Crow
New Hope for Anticancer Agent The mode of action of a rare natural product with promising cytotoxic activity has been revealed by scientists in the US while a UK group have come up with a particularly efficient chemical synthesis. mark for My Articles similar articles
Chemistry World
May 2012
Paul Docherty
Column: Totally Synthetic Hopeanol and hopeahainol A mark for My Articles similar articles
Chemistry World
February 2, 2012
Philip Robinson
Ultrafast NMR shows the way Chemists have created an ultrafast NMR technique that can 'watch' how chemical reactions occur in real time. They've used the technique to follow the formation of pyrimidines from carbonyls and even identified new intermediates never before thought to be part of the reaction. mark for My Articles similar articles
Chemistry World
May 20, 2015
Katrina Kramer
Taking the lead on drug discovery Researchers from the UK have developed a straightforward strategy for making compounds that have the potential to become clinical drugs. mark for My Articles similar articles
Chemistry World
May 29, 2015
Derek Lowe
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. mark for My Articles similar articles
Chemistry World
May 1, 2014
Ned Stafford
Synthetic biology vision for Europe unveiled A new 'strategic vision' for synthetic biology has laid out the steps Europe needs to take in the next five to 10 year to nurture the field, with chemistry a key part of its strategy. mark for My Articles similar articles
Chemistry World
January 2011
Paul Docherty
Column: Totally Synthetic Although the story is incomplete, the target is a worthy challenge - leiodolides A and B have powerful activity and selectivity against NI60 tumour cells, and may lead to therapeutic agents. mark for My Articles similar articles
Chemistry World
January 2008
Philip Ball
Column: The Crucible Does chemical space limit a chemists' creativity? mark for My Articles similar articles
Chemistry World
August 2010
Paul Docherty
Column: Totally Synthetic The total synthesis of macrolide targets is now a relatively mature field. Any synthesis that bucks these trends grabs attention, with a recent publication of dictyosphaeric acid A by Richard Taylor's team at the University of York, UK, a case in point. mark for My Articles similar articles
Chemistry World
May 2009
Paul Docherty
Column: Totally Synthetic After a glorious 1980s and 90s as the pin-ups of total synthesis, it seems that the macrolides are now passe, and all the cool kids have moved on to work on alkaloid natural products mark for My Articles similar articles
Chemistry World
May 2010
Paul Docherty
Column: Totally Synthetic In the case of englerin A, the synthetic strategies used by Dawei Ma's group at the Chinese Academy of Sciences, Shanghai, China, 1 and Antonio Echavarren's team at Rovira and Virgili University, Tarragona, Spain, 2 are extremely similar. mark for My Articles similar articles
Chemistry World
October 2008
Paul Docherty
Column: Totally Synthetic Samuel Danishefsky of Columbia University (and the Sloan-Kettering Institute for cancer research), has focused on function rather than family. His many synthetic conquests are unified by their cancer-busting potential. mark for My Articles similar articles
Chemistry World
January 22, 2014
Eleanor Merritt
Designer esters for complex carbohydrates Scientists based in the US have developed a new strategy to simplify the chemical synthesis of complex carbohydrates. mark for My Articles similar articles
Chemistry World
January 2, 2013
Paul Docherty
Flueggine A One of the most prolific sources of biologically active natural products is traditional medicines -- whose active components can be exceptionally potent. The Euphorbiaceae family of plants is a productive source of medicinal targets, including the Securinega alkaloids. mark for My Articles similar articles