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Chemistry World April 11, 2014 |
The sultan of synthesis Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers  |
Chemistry World October 13, 2006 Richard Van Noorden |
Fastest Synthesis in the West A promising antibiotic with a novel mechanism of action has been synthesized for the first time -- and with impressive speed.  |
Chemistry World January 15, 2015 Katrina Kramer |
Chemistry's toughest total synthesis challenge put on hold by lack of funds How many chemists does it take to synthesize a molecule? The answer is 20, at least when it comes to maitotoxin, quite possibly the toughest total synthesis challenge around.  |
Chemistry World April 2007 Derek Lowe |
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort?  |
Chemistry World August 1, 2013 James Urquhart |
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions.  |
Chemistry World August 10, 2007 Richard Van Noorden |
Azadirachtin Sees First Total Synthesis A complex natural product has finally succumbed to its first total synthesis after 22 years of attempts by eminent organic chemists.  |
Chemistry World November 28, 2013 |
Put the chemistry back in medicinal chemistry Today, synthetic skill is valued and appreciated much less in medicinal chemistry than in chemical development, though it is equally important for both. Much of the blame lies with the mismeasurement of productivity.  |
Chemistry World November 2007 Dylan Stiles |
Column: Bench Monkey Total synthesis is not immune to the vagaries of fickle fashion.  |
Chemistry World November 27, 2008 Lewis Brindley |
Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially.  |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve.  |
Chemistry World October 29, 2014 |
Lycopodium alkaloids Not all natural products are created equal. A glance at the total synthesis literature from the past decade is enough to discover that some molecules attract a lot more attention than others.  |
Chemistry World July 10, 2013 Karl Collins |
An 'Aye' for details Today, using methods developed by masters of their trade, the modern greats of total synthesis demonstrate that almost any molecule can be prepared given time and effort.  |
Chemistry World August 22, 2012 Philip Ball |
The automatic chemist Bartosz Grzybowski of Northwestern University -- who has already established himself as one of our most inventive chemists -- has unveiled a 'chemo-informatic' scheme, Chematica, that can stake a reasonable claim to being paradigm-changing.  |
Chemistry World February 6, 2014 Simon Lewis |
Design and strategy in organic synthesis In this comprehensive treatise by Hanessian and others, a wide range of total syntheses from many different laboratories is used to exemplify different approaches to synthetic design.  |
Chemistry World July 14, 2011 Simon Hadlington |
Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor.  |
Chemistry World March 21, 2007 Alison Stoddart |
Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products.  |
Chemistry World January 2009 Paul Docherty |
Column: Totally Synthetic In the search for new biologically active natural products, sometimes a team isolating a new compound family will be lucky enough to find one active member.  |
Chemistry World April 2011 Paul Docherty |
Column: Totally Synthetic Reactions in the synthesis of guanacastepene N. Discovered in fungi growing on trees in the Guanacaste conservation area in Costa Rica, several syntheses of this family have appeared in the decade since their isolation.  |
Chemistry World August 2008 Paul Docherty |
Column: Totally Synthetic Impersonating nature isn't easy, and biomimetic syntheses are remarkable in two senses.  |
Chemistry World October 28, 2013 Edward Anderson |
More dead ends and detours en route to successful total synthesis In this book Miguel A Sierra and his co-authors revisit their 2004 coverage of 'tales of the unexpected' in complex molecule total synthesis.  |
Chemistry World July 27, 2012 Samantha Cheung |
A sweeter approach to sugar synthesis Sugar chemists have developed a highly efficient synthetic pathway to produce a variety of oligosaccharides from scratch.  |
Chemistry World May 29, 2013 Paul Docherty |
Pactamycin A member of a 'rival' field stating that a molecule is 'inaccessible by synthetic organic chemistry' is like a red rag to the proverbial bull. This challenge surrounds analogs of pactamycin, a complex cyclopentane-based target with an exceptionally potent biological profile.  |
Information Today December 16, 2010 |
CAS Introduces SciFinder Enhancements The enhancements will accelerate researchers' workflow and are especially valuable for synthetic chemists and other researchers who are engaged in lab preparations and synthesis planning.  |
Chemistry World November 16, 2012 Yuandi Li |
(+)-Myrrhanol C made Spanish chemists have completed the stereospecific total synthesis of (+)-myrrhanol C. This compound is a natural triterpene isolated from mastic gum, a substance well known for its medicinal properties as well as use in various cuisines.  |
Chemistry World October 2009 |
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions  |
Chemistry World June 29, 2015 |
Organic odysseys Valuable compounds often come from the strangest places, and in such small concentrations that synthetic chemistry has to step up.  |
Chemistry World March 2012 |
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug  |
Chemistry World July 30, 2014 |
Psylloborine A It's a somewhat surprising assertion that almost a fifth of natural products are thought to include a dimerization step somewhere in their biosynthesis.  |
Chemistry World April 2011 |
Column: In the Pipeline If you look over the whole pharmacopeia, you'll see there are a lot of compounds that got their start as natural products.  |
Chemistry World February 2010 Paul Docherty |
Column: Totally Synthetic Palau'amine is an alkaloid which has stubbornly held off synthesis for over 15 years. Its nemesis comes in the form of Phil Baran at the Scripps Research Institute, La Jolla, US.  |
Reactive Reports September 2007 David Bradley |
Insecticidal Synthesis The efforts of 40 PhD chemistry students and many others have found a way to construct azadirachtin -- a natural insecticide from the neem tree -- in a total synthesis of 64 individual chemical reaction steps.  |
Chemistry World March 2009 Paul Docherty |
Column: Totally Synthetic Marine waters have produced some of the biggest celebrities of the natural product world - including the brevitoxins, saxitoxins and tetrodotoxins, 1 famous as much for the sheer human effort needed for their landmark syntheses as for their complexity and size.  |
Chemistry World August 11, 2015 Emma Cooper |
Streamlined synthesis yields longer sugar chains By using bigger building blocks, scientists in the UK have shown they can make much longer oligosaccharide sequences than previously possible.  |
Chemistry World June 19, 2013 John Hayward |
Science of synthesis workbench edition: water in organic synthesis If a chemist is looking to do chemistry in (or on) water at the bench, Water in organic synthesis by Shu Kobayashi will be their guide.  |
Chemistry World February 28, 2013 Paul Docherty |
Lyconadin A Since its isolation from the clubmoss Lycopodium complanatum in 2001, lyconadina A has been party to three total syntheses. All that interest stems from anti-Alzheimer's activity attributed to the lycopodium family.  |
Chemistry World July 2008 Kevin Rogers |
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril  |
Chemistry World June 11, 2008 James Mitchell Crow |
New Hope for Anticancer Agent The mode of action of a rare natural product with promising cytotoxic activity has been revealed by scientists in the US while a UK group have come up with a particularly efficient chemical synthesis.  |
Chemistry World May 2012 Paul Docherty |
Column: Totally Synthetic Hopeanol and hopeahainol A  |
Chemistry World February 2, 2012 Philip Robinson |
Ultrafast NMR shows the way Chemists have created an ultrafast NMR technique that can 'watch' how chemical reactions occur in real time. They've used the technique to follow the formation of pyrimidines from carbonyls and even identified new intermediates never before thought to be part of the reaction.  |
Chemistry World May 20, 2015 Katrina Kramer |
Taking the lead on drug discovery Researchers from the UK have developed a straightforward strategy for making compounds that have the potential to become clinical drugs.  |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.  |
Chemistry World May 1, 2014 Ned Stafford |
Synthetic biology vision for Europe unveiled A new 'strategic vision' for synthetic biology has laid out the steps Europe needs to take in the next five to 10 year to nurture the field, with chemistry a key part of its strategy.  |
Chemistry World January 2011 Paul Docherty |
Column: Totally Synthetic Although the story is incomplete, the target is a worthy challenge - leiodolides A and B have powerful activity and selectivity against NI60 tumour cells, and may lead to therapeutic agents.  |
Chemistry World January 2008 Philip Ball |
Column: The Crucible Does chemical space limit a chemists' creativity?  |
Chemistry World August 2010 Paul Docherty |
Column: Totally Synthetic The total synthesis of macrolide targets is now a relatively mature field. Any synthesis that bucks these trends grabs attention, with a recent publication of dictyosphaeric acid A by Richard Taylor's team at the University of York, UK, a case in point.  |
Chemistry World May 2009 Paul Docherty |
Column: Totally Synthetic After a glorious 1980s and 90s as the pin-ups of total synthesis, it seems that the macrolides are now passe, and all the cool kids have moved on to work on alkaloid natural products  |
Chemistry World May 2010 Paul Docherty |
Column: Totally Synthetic In the case of englerin A, the synthetic strategies used by Dawei Ma's group at the Chinese Academy of Sciences, Shanghai, China, 1 and Antonio Echavarren's team at Rovira and Virgili University, Tarragona, Spain, 2 are extremely similar.  |
Chemistry World October 2008 Paul Docherty |
Column: Totally Synthetic Samuel Danishefsky of Columbia University (and the Sloan-Kettering Institute for cancer research), has focused on function rather than family. His many synthetic conquests are unified by their cancer-busting potential.  |
Chemistry World January 22, 2014 Eleanor Merritt |
Designer esters for complex carbohydrates Scientists based in the US have developed a new strategy to simplify the chemical synthesis of complex carbohydrates.  |
Chemistry World January 2, 2013 Paul Docherty |
Flueggine A One of the most prolific sources of biologically active natural products is traditional medicines -- whose active components can be exceptionally potent. The Euphorbiaceae family of plants is a productive source of medicinal targets, including the Securinega alkaloids.  |