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Chemistry World January 14, 2015 Derek Lowe |
Ignorance is no defense Chemists can be a danger to themselves and others if they don't know enough about the compounds they're working with.  |
Chemistry World March 27, 2014 Derek Lowe |
Known unknowns Most dangerous substances announce themselves by their structures and reactivity, and a competent organic chemist should be able to read those signs.  |
Chemistry World June 1, 2012 Derek Lowe |
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that.  |
Chemistry World March 10, 2006 |
Dual Organometallics Enhance Zinc Reactivity Chemists have synthesised organometallic compounds that enable zinc to participate in directed metalation of organic substrates.  |
Chemistry World January 2011 |
Column: In the pipeline Some medicinal chemists can't get enough fluorines in their molecules. The love-hate relationship is explained.  |
Chemistry World October 2011 Derek Lowe |
Column: In the Pipeline Research chemistry has hazards, some of them potentially fatal, and attention to safety is an essential part of working in the field. The hard part comes when you try to figure out what sort of 'attention to safety' is most helpful.  |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.  |
Chemistry World April 10, 2008 Mark Peplow |
'Pot-in-a-Pot' Technique Makes Impossible Cascade Reactions Easy A simple technique that nests a series of reaction vessels could help chemists avoid the tedium and expense of purifying organic compounds after each step of a long synthesis.  |
Chemistry World November 27, 2013 Derek Lowe |
Rolling boulders uphill A lot of preclinical projects don't even get off the ground, and many that do still never deliver anything to the development groups.  |
Chemistry World June 2008 |
Column: In the pipeline The author, a medicinal chemist working on preclinical drug discovery, takes a look at the differences between chemists and biologists working on the same team.  |
Chemistry World March 20, 2007 Tom Westgate |
Is Your Lab Ready to go Veggie? In a recently published review article, Geoffrey Cordell demonstrates that the greengrocer's could be an unexpected goldmine of sustainable, cheap reagents that would benefit chemistry in developing countries.  |
Chemistry World August 2009 Derek Lowe |
Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder  |
Chemistry World June 2008 Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success  |
Chemistry World April 12, 2012 Simon Hadlington |
Recruiting electrophiles for organic cross-coupling Chemists in the US have taken an unconventional approach to carbon cross-coupling and in doing so have potentially opened the door to the rapid and efficient synthesis of a wide range of organic compounds.  |
Chemistry World October 2008 Derek Lowe |
Column: In the pipeline The author seeks a cure for 'compound bloat'  |
Chemistry World August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now?  |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve.  |
Chemistry World July 30, 2015 Derek Lowe |
A precision instrument? How much do medicinal chemists and their biology colleagues really trust each other's data? In the end, they have to, because drug discovery is a team sport.  |
Chemistry World September 4, 2012 Derek Lowe |
Light in the Lab We organic chemists do terrible things to our molecules. How about dissolving the starting materials up in a flask, shining a light into the mixture and coming back later to find it transformed into your product? That's photochemistry.  |
Chemistry World July 2008 Kevin Rogers |
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril  |
Chemistry World September 25, 2015 Derek Lowe |
Spice up your compounds You and your team are optimizing a lead compound, as medicinal chemists are wont to do -- varying its structure to improve its potency, selectivity and other properties.  |
HHMI Bulletin Nov 2011 Sarah C. P. Williams |
Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems.  |
Chemistry World October 29, 2009 Phillip Broadwith |
Two metals are better than one UK chemists have developed reagents that can metallate ethers and ethene at room temperature without them disintegrating.  |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions.  |
Chemistry World October 14, 2008 Simon Hadlington |
Enzymes hit with double punch US chemists have made a small molecule that simultaneously blocks two key enzymes involved in the growth of cancer cells.  |
Chemistry World August 28, 2015 Derek Lowe |
A risky business How much of a risk is it to work in an organic chemistry lab? Back when I was first beginning bench work in graduate school, I was home during the holidays and telling some lab stories.  |
Chemistry World November 12, 2010 Akshat Rathi |
How green is your detergent? Fragranced household products, even those labelled as 'green', can emit large numbers of hazardous chemicals that aren't listed on their labels, US researchers have confirmed.  |
Chemistry World July 27, 2009 Simon Hadlington |
Peer review by live blogging Blogging can immediately bring together expert opinion on a given topic. Poorly reviewed papers claiming novelty can be expected to be rapidly dissected in the blogosphere, as some chemists have found out.  |
Chemistry World November 2007 Derek Lowe |
Column: In the Pipeline Chemists are finally going with the flow.  |
Chemistry World September 7, 2014 Michael Gross |
Bringing chemical synthesis to the masses The promise of a novel approach to building chemical libraries, which only requires simple building blocks in water, without any additional reagents or sample preparation, is inspired by nature.  |
Chemistry World November 2009 Derek Lowe |
Column: In the pipeline The author advises opening your mind during the screening cascade taken by potential drug targets, and remaining goal orientated at all times  |
Chemistry World June 2011 |
Column: In the pipeline Chemists are human. Humans are hierarchical. Therefore...well, therefore, you'll find a number of different roles and levels for scientists in a drug company's labs. Here's a rough ordering, from least experienced to most.  |
Chemistry World July 2, 2013 Derek Lowe |
Lab's laborers lost? There are excellent scientists who are hopeless at administration, just as there are plenty of capable administrators who should never be allowed near flammable solvents.  |
Chemistry World March 22, 2012 Ross McLaren |
Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule.  |
Chemistry World July 26, 2012 Derek Lowe |
Screen shots You might not think that the makeup of a compound screening collection could set off many arguments, but there are a few issues there that will do the trick almost every time.  |
Chemistry World August 2011 |
Column: In the pipeline Derek Lowe highlights the less visible pitfalls on the road to a new drug  |
Chemistry World November 28, 2014 |
Synthesizing the midnight oil Staying up late is nothing new to chemists, especially in a university setting. I enjoyed late nights in the laboratory in graduate school.  |
Chemistry World October 2009 |
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions  |
Chemistry World February 2011 |
Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential  |
Chemistry World December 17, 2012 Patrick Walter |
RSC acquires rights to Merck Index The Royal Society of Chemistry has acquired the rights to the 'bible' of chemistry, the Merck Index, familiar around the world to medicinal chemists and drug discovery scientists.  |
Reactive Reports November 2007 David Bradley |
Organic Uranium The first ever uranium methylidyne molecule has been synthesized by US chemists despite the reactivity of the heavy, heavy metal.  |
Chemistry World September 2008 Derek Lowe |
Column: In the pipeline The author remembers leaving the ivory towers of academe to trade 'unusual and beautiful' for 'useful'  |
Chemistry World October 22, 2009 Simon Hadlington |
Carbenes catalyse metal-metal bonds in organometallics Chemists in the US have discovered a novel way to transform organometallic compounds so that new metal-metal bonds are created.  |
Chemistry World July 23, 2012 Andrea Sella |
Chattaway's spatula Frederick Chattaway British chemist (1860-1944), was a careful and painstaking explorer of the chemical world. He studied some of the most dangerous compounds known, and was prepared to drop academic security for something more interesting.  |
Chemistry World July 2008 Dylan Stiles |
Column: Bench Monkey Work in a chemistry lab long enough, and I can just about guarantee sooner or later you'll battle an accidental fire.  |
Chemistry World March 2012 |
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug  |
Chemistry World October 2010 |
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery  |
Chemistry World March 2012 |
Column: In the pipeline Drug discovery requires experimentation, says Derek Lowe. But chemists can be reluctant to stray from the elements they know and love  |
Chemistry World July 2009 Derek Lowe |
Column: In the pipeline The author wonders where we'd be without the formulation chemists  |
Chemistry World April 2011 |
Column: In the Pipeline If you look over the whole pharmacopeia, you'll see there are a lot of compounds that got their start as natural products.  |