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Chemistry World
January 14, 2015
Derek Lowe
Ignorance is no defense Chemists can be a danger to themselves and others if they don't know enough about the compounds they're working with. mark for My Articles similar articles
Chemistry World
March 27, 2014
Derek Lowe
Known unknowns Most dangerous substances announce themselves by their structures and reactivity, and a competent organic chemist should be able to read those signs. mark for My Articles similar articles
Chemistry World
June 1, 2012
Derek Lowe
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that. mark for My Articles similar articles
Chemistry World
March 10, 2006
Dual Organometallics Enhance Zinc Reactivity Chemists have synthesised organometallic compounds that enable zinc to participate in directed metalation of organic substrates. mark for My Articles similar articles
Chemistry World
January 2011
Column: In the pipeline Some medicinal chemists can't get enough fluorines in their molecules. The love-hate relationship is explained. mark for My Articles similar articles
Chemistry World
October 2011
Derek Lowe
Column: In the Pipeline Research chemistry has hazards, some of them potentially fatal, and attention to safety is an essential part of working in the field. The hard part comes when you try to figure out what sort of 'attention to safety' is most helpful. mark for My Articles similar articles
Chemistry World
May 29, 2015
Derek Lowe
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. mark for My Articles similar articles
Chemistry World
April 10, 2008
Mark Peplow
'Pot-in-a-Pot' Technique Makes Impossible Cascade Reactions Easy A simple technique that nests a series of reaction vessels could help chemists avoid the tedium and expense of purifying organic compounds after each step of a long synthesis. mark for My Articles similar articles
Chemistry World
November 27, 2013
Derek Lowe
Rolling boulders uphill A lot of preclinical projects don't even get off the ground, and many that do still never deliver anything to the development groups. mark for My Articles similar articles
Chemistry World
June 2008
Column: In the pipeline The author, a medicinal chemist working on preclinical drug discovery, takes a look at the differences between chemists and biologists working on the same team. mark for My Articles similar articles
Chemistry World
March 20, 2007
Tom Westgate
Is Your Lab Ready to go Veggie? In a recently published review article, Geoffrey Cordell demonstrates that the greengrocer's could be an unexpected goldmine of sustainable, cheap reagents that would benefit chemistry in developing countries. mark for My Articles similar articles
Chemistry World
August 2009
Derek Lowe
Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder mark for My Articles similar articles
Chemistry World
June 2008
Sarah Houlton
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success mark for My Articles similar articles
Chemistry World
April 12, 2012
Simon Hadlington
Recruiting electrophiles for organic cross-coupling Chemists in the US have taken an unconventional approach to carbon cross-coupling and in doing so have potentially opened the door to the rapid and efficient synthesis of a wide range of organic compounds. mark for My Articles similar articles
Chemistry World
October 2008
Derek Lowe
Column: In the pipeline The author seeks a cure for 'compound bloat' mark for My Articles similar articles
Chemistry World
August 2008
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? mark for My Articles similar articles
Chemistry World
August 2007
Derek Lowe
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. mark for My Articles similar articles
Chemistry World
July 30, 2015
Derek Lowe
A precision instrument? How much do medicinal chemists and their biology colleagues really trust each other's data? In the end, they have to, because drug discovery is a team sport. mark for My Articles similar articles
Chemistry World
September 4, 2012
Derek Lowe
Light in the Lab We organic chemists do terrible things to our molecules. How about dissolving the starting materials up in a flask, shining a light into the mixture and coming back later to find it transformed into your product? That's photochemistry. mark for My Articles similar articles
Chemistry World
July 2008
Kevin Rogers
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril mark for My Articles similar articles
Chemistry World
September 25, 2015
Derek Lowe
Spice up your compounds You and your team are optimizing a lead compound, as medicinal chemists are wont to do -- varying its structure to improve its potency, selectivity and other properties. mark for My Articles similar articles
HHMI Bulletin
Nov 2011
Sarah C. P. Williams
Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems. mark for My Articles similar articles
Chemistry World
October 29, 2009
Phillip Broadwith
Two metals are better than one UK chemists have developed reagents that can metallate ethers and ethene at room temperature without them disintegrating. mark for My Articles similar articles
Chemistry World
November 25, 2014
James Urquhart
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions. mark for My Articles similar articles
Chemistry World
October 14, 2008
Simon Hadlington
Enzymes hit with double punch US chemists have made a small molecule that simultaneously blocks two key enzymes involved in the growth of cancer cells. mark for My Articles similar articles
Chemistry World
August 28, 2015
Derek Lowe
A risky business How much of a risk is it to work in an organic chemistry lab? Back when I was first beginning bench work in graduate school, I was home during the holidays and telling some lab stories. mark for My Articles similar articles
Chemistry World
November 12, 2010
Akshat Rathi
How green is your detergent? Fragranced household products, even those labelled as 'green', can emit large numbers of hazardous chemicals that aren't listed on their labels, US researchers have confirmed. mark for My Articles similar articles
Chemistry World
July 27, 2009
Simon Hadlington
Peer review by live blogging Blogging can immediately bring together expert opinion on a given topic. Poorly reviewed papers claiming novelty can be expected to be rapidly dissected in the blogosphere, as some chemists have found out. mark for My Articles similar articles
Chemistry World
November 2007
Derek Lowe
Column: In the Pipeline Chemists are finally going with the flow. mark for My Articles similar articles
Chemistry World
September 7, 2014
Michael Gross
Bringing chemical synthesis to the masses The promise of a novel approach to building chemical libraries, which only requires simple building blocks in water, without any additional reagents or sample preparation, is inspired by nature. mark for My Articles similar articles
Chemistry World
November 2009
Derek Lowe
Column: In the pipeline The author advises opening your mind during the screening cascade taken by potential drug targets, and remaining goal orientated at all times mark for My Articles similar articles
Chemistry World
June 2011
Column: In the pipeline Chemists are human. Humans are hierarchical. Therefore...well, therefore, you'll find a number of different roles and levels for scientists in a drug company's labs. Here's a rough ordering, from least experienced to most. mark for My Articles similar articles
Chemistry World
July 2, 2013
Derek Lowe
Lab's laborers lost? There are excellent scientists who are hopeless at administration, just as there are plenty of capable administrators who should never be allowed near flammable solvents. mark for My Articles similar articles
Chemistry World
March 22, 2012
Ross McLaren
Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule. mark for My Articles similar articles
Chemistry World
July 26, 2012
Derek Lowe
Screen shots You might not think that the makeup of a compound screening collection could set off many arguments, but there are a few issues there that will do the trick almost every time. mark for My Articles similar articles
Chemistry World
August 2011
Column: In the pipeline Derek Lowe highlights the less visible pitfalls on the road to a new drug mark for My Articles similar articles
Chemistry World
November 28, 2014
Synthesizing the midnight oil Staying up late is nothing new to chemists, especially in a university setting. I enjoyed late nights in the laboratory in graduate school. mark for My Articles similar articles
Chemistry World
October 2009
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions mark for My Articles similar articles
Chemistry World
February 2011
Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential mark for My Articles similar articles
Chemistry World
December 17, 2012
Patrick Walter
RSC acquires rights to Merck Index The Royal Society of Chemistry has acquired the rights to the 'bible' of chemistry, the Merck Index, familiar around the world to medicinal chemists and drug discovery scientists. mark for My Articles similar articles
Reactive Reports
November 2007
David Bradley
Organic Uranium The first ever uranium methylidyne molecule has been synthesized by US chemists despite the reactivity of the heavy, heavy metal. mark for My Articles similar articles
Chemistry World
September 2008
Derek Lowe
Column: In the pipeline The author remembers leaving the ivory towers of academe to trade 'unusual and beautiful' for 'useful' mark for My Articles similar articles
Chemistry World
October 22, 2009
Simon Hadlington
Carbenes catalyse metal-metal bonds in organometallics Chemists in the US have discovered a novel way to transform organometallic compounds so that new metal-metal bonds are created. mark for My Articles similar articles
Chemistry World
July 23, 2012
Andrea Sella
Chattaway's spatula Frederick Chattaway British chemist (1860-1944), was a careful and painstaking explorer of the chemical world. He studied some of the most dangerous compounds known, and was prepared to drop academic security for something more interesting. mark for My Articles similar articles
Chemistry World
July 2008
Dylan Stiles
Column: Bench Monkey Work in a chemistry lab long enough, and I can just about guarantee sooner or later you'll battle an accidental fire. mark for My Articles similar articles
Chemistry World
March 2012
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug mark for My Articles similar articles
Chemistry World
October 2010
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery mark for My Articles similar articles
Chemistry World
March 2012
Column: In the pipeline Drug discovery requires experimentation, says Derek Lowe. But chemists can be reluctant to stray from the elements they know and love mark for My Articles similar articles
Chemistry World
July 2009
Derek Lowe
Column: In the pipeline The author wonders where we'd be without the formulation chemists mark for My Articles similar articles
Chemistry World
April 2011
Column: In the Pipeline If you look over the whole pharmacopeia, you'll see there are a lot of compounds that got their start as natural products. mark for My Articles similar articles