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Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.  |
Chemistry World November 28, 2013 |
Put the chemistry back in medicinal chemistry Today, synthetic skill is valued and appreciated much less in medicinal chemistry than in chemical development, though it is equally important for both. Much of the blame lies with the mismeasurement of productivity.  |
Chemistry World March 25, 2011 Simon Hadlington |
New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists.  |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve.  |
Chemistry World April 2007 Derek Lowe |
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort?  |
Chemistry World August 1, 2013 James Urquhart |
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions.  |
Chemistry World June 11, 2008 James Mitchell Crow |
New Hope for Anticancer Agent The mode of action of a rare natural product with promising cytotoxic activity has been revealed by scientists in the US while a UK group have come up with a particularly efficient chemical synthesis.  |
Chemistry World January 2009 Paul Docherty |
Column: Totally Synthetic In the search for new biologically active natural products, sometimes a team isolating a new compound family will be lucky enough to find one active member.  |
Chemistry World September 20, 2007 Lewis Brindley |
New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction.  |
Chemistry World November 27, 2008 Lewis Brindley |
Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially.  |
Chemistry World July 10, 2013 Karl Collins |
An 'Aye' for details Today, using methods developed by masters of their trade, the modern greats of total synthesis demonstrate that almost any molecule can be prepared given time and effort.  |
Chemistry World May 29, 2013 Paul Docherty |
Pactamycin A member of a 'rival' field stating that a molecule is 'inaccessible by synthetic organic chemistry' is like a red rag to the proverbial bull. This challenge surrounds analogs of pactamycin, a complex cyclopentane-based target with an exceptionally potent biological profile.  |
Chemistry World September 25, 2015 Derek Lowe |
Spice up your compounds You and your team are optimizing a lead compound, as medicinal chemists are wont to do -- varying its structure to improve its potency, selectivity and other properties.  |
Chemistry World March 2012 |
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug  |
Chemistry World November 24, 2011 Elinor Richards |
Blocking cancer's path A concise synthesis of the natural product rasfonin could reignite interest in this molecule as a tool to develop cancer drugs, say scientists from the Netherlands.  |
Chemistry World October 2008 Paul Docherty |
Column: Totally Synthetic Samuel Danishefsky of Columbia University (and the Sloan-Kettering Institute for cancer research), has focused on function rather than family. His many synthetic conquests are unified by their cancer-busting potential.  |
Chemistry World December 2009 Paul Docherty |
Column: Totally Synthetic What turns a good synthesis into a great synthesis are the steps surrounding that motif, something that Darren Dixon from the University of Oxford, UK, exemplifies with this synthesis of Nakadomarin A.  |
Chemistry World November 2008 Paul Docherty |
Column: Totally Synthetic Vannusal B -- This is a classic case of misassigned identity - the structure published by the researchers who first isolated the compound from its natural source has been recreated via total synthesis, and found wanting.  |
Chemistry World June 2010 Paul Docherty |
Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups.  |
Chemistry World August 2011 Paul Docherty |
Column: Totally Synthetic Yuanhuapin, a fabulously complex member of the daphnane diterpene orthoester class of natural products, bears an astonishing twelve contiguous stereogenic centres around its seven rings (look closely!).  |
Chemistry World February 2011 Paul Docherty |
Column: Totally Synthetic Although most of the natural products I've discussed have had biological activity at the core of the rationale for their synthesis, most organic chemists will admit that an unusual chemical structure is by far the stronger draw.  |
Chemistry World November 2, 2015 |
Batzelladine B Of all the diverse substances that nature produces, the alkaloids -- small molecules containing basic nitrogen -- have had the greatest impact on human history and health.  |
Chemistry World July 27, 2015 |
(--)-Jiadifenolide I believe that Ryan Shenvi's could well be the last synthesis we see of the popular neurotrophic agent jiadifenolide, at least for some time.  |
Chemistry World August 30, 2009 Phillip Broadwith |
C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules.  |
Chemistry World October 1, 2012 Paul Docherty |
Prostaglandin F2I There's been no shortage of grant funding for synthetic chemistry of the prostaglandins, keeping some of the finest minds in organic chemistry engaged over the last five decades.  |
Chemistry World March 2011 Paul Docherty |
Column: Totally Synthetic Discovered independently by two chemists in the 1870s, it's remarkable that 140 years later, science is still tweaking and improving the aldol reaction.  |
Chemistry World April 2010 Paul Docherty |
Column: Totally Synthetic When one attempts the first synthesis of a natural product, the set of challenges are often unknown; which intermediates are either inaccessible or unstable, for instance.  |
Chemistry World January 29, 2014 |
Organic matter: Indoxamycins A, C and F In 2012, Erick Carreira's group in Zurich reported the total synthesis of indoxamycin B. 1 This 24-step organometallic tour de force resulted in a structural reassignment and set the bar rather high for future work on this family.  |
Chemistry World February 2011 |
Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential  |
Chemistry World October 28, 2013 Edward Anderson |
More dead ends and detours en route to successful total synthesis In this book Miguel A Sierra and his co-authors revisit their 2004 coverage of 'tales of the unexpected' in complex molecule total synthesis.  |
Chemistry World August 10, 2007 Richard Van Noorden |
Azadirachtin Sees First Total Synthesis A complex natural product has finally succumbed to its first total synthesis after 22 years of attempts by eminent organic chemists.  |
Chemistry World July 27, 2012 Samantha Cheung |
A sweeter approach to sugar synthesis Sugar chemists have developed a highly efficient synthetic pathway to produce a variety of oligosaccharides from scratch.  |
Chemistry World May 20, 2015 Katrina Kramer |
Taking the lead on drug discovery Researchers from the UK have developed a straightforward strategy for making compounds that have the potential to become clinical drugs.  |
Chemistry World May 2010 Paul Docherty |
Column: Totally Synthetic In the case of englerin A, the synthetic strategies used by Dawei Ma's group at the Chinese Academy of Sciences, Shanghai, China, 1 and Antonio Echavarren's team at Rovira and Virgili University, Tarragona, Spain, 2 are extremely similar.  |
Chemistry World July 14, 2011 Simon Hadlington |
Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor.  |
Chemistry World June 25, 2008 Lewis Brindley |
Slick synthesis to sea sponge structure Chemists in the US have devised a new route to (-)-cyanthiwigin F, a complex biomolecule active against tumors  |
Chemistry World January 9, 2014 James Urquhart |
Simple route to add nitrogen to drugs US researchers have discovered a simple one-pot, scaleable way to synthesize aziridines -- three-membered rings that are important building blocks for introducing nitrogen into more complex molecules, including medicinal drugs.  |
Chemistry World June 1, 2012 Derek Lowe |
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that.  |
Chemistry World October 13, 2006 Richard Van Noorden |
Fastest Synthesis in the West A promising antibiotic with a novel mechanism of action has been synthesized for the first time -- and with impressive speed.  |
Chemistry World February 2009 Paul Docherty |
Column: Totally Synthetic The farming squeeze has renewed interest in compounds with anti-insect abilities, especially those known for their activity against specific pests.  |
Chemistry World May 8, 2014 |
Mandelalide A The recent synthesis of the proposed structure of mandelalide A is a good example of a well-designed route that seamlessly integrates some cutting-edge chemistry.  |
Chemistry World May 2012 Paul Docherty |
Column: Totally Synthetic Hopeanol and hopeahainol A  |
Chemistry World June 19, 2013 John Hayward |
Science of synthesis workbench edition: water in organic synthesis If a chemist is looking to do chemistry in (or on) water at the bench, Water in organic synthesis by Shu Kobayashi will be their guide.  |
Chemistry World July 2008 Kevin Rogers |
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril  |
Chemistry World September 6, 2006 Michael Gross |
Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses.  |
Chemistry World November 27, 2013 Derek Lowe |
Rolling boulders uphill A lot of preclinical projects don't even get off the ground, and many that do still never deliver anything to the development groups.  |
Chemistry World October 2010 Paul Docherty |
Barekoxide and barekol Like most scientists, organic chemists can often obsess about a problem, endlessly pursuing the perfect yield or enantioselectivity, often leading to tears and broken glassware.  |
Chemistry World June 2008 |
Column: In the pipeline The author, a medicinal chemist working on preclinical drug discovery, takes a look at the differences between chemists and biologists working on the same team.  |
Chemistry World April 11, 2014 |
The sultan of synthesis Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers  |
Chemistry World June 2011 |
Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan.  |