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Chemistry World
June 11, 2008
James Mitchell Crow
New Hope for Anticancer Agent The mode of action of a rare natural product with promising cytotoxic activity has been revealed by scientists in the US while a UK group have come up with a particularly efficient chemical synthesis. mark for My Articles similar articles
Chemistry World
September 6, 2006
Michael Gross
Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses. mark for My Articles similar articles
Chemistry World
October 13, 2006
Richard Van Noorden
Fastest Synthesis in the West A promising antibiotic with a novel mechanism of action has been synthesized for the first time -- and with impressive speed. mark for My Articles similar articles
Chemistry World
February 10, 2011
James Urquhart
Molecular motor controls chirality A single molecule catalytic system that uses a light driven molecular motor to dynamically control the molecule's chiral states has been developed by scientists in the Netherlands. mark for My Articles similar articles
Chemistry World
February 4, 2011
Elinor Richards
Strychnine in just six steps Strychnine, best known as a poison but also used medicinally as a stimulant, can now be synthesised in just six steps, say US scientists. mark for My Articles similar articles
Chemistry World
March 25, 2011
Simon Hadlington
New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists. mark for My Articles similar articles
Chemistry World
July 27, 2012
Samantha Cheung
A sweeter approach to sugar synthesis Sugar chemists have developed a highly efficient synthetic pathway to produce a variety of oligosaccharides from scratch. mark for My Articles similar articles
Chemistry World
November 27, 2008
Lewis Brindley
Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially. mark for My Articles similar articles
Chemistry World
August 1, 2013
James Urquhart
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions. mark for My Articles similar articles
Chemistry World
May 2010
Paul Docherty
Column: Totally Synthetic In the case of englerin A, the synthetic strategies used by Dawei Ma's group at the Chinese Academy of Sciences, Shanghai, China, 1 and Antonio Echavarren's team at Rovira and Virgili University, Tarragona, Spain, 2 are extremely similar. mark for My Articles similar articles
Chemistry World
August 30, 2009
Phillip Broadwith
C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules. mark for My Articles similar articles
Chemistry World
January 29, 2014
Organic matter: Indoxamycins A, C and F In 2012, Erick Carreira's group in Zurich reported the total synthesis of indoxamycin B. 1 This 24-step organometallic tour de force resulted in a structural reassignment and set the bar rather high for future work on this family. mark for My Articles similar articles
Chemistry World
January 3, 2012
Simon Hadlington
One-pot synthesis creates anticancer candidates Researchers in Germany have developed a simple, rapid and high-yielding cascade synthesis of a collection of polycyclic compounds that resemble indole alkaloid natural products and which interfere with cell division. mark for My Articles similar articles
Chemistry World
June 29, 2015
Organic odysseys Valuable compounds often come from the strangest places, and in such small concentrations that synthetic chemistry has to step up. mark for My Articles similar articles
Chemistry World
June 17, 2010
Andrew Turley
Biocatalyst improves diabetes drug production Researchers have developed an enzyme that can produce a difficult to form chiral amine in a best-selling diabetes therapy. mark for My Articles similar articles
Chemistry World
May 8, 2014
Mandelalide A The recent synthesis of the proposed structure of mandelalide A is a good example of a well-designed route that seamlessly integrates some cutting-edge chemistry. mark for My Articles similar articles
Chemistry World
January 2011
Paul Docherty
Column: Totally Synthetic Although the story is incomplete, the target is a worthy challenge - leiodolides A and B have powerful activity and selectivity against NI60 tumour cells, and may lead to therapeutic agents. mark for My Articles similar articles
Chemistry World
August 25, 2011
David Barden
Rapid Route to Huperzine A US chemists have devised an efficient synthesis of a natural product with great potential as a protectant against chemical warfare agents and in the treatment of Alzheimer's disease. mark for My Articles similar articles
Chemistry World
November 16, 2012
Yuandi Li
(+)-Myrrhanol C made Spanish chemists have completed the stereospecific total synthesis of (+)-myrrhanol C. This compound is a natural triterpene isolated from mastic gum, a substance well known for its medicinal properties as well as use in various cuisines. mark for My Articles similar articles
Chemistry World
March 17, 2014
Eleanor Merritt
Four steps to asthma treatment Scientists based in the US have devised a new way to make Montelukast, a drug used in the treatment of asthma and seasonal allergies. mark for My Articles similar articles
HHMI Bulletin
February 2012
Nicole Kresge
Protein Precision in the Brain with CSF Two causes of autism arise from opposite cellular mechanisms. Too much or too little protein production at the synapse between neurons can cause autism and intellectual disability. mark for My Articles similar articles
Chemistry World
February 6, 2014
Simon Lewis
Design and strategy in organic synthesis In this comprehensive treatise by Hanessian and others, a wide range of total syntheses from many different laboratories is used to exemplify different approaches to synthetic design. mark for My Articles similar articles
Chemistry World
June 1, 2006
Michael Gross
New Twists on Catalysis Chemists around the world have discovered several new twists to improve the performance of asymmetric catalysts in hydrogenation reactions. mark for My Articles similar articles
Chemistry World
June 13, 2008
Richard Van Noorden
Asymmetric ketone catalysis gets pharma-scale makeover An asymmetric catalysis reaction limited to laboratory syntheses has received a makeover that could see it used on a large scale by drug-makers. mark for My Articles similar articles
Chemistry World
February 11, 2011
Leanne Marle
Fighting back against antibiotic resistant bacteria Scientists in Japan have revealed how vancomycin dimers are effective against vancomycin-resistant bacteria. mark for My Articles similar articles
Chemistry World
July 27, 2015
(--)-Jiadifenolide I believe that Ryan Shenvi's could well be the last synthesis we see of the popular neurotrophic agent jiadifenolide, at least for some time. mark for My Articles similar articles
Chemistry World
July 2008
Paul Docherty
Column: Totally Synthetic The target is hypocrellin A, which couldn't look much less like last month's callipeltoside A. Even a casual glance reveals one intriguing feature of this target - the fact it exists in equilibrium with an isomer. mark for My Articles similar articles
Chemistry World
August 2008
Paul Docherty
Column: Totally Synthetic Impersonating nature isn't easy, and biomimetic syntheses are remarkable in two senses. mark for My Articles similar articles
Chemistry World
February 2012
Paul Docherty
Column: Totally Synthetic Medium rings are a beguiling feature found in a host of natural products, owing to their behavioral oddities. mark for My Articles similar articles
Chemistry World
October 14, 2009
James Urquhart
New route to amino acids US scientists have found a new way of making a class of non-natural amino acids that are widely used as components of pharmaceuticals and chiral catalysts. mark for My Articles similar articles
Chemistry World
June 25, 2008
Lewis Brindley
Slick synthesis to sea sponge structure Chemists in the US have devised a new route to (-)-cyanthiwigin F, a complex biomolecule active against tumors mark for My Articles similar articles
Chemistry World
October 10, 2012
Phillip Broadwith
Taming erythropoietin through synthesis US researchers have produced a fully synthetic version of erythropoietin, the glycoprotein responsible for regulating blood cell production. mark for My Articles similar articles
Chemistry World
January 22, 2014
Eleanor Merritt
Designer esters for complex carbohydrates Scientists based in the US have developed a new strategy to simplify the chemical synthesis of complex carbohydrates. mark for My Articles similar articles
Chemistry World
July 17, 2007
Emma Baines
Neurotransmitter Levels Linked to Amnesia The widely accepted role of protein synthesis in memory formation has been questioned in light of data released by US researchers. mark for My Articles similar articles
Chemistry World
March 21, 2007
Alison Stoddart
Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products. mark for My Articles similar articles
Chemistry World
July 15, 2013
Eleanor Merritt
A chemical approach to biological antifreeze Scientists in New Zealand and the US have synthesized a protein that helps inhibit ice crystal growth in Antarctic fish. mark for My Articles similar articles
Chemistry World
January 2009
Paul Docherty
Column: Totally Synthetic In the search for new biologically active natural products, sometimes a team isolating a new compound family will be lucky enough to find one active member. mark for My Articles similar articles
Chemistry World
November 17, 2008
Simon Hadlington
Catalyst flexes for extra control US chemists have developed a new type of catalyst capable of exerting high stereochemical control over olefin metathesis reactions mark for My Articles similar articles
Chemistry World
July 2009
Paul Docherty
Column: Totally Synthetic When it comes to making large natural products, different researchers will often propose identical 'end-game' strategies to complete the target. mark for My Articles similar articles
Chemistry World
December 2009
Paul Docherty
Column: Totally Synthetic What turns a good synthesis into a great synthesis are the steps surrounding that motif, something that Darren Dixon from the University of Oxford, UK, exemplifies with this synthesis of Nakadomarin A. mark for My Articles similar articles
Chemistry World
July 14, 2011
Simon Hadlington
Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor. mark for My Articles similar articles
Chemistry World
August 10, 2007
Richard Van Noorden
Azadirachtin Sees First Total Synthesis A complex natural product has finally succumbed to its first total synthesis after 22 years of attempts by eminent organic chemists. mark for My Articles similar articles
Chemistry World
April 11, 2014
The sultan of synthesis Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers mark for My Articles similar articles
Chemistry World
March 2009
Paul Docherty
Column: Totally Synthetic Marine waters have produced some of the biggest celebrities of the natural product world - including the brevitoxins, saxitoxins and tetrodotoxins, 1 famous as much for the sheer human effort needed for their landmark syntheses as for their complexity and size. mark for My Articles similar articles
Chemistry World
April 2007
Derek Lowe
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort? mark for My Articles similar articles
Chemistry World
August 2010
Paul Docherty
Column: Totally Synthetic The total synthesis of macrolide targets is now a relatively mature field. Any synthesis that bucks these trends grabs attention, with a recent publication of dictyosphaeric acid A by Richard Taylor's team at the University of York, UK, a case in point. mark for My Articles similar articles
Chemistry World
October 2010
Paul Docherty
Barekoxide and barekol Like most scientists, organic chemists can often obsess about a problem, endlessly pursuing the perfect yield or enantioselectivity, often leading to tears and broken glassware. mark for My Articles similar articles
Chemistry World
January 2010
Paul Docherty
Column: Totally Synthetic Of all the natural product classes, the steroid family are perhaps the most prevalent in the public consciousness; from cholesterol to testosterone, their infamy inflates the 'science bit' in countless advertisements. mark for My Articles similar articles
Chemistry World
September 4, 2008
Fred Campbell
Two catalysts better than one US researchers have cracked a long standing problem in chemical synthesis - the catalytic alpha-alkylation of aldehydes - by combining two catalysts in one pot. mark for My Articles similar articles
Chemistry World
October 10, 2010
Andy Extance
DNA strides into organic synthesis US scientists have used a DNA walker to synthesise an organic molecule in a series of steps, without intervention, for the first time. mark for My Articles similar articles