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Chemistry World June 11, 2008 James Mitchell Crow |
New Hope for Anticancer Agent The mode of action of a rare natural product with promising cytotoxic activity has been revealed by scientists in the US while a UK group have come up with a particularly efficient chemical synthesis.  |
Chemistry World September 6, 2006 Michael Gross |
Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses.  |
Chemistry World October 13, 2006 Richard Van Noorden |
Fastest Synthesis in the West A promising antibiotic with a novel mechanism of action has been synthesized for the first time -- and with impressive speed.  |
Chemistry World February 10, 2011 James Urquhart |
Molecular motor controls chirality A single molecule catalytic system that uses a light driven molecular motor to dynamically control the molecule's chiral states has been developed by scientists in the Netherlands.  |
Chemistry World February 4, 2011 Elinor Richards |
Strychnine in just six steps Strychnine, best known as a poison but also used medicinally as a stimulant, can now be synthesised in just six steps, say US scientists.  |
Chemistry World March 25, 2011 Simon Hadlington |
New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists.  |
Chemistry World July 27, 2012 Samantha Cheung |
A sweeter approach to sugar synthesis Sugar chemists have developed a highly efficient synthetic pathway to produce a variety of oligosaccharides from scratch.  |
Chemistry World November 27, 2008 Lewis Brindley |
Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially.  |
Chemistry World August 1, 2013 James Urquhart |
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions.  |
Chemistry World May 2010 Paul Docherty |
Column: Totally Synthetic In the case of englerin A, the synthetic strategies used by Dawei Ma's group at the Chinese Academy of Sciences, Shanghai, China, 1 and Antonio Echavarren's team at Rovira and Virgili University, Tarragona, Spain, 2 are extremely similar.  |
Chemistry World August 30, 2009 Phillip Broadwith |
C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules.  |
Chemistry World January 29, 2014 |
Organic matter: Indoxamycins A, C and F In 2012, Erick Carreira's group in Zurich reported the total synthesis of indoxamycin B. 1 This 24-step organometallic tour de force resulted in a structural reassignment and set the bar rather high for future work on this family.  |
Chemistry World January 3, 2012 Simon Hadlington |
One-pot synthesis creates anticancer candidates Researchers in Germany have developed a simple, rapid and high-yielding cascade synthesis of a collection of polycyclic compounds that resemble indole alkaloid natural products and which interfere with cell division.  |
Chemistry World June 29, 2015 |
Organic odysseys Valuable compounds often come from the strangest places, and in such small concentrations that synthetic chemistry has to step up.  |
Chemistry World June 17, 2010 Andrew Turley |
Biocatalyst improves diabetes drug production Researchers have developed an enzyme that can produce a difficult to form chiral amine in a best-selling diabetes therapy.  |
Chemistry World May 8, 2014 |
Mandelalide A The recent synthesis of the proposed structure of mandelalide A is a good example of a well-designed route that seamlessly integrates some cutting-edge chemistry.  |
Chemistry World January 2011 Paul Docherty |
Column: Totally Synthetic Although the story is incomplete, the target is a worthy challenge - leiodolides A and B have powerful activity and selectivity against NI60 tumour cells, and may lead to therapeutic agents.  |
Chemistry World August 25, 2011 David Barden |
Rapid Route to Huperzine A US chemists have devised an efficient synthesis of a natural product with great potential as a protectant against chemical warfare agents and in the treatment of Alzheimer's disease.  |
Chemistry World November 16, 2012 Yuandi Li |
(+)-Myrrhanol C made Spanish chemists have completed the stereospecific total synthesis of (+)-myrrhanol C. This compound is a natural triterpene isolated from mastic gum, a substance well known for its medicinal properties as well as use in various cuisines.  |
Chemistry World March 17, 2014 Eleanor Merritt |
Four steps to asthma treatment Scientists based in the US have devised a new way to make Montelukast, a drug used in the treatment of asthma and seasonal allergies.  |
HHMI Bulletin February 2012 Nicole Kresge |
Protein Precision in the Brain with CSF Two causes of autism arise from opposite cellular mechanisms. Too much or too little protein production at the synapse between neurons can cause autism and intellectual disability.  |
Chemistry World February 6, 2014 Simon Lewis |
Design and strategy in organic synthesis In this comprehensive treatise by Hanessian and others, a wide range of total syntheses from many different laboratories is used to exemplify different approaches to synthetic design.  |
Chemistry World June 1, 2006 Michael Gross |
New Twists on Catalysis Chemists around the world have discovered several new twists to improve the performance of asymmetric catalysts in hydrogenation reactions.  |
Chemistry World June 13, 2008 Richard Van Noorden |
Asymmetric ketone catalysis gets pharma-scale makeover An asymmetric catalysis reaction limited to laboratory syntheses has received a makeover that could see it used on a large scale by drug-makers.  |
Chemistry World February 11, 2011 Leanne Marle |
Fighting back against antibiotic resistant bacteria Scientists in Japan have revealed how vancomycin dimers are effective against vancomycin-resistant bacteria.  |
Chemistry World July 27, 2015 |
(--)-Jiadifenolide I believe that Ryan Shenvi's could well be the last synthesis we see of the popular neurotrophic agent jiadifenolide, at least for some time.  |
Chemistry World July 2008 Paul Docherty |
Column: Totally Synthetic The target is hypocrellin A, which couldn't look much less like last month's callipeltoside A. Even a casual glance reveals one intriguing feature of this target - the fact it exists in equilibrium with an isomer.  |
Chemistry World August 2008 Paul Docherty |
Column: Totally Synthetic Impersonating nature isn't easy, and biomimetic syntheses are remarkable in two senses.  |
Chemistry World February 2012 Paul Docherty |
Column: Totally Synthetic Medium rings are a beguiling feature found in a host of natural products, owing to their behavioral oddities.  |
Chemistry World October 14, 2009 James Urquhart |
New route to amino acids US scientists have found a new way of making a class of non-natural amino acids that are widely used as components of pharmaceuticals and chiral catalysts.  |
Chemistry World June 25, 2008 Lewis Brindley |
Slick synthesis to sea sponge structure Chemists in the US have devised a new route to (-)-cyanthiwigin F, a complex biomolecule active against tumors  |
Chemistry World October 10, 2012 Phillip Broadwith |
Taming erythropoietin through synthesis US researchers have produced a fully synthetic version of erythropoietin, the glycoprotein responsible for regulating blood cell production.  |
Chemistry World January 22, 2014 Eleanor Merritt |
Designer esters for complex carbohydrates Scientists based in the US have developed a new strategy to simplify the chemical synthesis of complex carbohydrates.  |
Chemistry World July 17, 2007 Emma Baines |
Neurotransmitter Levels Linked to Amnesia The widely accepted role of protein synthesis in memory formation has been questioned in light of data released by US researchers.  |
Chemistry World March 21, 2007 Alison Stoddart |
Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products.  |
Chemistry World July 15, 2013 Eleanor Merritt |
A chemical approach to biological antifreeze Scientists in New Zealand and the US have synthesized a protein that helps inhibit ice crystal growth in Antarctic fish.  |
Chemistry World January 2009 Paul Docherty |
Column: Totally Synthetic In the search for new biologically active natural products, sometimes a team isolating a new compound family will be lucky enough to find one active member.  |
Chemistry World November 17, 2008 Simon Hadlington |
Catalyst flexes for extra control US chemists have developed a new type of catalyst capable of exerting high stereochemical control over olefin metathesis reactions  |
Chemistry World July 2009 Paul Docherty |
Column: Totally Synthetic When it comes to making large natural products, different researchers will often propose identical 'end-game' strategies to complete the target.  |
Chemistry World December 2009 Paul Docherty |
Column: Totally Synthetic What turns a good synthesis into a great synthesis are the steps surrounding that motif, something that Darren Dixon from the University of Oxford, UK, exemplifies with this synthesis of Nakadomarin A.  |
Chemistry World July 14, 2011 Simon Hadlington |
Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor.  |
Chemistry World August 10, 2007 Richard Van Noorden |
Azadirachtin Sees First Total Synthesis A complex natural product has finally succumbed to its first total synthesis after 22 years of attempts by eminent organic chemists.  |
Chemistry World April 11, 2014 |
The sultan of synthesis Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers  |
Chemistry World March 2009 Paul Docherty |
Column: Totally Synthetic Marine waters have produced some of the biggest celebrities of the natural product world - including the brevitoxins, saxitoxins and tetrodotoxins, 1 famous as much for the sheer human effort needed for their landmark syntheses as for their complexity and size.  |
Chemistry World April 2007 Derek Lowe |
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort?  |
Chemistry World August 2010 Paul Docherty |
Column: Totally Synthetic The total synthesis of macrolide targets is now a relatively mature field. Any synthesis that bucks these trends grabs attention, with a recent publication of dictyosphaeric acid A by Richard Taylor's team at the University of York, UK, a case in point.  |
Chemistry World October 2010 Paul Docherty |
Barekoxide and barekol Like most scientists, organic chemists can often obsess about a problem, endlessly pursuing the perfect yield or enantioselectivity, often leading to tears and broken glassware.  |
Chemistry World January 2010 Paul Docherty |
Column: Totally Synthetic Of all the natural product classes, the steroid family are perhaps the most prevalent in the public consciousness; from cholesterol to testosterone, their infamy inflates the 'science bit' in countless advertisements.  |
Chemistry World September 4, 2008 Fred Campbell |
Two catalysts better than one US researchers have cracked a long standing problem in chemical synthesis - the catalytic alpha-alkylation of aldehydes - by combining two catalysts in one pot.  |
Chemistry World October 10, 2010 Andy Extance |
DNA strides into organic synthesis US scientists have used a DNA walker to synthesise an organic molecule in a series of steps, without intervention, for the first time.  |