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Chemistry World
January 23, 2012
James Urquhart
Simple One Stop Shop for Difluoromethylation A new process developed by researchers opens the way for adding difluoromethyl (CF 2H) groups to drugs and agrochemicals in order to enhance their properties. mark for My Articles similar articles
Chemistry World
July 9, 2012
Phillip Broadwith
'Molecular cobra' turns C-H to C=C A reagent developed by US chemists can selectively introduce synthetically useful C=C double bonds into unactivated carbon chains, guided by an activating group attached to a nearby oxygen or nitrogen atom. mark for My Articles similar articles
Chemistry World
September 28, 2015
Karl Collins
A witches' brew for trifluoromethylation Trifluoromethylating phenols is one example of a reaction that would be incredibly useful when attempting to tune the chemical and biological properties of molecules for pharmaceutical and agrochemical research. mark for My Articles similar articles
Chemistry World
August 17, 2009
James Urquhart
New method for fluorinating compounds Fluorine atoms are incorporated into aromatic organic compounds for many reasons, including their ability to increase metabolic stability, solubility and bioavailability. mark for My Articles similar articles
Chemistry World
December 6, 2012
Simon Hadlington
Chemists crack fluoroform challenge US scientists appear to have cracked a long-standing problem in organofluorine chemistry -- how to find a simple and efficient way to use the low-cost and abundant compound fluoroform as a trifluoromethylation agent. mark for My Articles similar articles
Chemistry World
June 24, 2010
Phillip Broadwith
Aryl rings get a fluorine fix A mild and effective method for coupling trifluoromethyl groups on to aryl rings has been developed by US chemists. mark for My Articles similar articles
Chemistry World
April 11, 2014
The sultan of synthesis Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers mark for My Articles similar articles
Chemistry World
February 21, 2007
Tom Westgate
Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules. mark for My Articles similar articles
Chemistry World
May 22, 2015
James Urquhart
Complex amines made easy (and cheap) Phil Baran's lab at the Scripps Research Institute, La Jolla, has come up with a protocol that repurposes two readily available and inexpensive feedstock building blocks; olefins and nitroarenes, via iron-catalysed cross-coupling. mark for My Articles similar articles
Chemistry World
August 24, 2010
Lewis Brindley
A better way to add radioactive fluorine Making compounds that contain the useful radioisotope fluorine-18 ( 18F) could be much easier in future, say researchers in the UK and Finland. mark for My Articles similar articles
Chemistry World
March 21, 2007
Alison Stoddart
Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products. mark for My Articles similar articles
Chemistry World
May 29, 2015
Derek Lowe
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. mark for My Articles similar articles
Chemistry World
August 2008
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? mark for My Articles similar articles
Chemistry World
June 23, 2011
Simon Hadlington
Breaking the carbon-fluorine bond US chemists have discovered a new way to break the bond between carbon and fluorine atoms - the strongest carbon bond there is. mark for My Articles similar articles
Chemistry World
January 2011
Column: In the pipeline Some medicinal chemists can't get enough fluorines in their molecules. The love-hate relationship is explained. mark for My Articles similar articles
Chemistry World
November 1, 2007
Richard Van Noorden
Step Change for Organic Synthesis US chemists discovered how to attack a complex molecule's unreactive carbon-hydrogen bonds, without resorting to wasteful synthetic aids like protecting and directing groups. mark for My Articles similar articles
Chemistry World
November 3, 2008
Simon Hadlington
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? mark for My Articles similar articles
Chemistry World
May 31, 2009
Nina Notman
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used. mark for My Articles similar articles
Chemistry World
June 2008
Sarah Houlton
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success mark for My Articles similar articles
Chemistry World
March 24, 2015
Karl Collins
Back to basics for silylation While silicon is probably most familiar in organic synthesis as part of protecting groups, its utility extends much further. mark for My Articles similar articles
Chemistry World
August 14, 2014
Elisabeth Ratcliffe
Photoredox route to medically-important heterocycles Researchers in the US have developed a new photo catalyzed coupling reaction that could provide a pathway to a huge number of biologically active compounds. mark for My Articles similar articles
Chemistry World
September 13, 2012
Ian Le guillou
Fluorination via porphyrin A manganese porphyrin has been used to selectively fluorinate sp 3 carbon -- hydrogen bonds using silver fluoride as a source of fluorine. mark for My Articles similar articles
Chemistry World
August 1, 2013
James Urquhart
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions. mark for My Articles similar articles
Chemistry World
November 3, 2011
David Bradley
Faster Synthesis of Fluorine Radioisotope Imaging Agents A palladium-containing fluorination reagent can be used to quickly synthesise aromatic molecules labelled with fluorine-18, a positron emitter used in molecular imaging. mark for My Articles similar articles
Chemistry World
December 3, 2009
Simon Hadlington
C-H Bond Activation Takes the Relaxing Route Chemists have uncovered a key factor that helps determine the reactivity of a C-H bond to oxidation. mark for My Articles similar articles
Chemistry World
August 2009
Derek Lowe
Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder mark for My Articles similar articles
Chemistry World
October 2008
Derek Lowe
Column: In the pipeline The author seeks a cure for 'compound bloat' mark for My Articles similar articles
Chemistry World
August 12, 2015
Matthew Gunther
Chemists hold a candle to reagent preservation Scientists in the US now have a solution to end the build-up of chemical waste with a wax capsule that can protect reagents from the atmosphere. mark for My Articles similar articles
Chemistry World
July 26, 2012
Derek Lowe
Screen shots You might not think that the makeup of a compound screening collection could set off many arguments, but there are a few issues there that will do the trick almost every time. mark for My Articles similar articles
Chemistry World
June 1, 2012
Derek Lowe
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that. mark for My Articles similar articles
Chemistry World
July 2008
Kevin Rogers
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril mark for My Articles similar articles
Chemistry World
April 15, 2009
Phillip Broadwith
Heteroaromatic rings of the future UK scientists have created a computer program to work out all the aromatic heterocycles that could be synthesised, hoping to expand the range of molecules used in the pharmaceutical and other industries. mark for My Articles similar articles
Chemistry World
June 14, 2006
Simon Hadlington
Natural Metabolism of Fluorine Scientists have isolated a cluster of bacterial genes responsible for the biochemical processing of fluorine. The research follows the discovery of a unique enzyme that incorporates inorganic fluoride into organic metabolites. mark for My Articles similar articles
Chemistry World
October 2010
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery mark for My Articles similar articles
Chemistry World
April 4, 2013
Phillip Broadwith
A solution to fluoronium riddle The first evidence for hypervalent fluorine cations, or fluoronium ions, in solution has been found by US chemists. mark for My Articles similar articles
Chemistry World
August 2007
Derek Lowe
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. mark for My Articles similar articles
Chemistry World
June 2011
Column: In the pipeline Chemists are human. Humans are hierarchical. Therefore...well, therefore, you'll find a number of different roles and levels for scientists in a drug company's labs. Here's a rough ordering, from least experienced to most. mark for My Articles similar articles
Chemistry World
March 2012
Column: In the pipeline Drug discovery requires experimentation, says Derek Lowe. But chemists can be reluctant to stray from the elements they know and love mark for My Articles similar articles
Chemistry World
February 2008
Dylan Stiles
Column: Bench Monkey Cast a skeptical eye over new ideas in chemistry. mark for My Articles similar articles
Chemistry World
September 2008
Derek Lowe
Column: In the pipeline The author remembers leaving the ivory towers of academe to trade 'unusual and beautiful' for 'useful' mark for My Articles similar articles
Chemistry World
December 2008
Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project. mark for My Articles similar articles
Chemistry World
July 16, 2009
Simon Hadlington
Strange vibrations Researchers in Taiwan have shown that in a relatively simple molecular system the induced vibrations can inhibit the breaking of the bond and slow the reaction down. mark for My Articles similar articles
Chemistry World
September 23, 2013
Karl Collins
The portable chemist's consultant The portable chemist's consultant from Phil Baran's laboratory at the Scripps Research Institute in California challenges the concept of a 'textbook' by providing a progressive, multimedia textbook application. This is the future of scientific textbooks. mark for My Articles similar articles
Chemistry World
July 11, 2012
Neil Withers
Fluorine Finally Found in Nature Traces of elemental fluorine, F 2, have been found in calcium fluoride minerals by German chemists, who suggest that it's produced by uranium also found in the rock. mark for My Articles similar articles
Chemistry World
February 2010
Paul Docherty
Column: Totally Synthetic Palau'amine is an alkaloid which has stubbornly held off synthesis for over 15 years. Its nemesis comes in the form of Phil Baran at the Scripps Research Institute, La Jolla, US. mark for My Articles similar articles
Chemistry World
January 11, 2013
Marie Cote
Following her passion Veronique Gouverneur is professor of chemistry at the University of Oxford, UK. She investigates fluorine chemistry and is working on developing novel synthetic methodologies for the preparation of fluorinated targets. mark for My Articles similar articles