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Chemistry World
April 2010
Paul Docherty
Column: Totally Synthetic When one attempts the first synthesis of a natural product, the set of challenges are often unknown; which intermediates are either inaccessible or unstable, for instance. mark for My Articles similar articles
Chemistry World
June 2009
Paul Docherty
Column: Totally Synthetic With potent bacteria-beating activity, it's no surprise that kendomycin has recently grabbed quite a bit of attention. mark for My Articles similar articles
Chemistry World
December 2011
Paul Docherty
Column: Totally Synthetic An important subclass of marine neurotoxins contains spirocyclic imines. Larger examples such as the pinnatoxins have tended to hog the limelight, but the increasingly prolific Daniel Romo has focused his sights on gymnodimine - a slightly smaller family member. mark for My Articles similar articles
Chemistry World
June 2011
Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan. mark for My Articles similar articles
Chemistry World
June 2010
Paul Docherty
Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups. mark for My Articles similar articles
Chemistry World
March 2011
Paul Docherty
Column: Totally Synthetic Discovered independently by two chemists in the 1870s, it's remarkable that 140 years later, science is still tweaking and improving the aldol reaction. mark for My Articles similar articles
Chemistry World
July 27, 2015
(--)-Jiadifenolide I believe that Ryan Shenvi's could well be the last synthesis we see of the popular neurotrophic agent jiadifenolide, at least for some time. mark for My Articles similar articles
Chemistry World
February 2011
Paul Docherty
Column: Totally Synthetic Although most of the natural products I've discussed have had biological activity at the core of the rationale for their synthesis, most organic chemists will admit that an unusual chemical structure is by far the stronger draw. mark for My Articles similar articles
Chemistry World
January 2012
Paul Docherty
Column: Totally Synthetic What a Japanese team demonstrates in this synthesis of dragmacidin D is the state of the art, uniting all the key fragments using C-H bond couplings. mark for My Articles similar articles
Chemistry World
January 28, 2015
Rubriflordilactone A It's likely that organic chemists have been practicing retrosynthesis in one form or another for at least a century, and certainly for decades before E J Corey formalized the concept in the mid-1990s mark for My Articles similar articles
Chemistry World
July 1, 2012
Paul Docherty
Vincorine Cage-structured natural products are some of the most appealing (if perhaps not appetising) targets for organic chemists -- perhaps due to their obvious intricacy of form, but also because of their structural rigidity. mark for My Articles similar articles
Chemistry World
September 2, 2013
Paul Docherty
Steviol A discussion is presented on new ways to synthesize the diterpenoid steviol. mark for My Articles similar articles
Chemistry World
August 30, 2009
Phillip Broadwith
C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules. mark for My Articles similar articles
Chemistry World
January 29, 2014
Organic matter: Indoxamycins A, C and F In 2012, Erick Carreira's group in Zurich reported the total synthesis of indoxamycin B. 1 This 24-step organometallic tour de force resulted in a structural reassignment and set the bar rather high for future work on this family. mark for My Articles similar articles
Chemistry World
November 2011
Paul Docherty
Column: Totally Synthetic Gelsemoxonine has an extra four-membered azetidine ring, making for a considerable synthetic challenge. mark for My Articles similar articles
Chemistry World
February 4, 2011
Elinor Richards
Strychnine in just six steps Strychnine, best known as a poison but also used medicinally as a stimulant, can now be synthesised in just six steps, say US scientists. mark for My Articles similar articles
Chemistry World
January 24, 2013
Paul Docherty
Hyperforin Studies of St John's wort have found several biologically active ingredients, but the primary agent is hyperforin, a potent inhibitor of several neurotransmitters. mark for My Articles similar articles
Chemistry World
October 2009
Paul Docherty
Column: Totally Synthetic It's been a while since I've seen such a battle for the 'first publication' of a molecule as has recently been witnessed for haplophytine. mark for My Articles similar articles
Chemistry World
February 2010
Paul Docherty
Column: Totally Synthetic Palau'amine is an alkaloid which has stubbornly held off synthesis for over 15 years. Its nemesis comes in the form of Phil Baran at the Scripps Research Institute, La Jolla, US. mark for My Articles similar articles
Chemistry World
October 2010
Paul Docherty
Barekoxide and barekol Like most scientists, organic chemists can often obsess about a problem, endlessly pursuing the perfect yield or enantioselectivity, often leading to tears and broken glassware. mark for My Articles similar articles
Chemistry World
December 20, 2007
Richard Van Noorden
Off-the-Peg Organic Synthesis Goes Commercial Chemists have created an efficient way to make small molecules by repeatedly using just one coupling reaction to clip together pre-prepared chemical fragments is going commercial. mark for My Articles similar articles
Chemistry World
September 2011
Paul Docherty
Column: Totally Synthetic Corey Stephenson of Boston University is an expert a type of reaction called photochemical reduction-oxidation. He has charmed photons into performing many chemical tricks, but one is a photoredox dehalogenation using blue light and a ruthenium bipyridyl catalyst. mark for My Articles similar articles
Chemistry World
July 30, 2013
Paul Docherty
Melotenine A Chirality, where would we be without you? Often the bane of the synthetic chemist's life, the challenge of asymmetry is perhaps what makes total synthesis so endlessly intriguing. mark for My Articles similar articles
Chemistry World
February 28, 2013
Paul Docherty
Lyconadin A Since its isolation from the clubmoss Lycopodium complanatum in 2001, lyconadina A has been party to three total syntheses. All that interest stems from anti-Alzheimer's activity attributed to the lycopodium family. mark for My Articles similar articles
Chemistry World
August 2011
Paul Docherty
Column: Totally Synthetic Yuanhuapin, a fabulously complex member of the daphnane diterpene orthoester class of natural products, bears an astonishing twelve contiguous stereogenic centres around its seven rings (look closely!). mark for My Articles similar articles
Chemistry World
September 2008
Paul Docherty
Column: Totally Synthetic The need to discover new antibiotics to treat resistant strains of bacteria is a well- documented and discussed challenge for chemists. mark for My Articles similar articles
Chemistry World
January 2, 2013
Paul Docherty
Flueggine A One of the most prolific sources of biologically active natural products is traditional medicines -- whose active components can be exceptionally potent. The Euphorbiaceae family of plants is a productive source of medicinal targets, including the Securinega alkaloids. mark for My Articles similar articles
Chemistry World
August 2010
Paul Docherty
Column: Totally Synthetic The total synthesis of macrolide targets is now a relatively mature field. Any synthesis that bucks these trends grabs attention, with a recent publication of dictyosphaeric acid A by Richard Taylor's team at the University of York, UK, a case in point. mark for My Articles similar articles
Chemistry World
May 2010
Paul Docherty
Column: Totally Synthetic In the case of englerin A, the synthetic strategies used by Dawei Ma's group at the Chinese Academy of Sciences, Shanghai, China, 1 and Antonio Echavarren's team at Rovira and Virgili University, Tarragona, Spain, 2 are extremely similar. mark for My Articles similar articles
Chemistry World
January 2010
Paul Docherty
Column: Totally Synthetic Of all the natural product classes, the steroid family are perhaps the most prevalent in the public consciousness; from cholesterol to testosterone, their infamy inflates the 'science bit' in countless advertisements. mark for My Articles similar articles
Chemistry World
July 16, 2009
Simon Hadlington
Strange vibrations Researchers in Taiwan have shown that in a relatively simple molecular system the induced vibrations can inhibit the breaking of the bond and slow the reaction down. mark for My Articles similar articles
Chemistry World
May 8, 2014
Mandelalide A The recent synthesis of the proposed structure of mandelalide A is a good example of a well-designed route that seamlessly integrates some cutting-edge chemistry. mark for My Articles similar articles
Chemistry World
August 2009
Paul Docherty
Column: Totally Synthetic Richmond Sarpong's research group at University of California, Berkeley, US, have taken quite an interest in lyconadin A, publishing an initial, racemic synthesis. mark for My Articles similar articles
Chemistry World
April 14, 2009
Lewis Brindley
Osmium and pyridine ring together Organic chemists in China have found a way to put osmium into a pyridine ring - leading to the synthesis of the first metallapyridinium complex. mark for My Articles similar articles
Chemistry World
April 10, 2008
Mark Peplow
'Pot-in-a-Pot' Technique Makes Impossible Cascade Reactions Easy A simple technique that nests a series of reaction vessels could help chemists avoid the tedium and expense of purifying organic compounds after each step of a long synthesis. mark for My Articles similar articles
Chemistry World
October 1, 2014
Karl Collins
Twisting activity from amides When I think of asymmetric aldol reactions, what immediately springs to mind is using boron to control enolate geometry and chiral auxiliaries to impart facial selectivity in the addition step. mark for My Articles similar articles
Chemistry World
February 2012
Paul Docherty
Column: Totally Synthetic Medium rings are a beguiling feature found in a host of natural products, owing to their behavioral oddities. mark for My Articles similar articles
Chemistry World
February 21, 2008
Lewis Brindley
Esters Made Easy with Indium Indium is the basis of a novel catalyst designed to make useful cyclic esters. This catalyst could greatly simplify the production of chiral dihydropyranones, important structural elements in many natural products and pharmaceuticals. mark for My Articles similar articles
Chemistry World
May 2011
Paul Docherty
Column: Totally Synthetic The ability to understand molecular structure is perhaps both our greatest skill and largest encumbrance as scientists. A quick glance at the structure of a target such as nanolobatolide tells us much about its connectivity and the manner in which it might react. mark for My Articles similar articles
Chemistry World
May 29, 2013
Paul Docherty
Pactamycin A member of a 'rival' field stating that a molecule is 'inaccessible by synthetic organic chemistry' is like a red rag to the proverbial bull. This challenge surrounds analogs of pactamycin, a complex cyclopentane-based target with an exceptionally potent biological profile. mark for My Articles similar articles
Chemistry World
July 2009
Paul Docherty
Column: Totally Synthetic When it comes to making large natural products, different researchers will often propose identical 'end-game' strategies to complete the target. mark for My Articles similar articles
Chemistry World
October 29, 2014
Lycopodium alkaloids Not all natural products are created equal. A glance at the total synthesis literature from the past decade is enough to discover that some molecules attract a lot more attention than others. mark for My Articles similar articles
Chemistry World
September 2009
Paul Docherty
Column: Totally Synthetic Maduropeptin chromophore (the active component of a chromopore-protein complex, noted as for its potent antitumor and antibiotic activity) is built of two distinct domains mark for My Articles similar articles
Chemistry World
December 2009
Paul Docherty
Column: Totally Synthetic What turns a good synthesis into a great synthesis are the steps surrounding that motif, something that Darren Dixon from the University of Oxford, UK, exemplifies with this synthesis of Nakadomarin A. mark for My Articles similar articles
Chemistry World
November 2008
Paul Docherty
Column: Totally Synthetic Vannusal B -- This is a classic case of misassigned identity - the structure published by the researchers who first isolated the compound from its natural source has been recreated via total synthesis, and found wanting. mark for My Articles similar articles
Chemistry World
November 27, 2012
Paul Docherty
Pentalenolactone A methyl ester One team that really gets the Pauson -- Khand reaction or the PKR and all its nuances is that led by Zhen Yang at Peking University in Beijing, China. They recently published a very neat synthesis of the intricate pentalenolactone mark for My Articles similar articles
Chemistry World
October 2008
Paul Docherty
Column: Totally Synthetic Samuel Danishefsky of Columbia University (and the Sloan-Kettering Institute for cancer research), has focused on function rather than family. His many synthetic conquests are unified by their cancer-busting potential. mark for My Articles similar articles
Chemistry World
January 2011
Paul Docherty
Column: Totally Synthetic Although the story is incomplete, the target is a worthy challenge - leiodolides A and B have powerful activity and selectivity against NI60 tumour cells, and may lead to therapeutic agents. mark for My Articles similar articles
Chemistry World
August 25, 2011
David Barden
Rapid Route to Huperzine A US chemists have devised an efficient synthesis of a natural product with great potential as a protectant against chemical warfare agents and in the treatment of Alzheimer's disease. mark for My Articles similar articles
Chemistry World
December 2010
Paul Docherty
Column: Totally Synthetic In a conversation at the beginning of this year, a friend and I considered the most challenging targets available to the total-synthesizer - and maoecrystal V was at the top of the list. mark for My Articles similar articles