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Chemistry World
October 2011
Paul Docherty
Column: Totally Synthetic Antioxidants are not only found in human cells, but also in bacterial cell walls - and a good example is synechoxanthin. mark for My Articles similar articles
Chemistry World
June 2011
Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan. mark for My Articles similar articles
Chemistry World
October 2008
Paul Docherty
Column: Totally Synthetic Samuel Danishefsky of Columbia University (and the Sloan-Kettering Institute for cancer research), has focused on function rather than family. His many synthetic conquests are unified by their cancer-busting potential. mark for My Articles similar articles
Chemistry World
August 30, 2009
Phillip Broadwith
C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules. mark for My Articles similar articles
Chemistry World
June 2010
Paul Docherty
Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups. mark for My Articles similar articles
Chemistry World
December 20, 2007
Richard Van Noorden
Off-the-Peg Organic Synthesis Goes Commercial Chemists have created an efficient way to make small molecules by repeatedly using just one coupling reaction to clip together pre-prepared chemical fragments is going commercial. mark for My Articles similar articles
Chemistry World
June 2009
Paul Docherty
Column: Totally Synthetic With potent bacteria-beating activity, it's no surprise that kendomycin has recently grabbed quite a bit of attention. mark for My Articles similar articles
Chemistry World
June 1, 2012
Paul Docherty
atrop-Abyssomicin C This member of the abyssomicin family is the only one to achieve bacteria-bashing prowess, and is also the only one to feature atropisomerism -- a relatively unusual form of stereoisomerism in naturally occurring species mark for My Articles similar articles
Chemistry World
September 2009
Paul Docherty
Column: Totally Synthetic Maduropeptin chromophore (the active component of a chromopore-protein complex, noted as for its potent antitumor and antibiotic activity) is built of two distinct domains mark for My Articles similar articles
Chemistry World
April 2010
Paul Docherty
Column: Totally Synthetic When one attempts the first synthesis of a natural product, the set of challenges are often unknown; which intermediates are either inaccessible or unstable, for instance. mark for My Articles similar articles
Chemistry World
March 2011
Paul Docherty
Column: Totally Synthetic Discovered independently by two chemists in the 1870s, it's remarkable that 140 years later, science is still tweaking and improving the aldol reaction. mark for My Articles similar articles
Chemistry World
February 28, 2013
Paul Docherty
Lyconadin A Since its isolation from the clubmoss Lycopodium complanatum in 2001, lyconadina A has been party to three total syntheses. All that interest stems from anti-Alzheimer's activity attributed to the lycopodium family. mark for My Articles similar articles
Chemistry World
September 2010
Paul Docherty
Column: Totally Synthetic After a target has been synthesised, and the question of 'can we make this?' has been answered, perhaps the most important remaining question is 'how did nature make it?' mark for My Articles similar articles
Chemistry World
January 29, 2014
Organic matter: Indoxamycins A, C and F In 2012, Erick Carreira's group in Zurich reported the total synthesis of indoxamycin B. 1 This 24-step organometallic tour de force resulted in a structural reassignment and set the bar rather high for future work on this family. mark for My Articles similar articles
Chemistry World
May 2010
Paul Docherty
Column: Totally Synthetic In the case of englerin A, the synthetic strategies used by Dawei Ma's group at the Chinese Academy of Sciences, Shanghai, China, 1 and Antonio Echavarren's team at Rovira and Virgili University, Tarragona, Spain, 2 are extremely similar. mark for My Articles similar articles
Chemistry World
August 16, 2009
Tom Bond
Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis. mark for My Articles similar articles
Chemistry World
February 2010
Paul Docherty
Column: Totally Synthetic Palau'amine is an alkaloid which has stubbornly held off synthesis for over 15 years. Its nemesis comes in the form of Phil Baran at the Scripps Research Institute, La Jolla, US. mark for My Articles similar articles
Chemistry World
December 2009
Paul Docherty
Column: Totally Synthetic What turns a good synthesis into a great synthesis are the steps surrounding that motif, something that Darren Dixon from the University of Oxford, UK, exemplifies with this synthesis of Nakadomarin A. mark for My Articles similar articles
Chemistry World
February 2011
Paul Docherty
Column: Totally Synthetic Although most of the natural products I've discussed have had biological activity at the core of the rationale for their synthesis, most organic chemists will admit that an unusual chemical structure is by far the stronger draw. mark for My Articles similar articles
Chemistry World
November 2010
Carbon Couplers Take the Prize Three giants of organic chemistry, who pioneered palladium-catalysed cross coupling reactions, have shared this year's Nobel prize. mark for My Articles similar articles
Chemistry World
May 8, 2014
Mandelalide A The recent synthesis of the proposed structure of mandelalide A is a good example of a well-designed route that seamlessly integrates some cutting-edge chemistry. mark for My Articles similar articles
Chemistry World
July 2010
Paul Docherty
Column: Totally Synthetic Isolated in 1986, the steroid family of aplykurodinones have shown selective cytotoxicity in a variety of cancer cell lines, and add to the phenomenal list of steroids with potent medicinal properties. mark for My Articles similar articles
Chemistry World
May 29, 2013
Paul Docherty
Pactamycin A member of a 'rival' field stating that a molecule is 'inaccessible by synthetic organic chemistry' is like a red rag to the proverbial bull. This challenge surrounds analogs of pactamycin, a complex cyclopentane-based target with an exceptionally potent biological profile. mark for My Articles similar articles
Chemistry World
July 2008
Paul Docherty
Column: Totally Synthetic The target is hypocrellin A, which couldn't look much less like last month's callipeltoside A. Even a casual glance reveals one intriguing feature of this target - the fact it exists in equilibrium with an isomer. mark for My Articles similar articles
Chemistry World
December 2010
Paul Docherty
Column: Totally Synthetic In a conversation at the beginning of this year, a friend and I considered the most challenging targets available to the total-synthesizer - and maoecrystal V was at the top of the list. mark for My Articles similar articles
Chemistry World
November 27, 2012
Paul Docherty
Pentalenolactone A methyl ester One team that really gets the Pauson -- Khand reaction or the PKR and all its nuances is that led by Zhen Yang at Peking University in Beijing, China. They recently published a very neat synthesis of the intricate pentalenolactone mark for My Articles similar articles
Chemistry World
July 1, 2012
Paul Docherty
Vincorine Cage-structured natural products are some of the most appealing (if perhaps not appetising) targets for organic chemists -- perhaps due to their obvious intricacy of form, but also because of their structural rigidity. mark for My Articles similar articles
Chemistry World
October 31, 2012
Paul Docherty
Epicoccin G The class of natural products known as 2,5-diketopiperazines is both broad and synthetically well-trodden. An important sub-class of these targets are found with a sprinkling of sulfur atoms, and seem particularly well-suited to pathogen-bashing. mark for My Articles similar articles
Chemistry World
January 2010
Paul Docherty
Column: Totally Synthetic Of all the natural product classes, the steroid family are perhaps the most prevalent in the public consciousness; from cholesterol to testosterone, their infamy inflates the 'science bit' in countless advertisements. mark for My Articles similar articles
Chemistry World
May 24, 2007
James Mitchell Crow
Palladium Coupling in Fewer Steps Look out Suzuki - Canadian chemists have successfully joined up simple benzene ring-like aromatics without any pre-activation. mark for My Articles similar articles
Chemistry World
June 2008
Paul Docherty
Column: Totally Synthetic Harvard University's David Evans is renowned for his prowess with an aldol reaction, and he has used the endlessly flexible transformation to make a diverse range of natural products. mark for My Articles similar articles
Chemistry World
December 2008
Paul Docherty
Column: Totally Synthetic Pseudolaric acid B: regular readers of this column's online incarnation will have noticed that this is the second appearance for this particular synthesis. mark for My Articles similar articles
Chemistry World
November 3, 2008
Simon Hadlington
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? mark for My Articles similar articles
Chemistry World
April 2009
Paul Docherty
Column: Totally Synthetic Perhaps the most frustrating part of being a synthetic chemist is the jealousy with which we must regard nature mark for My Articles similar articles
Chemistry World
July 2009
Paul Docherty
Column: Totally Synthetic When it comes to making large natural products, different researchers will often propose identical 'end-game' strategies to complete the target. mark for My Articles similar articles
Chemistry World
January 2009
Paul Docherty
Column: Totally Synthetic In the search for new biologically active natural products, sometimes a team isolating a new compound family will be lucky enough to find one active member. mark for My Articles similar articles
Chemistry World
March 8, 2006
Simon Hadlington
New Route to C-Glycoside Creation Overcomes Earlier Drawbacks A one-pot process for creating C-glycosides could help prepare robust analogues of naturally occurring carbohydrates. The technique could ultimately be used to make carbohydrate derivatives more widely available for use in applications from drugs to biosensors. mark for My Articles similar articles
Chemistry World
November 2010
Paul Docherty
Column: Totally Synthetic Perhaps the most familiar (and dull - they do say that familiarity breeds contempt.) chemical reaction to medicinal chemists is the amide bond formation. mark for My Articles similar articles
Chemistry World
March 2012
Paul Docherty
Column: Totally Synthetic Ring strain is a fascinating phenomenon - one that is best understood with plastic modelling kits, wearing safety specs for ring sizes of four or less. mark for My Articles similar articles
Chemistry World
January 2012
Paul Docherty
Column: Totally Synthetic What a Japanese team demonstrates in this synthesis of dragmacidin D is the state of the art, uniting all the key fragments using C-H bond couplings. mark for My Articles similar articles
Chemistry World
November 5, 2013
Paul Docherty
Marcfortines B & C Natural product isolation is generally a tale of a journey to an obscure or inaccessible location, followed by pulping a harmless plant or marine sponge to get at compounds made by some bacteria hiding out in the core. mark for My Articles similar articles
Chemistry World
October 2009
Paul Docherty
Column: Totally Synthetic It's been a while since I've seen such a battle for the 'first publication' of a molecule as has recently been witnessed for haplophytine. mark for My Articles similar articles
Chemistry World
November 2, 2015
Batzelladine B Of all the diverse substances that nature produces, the alkaloids -- small molecules containing basic nitrogen -- have had the greatest impact on human history and health. mark for My Articles similar articles
Chemistry World
November 2009
Paul Docherty
Column: Totally Synthetic The hunt for anticancer therapies is inextricably linked with natural products (such as taxol), and more specifically with macrolides. mark for My Articles similar articles
Chemistry World
January 2, 2013
Paul Docherty
Flueggine A One of the most prolific sources of biologically active natural products is traditional medicines -- whose active components can be exceptionally potent. The Euphorbiaceae family of plants is a productive source of medicinal targets, including the Securinega alkaloids. mark for My Articles similar articles
Chemistry World
November 27, 2008
Lewis Brindley
Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially. mark for My Articles similar articles
Chemistry World
October 2010
Paul Docherty
Barekoxide and barekol Like most scientists, organic chemists can often obsess about a problem, endlessly pursuing the perfect yield or enantioselectivity, often leading to tears and broken glassware. mark for My Articles similar articles
Chemistry World
May 2011
Paul Docherty
Column: Totally Synthetic The ability to understand molecular structure is perhaps both our greatest skill and largest encumbrance as scientists. A quick glance at the structure of a target such as nanolobatolide tells us much about its connectivity and the manner in which it might react. mark for My Articles similar articles
Chemistry World
February 21, 2008
Lewis Brindley
Esters Made Easy with Indium Indium is the basis of a novel catalyst designed to make useful cyclic esters. This catalyst could greatly simplify the production of chiral dihydropyranones, important structural elements in many natural products and pharmaceuticals. mark for My Articles similar articles
Chemistry World
August 2008
Paul Docherty
Column: Totally Synthetic Impersonating nature isn't easy, and biomimetic syntheses are remarkable in two senses. mark for My Articles similar articles