| Similar Articles |
 |
Chemistry World October 2010 |
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery  |
Reactive Reports Issue 58 |
ID Tags for Teenage Molecules One academic team has developed a logical technology that allows them to generate millions of unique tags to track sub-microscopic objects.  |
Chemistry World August 23, 2010 Lewis Brindley |
Microscopic barcodes with extra stirring A way to label molecules with colourful barcodes has been developed by chemists in South Korea.  |
Chemistry World May 31, 2009 Nina Notman |
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used.  |
Chemistry World November 2008 Derek Lowe |
Column: In the pipeline Drug discovery chemists live by assay data; we depend on these numbers to tell us if we're heading in the right direction with our molecules.  |
Chemistry World November 2009 Derek Lowe |
Column: In the pipeline The author advises opening your mind during the screening cascade taken by potential drug targets, and remaining goal orientated at all times  |
Chemistry World April 2, 2009 Ned Stafford |
Fluorescent probes take screening to next level Researchers have developed a new high-throughput screening technique that could shed light on the biochemical activities of numerous proteins about which little is currently known.  |
Bio-IT World December 15, 2003 Malorye A. Branca |
Scenes from a Cell Breakthroughs are making cell-based screening faster, easier, more powerful.  |
Chemistry World September 12, 2008 Rebecca Trager |
NIH funds chemical biology network NIH-funded scientists will have access to the tools for rapidly screening hundreds of thousands of small molecules against many novel biological assays at lower costs than previously possible,' said the agency's director, Elias Zerhouni.  |
Bio-IT World October 14, 2004 Robert M. Frederickson |
Nanosphere Strikes Gold Recently, scientists at Nanosphere developed a colorimetric method for DNA detection that obviates the need for target or signal amplification.  |
Bio-IT World September 2005 John Russell |
BioSeek's MAP to Discovery Now, after roughly five years of platform development and building a database of assays, BioSeek seems poised for growth.  |
The Motley Fool May 25, 2007 Brian Orelli |
Amylin Sifts for Gold The biotech mines extra value from its compound library. Investors, take note.  |
Bio-IT World April 16, 2004 Kevin Davies |
The Matrix Revolutions Serenex, a company dedicated to drug discovery, uses a proprietary matrix, or affinity media, to bind purine-binding protiens - a process that could transform the drug discovery business.  |
Chemistry World November 6, 2009 Phillip Broadwith |
Enzyme binds both sides of the mirror European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before.  |
Chemistry World July 26, 2012 Derek Lowe |
Screen shots You might not think that the makeup of a compound screening collection could set off many arguments, but there are a few issues there that will do the trick almost every time.  |
Reactive Reports Issue 41 David Bradley |
Chip Chops Time off Drug Discovery Process A next-generation optical screening platform can screen a vast number of compounds rapidly by passing wave after wave of compounds in solution over the surface of the biochip.  |
Chemistry World October 2008 Derek Lowe |
Column: In the pipeline The author seeks a cure for 'compound bloat'  |
Bio-IT World January 21, 2005 Robert M. Frederickson |
High-Throughput Science Although genomic assays led the charge toward high-throughput science, new detection systems and formats are enabling the application of high-throughput techniques to proteins and cells.  |
Chemistry World June 1, 2012 Derek Lowe |
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that.  |
Bio-IT World May 19, 2004 Julia Boguslavsky |
Is Microfluidics Equipped for HTS? As microfluidics technologies mature and increase in throughput, they are starting to offer a highly accurate, flexible, and economical alternative to conventional high-throughput screening (HTS) platforms.  |
Chemistry World March 23, 2009 Hayley Birch |
Speeding up screening for chiral catalysts U.S. researchers say their method represents a 'standard workhorse' for discovery and optimisation of chiral catalysts, such as those widely used by the pharmaceutical and pesticide industries.  |
Technology Research News March 23, 2005 |
Nanowires track molecular activity Researchers from Harvard University have found a way to use transistors made from silicon nanowires to gain information about how small molecules bind to proteins.  |
The Motley Fool September 24, 2007 Billy Fisher |
A Fountain of Youth? A study sponsored by Sirtris Pharmaceutical shows potential for the fight against aging. Investors, take note.  |
Bio-IT World July 2005 Johan Bostrom |
Affymetrix to Acquire ParAllele The companies have been working together for the past two years, with Affymetrix using ParAllele's assay technology with the Affymetrix GeneChip technology. Affymetrix expects to strengthen its assay R&D capabilities and add knowledge in specific assay capabilities through the acquisition.  |
Chemistry World September 29, 2015 |
Navigating chemical space How big is chemistry? I don't mean how important is it, or how many people do it, but rather, how many molecules are there that we could make?  |
Bio-IT World July 2005 David M. Evans |
Cellular Imaging Takes Drug Discovery to New Heights The potential applications and ultimate value of high-content screening (HCS) and cellular image analysis are limited only by the imagination and expertise of the drug discovery groups using them to probe gene function and cell behavior.  |
Chemistry World October 25, 2010 |
Dual Purpose Dyes Offer New Imaging Options US researchers have developed a new series of combined fluorescent and chemiluminescent dye compounds that can be stored at low temperatures and then activated to release near infrared light when warmed to body temperature.  |
Pharmaceutical Executive May 1, 2001 |
On Tour with Merck's Robots Merck's HTS robots move assay plates through the screening process.  |
Chemistry World April 2009 Derek Lowe |
Column: In the pipeline The author considers the problems of addressing drug development out of sequence  |
Chemistry World September 2, 2009 Phillip Broadwith |
Shining a light on DNA-binding drugs in living cells German researchers have used standard circular dichroism spectroscopy to probe interactions between drug molecules and DNA within living cells.  |
Pharmaceutical Executive July 1, 2005 Zaborowski, Hammer & Lawler |
Informatics Rules How global computer systems helped far-flung research centers at Roche work together  |
Reactive Reports December 2006 David Bradley |
Biomolecules Out on a Wing Photonic crystals give butterflies their beautiful colors and synthetic versions are now being developed for a range of technological applications.  |
Bio-IT World December 15, 2004 Kevin Davies |
First Trilogy Machine Installed at Mount Sinai A landmark installation for U.S. Genomics' Single Molecule Analyzer.  |
Chemistry World May 26, 2011 Russell Johnson |
Hunting elusive green fluorescent proteins After a 40 year hunt, scientists have tracked down the genes responsible for fluorescent proteins in Obelia medusa - a type of jellyfish. Knowledge of these genes could lead to new fluorescent protein tags for use in cell biology.  |
Bio-IT World March 2006 Robert M. Frederickson |
Integration, Robotics, and Automation The integration of instruments and technology is a key concept driving the development of advanced life-sciences laboratory automation. More sophisticated robotics are also increasingly being integrated into automated systems.  |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?  |
Bio-IT World April 15, 2003 Robert M. Frederickson |
Protein Chemistry Surfaces Protein chips seek to do for protein expression profiling what DNA chips did for RNA expression.  |
| Industrial Physicist |
Biomimetic Nanotechnology Although biomimetic nanotechnology is in its infancy, with no applications yet reaching commercialization, the barriers in some cases lie mainly in scaling up production processes to industrial levels.  |
The Motley Fool October 16, 2007 Brian Orelli |
Pozen Hedges Its Bets As promised, Pozen and partner GlaxoSmithKline announce that the pair have submitted a response to their approvable letter for Trexima, and that they plan to do an additional just-in-case safety trial.  |
Chemistry World May 1, 2008 Simon Hadlington |
Click chemistry illuminates embryo development US researchers have smuggled modified sugar molecules into a developing zebrafish embryo and then used 'click chemistry' to snap a fluorescent tag onto them to watch cells and tissues forming.  |
D-Lib Jan/Feb 2010 Rose Holley |
Tagging Full Text Searchable Articles: An Overview of Social Tagging Activity in Historic Australian Newspapers August 2008 - August 2009 This article gives an overview of the public reaction to and utilization of the tagging facility in a full-text searchable collection, and provides statistics over a year's duration, observations on the use of tagging and suggestions for future developments.  |
Chemistry World October 20, 2009 James Urquhart |
Gold nanoparticles give super sensitive cancer test The recurrence of prostate cancer could soon be spotted years earlier thanks to a new highly sensitive test developed by US and Austrian researchers.  |
Bio-IT World September 16, 2004 Michael A. Greeley |
Platforms for Pathways Investor interest in the next great blockbuster drug has been blistering hot; Phase II and Phase III compound companies are being funded at a near record-breaking pace now that the IPO window seems to be slightly open  |
The Motley Fool April 23, 2008 Brian Lawler |
Glaxo's Three-Quarter-Billion-Dollar Gamble Glaxo adds another development stage drugmaker to its portfolio. Investors take note.  |
Chemistry World March 5, 2013 Amy Middleton-Gear |
Blink and you'll miss it Scientists in Germany have developed a new method for tracking single fluorescent molecules, using linear programming solvers.  |
Chemistry World April 14, 2011 Sarah Farley |
Fish in chips: growing embryos in microfluidic systems Scientists in the Netherlands and the UK have shown for the first time that an animal embryo can develop in a microfluidic environment.  |
D-Lib January 2006 Guy & Tonkin |
Folksonomies: Tidying up Tags? Possibly the real problem with folksonomies in not their chaotic tags but that they are trying to serve two masters at once; the personal collection, and the collective collection.  |
Chemistry World June 14, 2012 Nina Notman |
A celebration of chemistry Simon Cotton's latest book, Every Molecule Tells a Story, is -- in his own words -- 'a celebration of molecules and of chemistry' aimed at school and university students, and their teachers.  |
Reactive Reports May 2007 David Bradley |
Meeting of Molecular Movie Stars New footage confirms Linus Pauling's theory of chemical bonding proposed half a century ago, and could help explain molecular recognition processes important throughout supramolecular chemistry and molecular biology.  |
Chemistry World March 9, 2006 Katharine Sanderson |
Covalent Bonds Crack Under the Strain Chemists must consider engineering principles when designing molecules following news that tough carbon-to-carbon bonds break easily under mechanical strain.  |