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Chemistry World
October 2010
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery mark for My Articles similar articles
Reactive Reports
Issue 58
ID Tags for Teenage Molecules One academic team has developed a logical technology that allows them to generate millions of unique tags to track sub-microscopic objects. mark for My Articles similar articles
Chemistry World
August 23, 2010
Lewis Brindley
Microscopic barcodes with extra stirring A way to label molecules with colourful barcodes has been developed by chemists in South Korea. mark for My Articles similar articles
Chemistry World
May 31, 2009
Nina Notman
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used. mark for My Articles similar articles
Chemistry World
November 2008
Derek Lowe
Column: In the pipeline Drug discovery chemists live by assay data; we depend on these numbers to tell us if we're heading in the right direction with our molecules. mark for My Articles similar articles
Chemistry World
November 2009
Derek Lowe
Column: In the pipeline The author advises opening your mind during the screening cascade taken by potential drug targets, and remaining goal orientated at all times mark for My Articles similar articles
Chemistry World
April 2, 2009
Ned Stafford
Fluorescent probes take screening to next level Researchers have developed a new high-throughput screening technique that could shed light on the biochemical activities of numerous proteins about which little is currently known. mark for My Articles similar articles
Bio-IT World
December 15, 2003
Malorye A. Branca
Scenes from a Cell Breakthroughs are making cell-based screening faster, easier, more powerful. mark for My Articles similar articles
Chemistry World
September 12, 2008
Rebecca Trager
NIH funds chemical biology network NIH-funded scientists will have access to the tools for rapidly screening hundreds of thousands of small molecules against many novel biological assays at lower costs than previously possible,' said the agency's director, Elias Zerhouni. mark for My Articles similar articles
Bio-IT World
October 14, 2004
Robert M. Frederickson
Nanosphere Strikes Gold Recently, scientists at Nanosphere developed a colorimetric method for DNA detection that obviates the need for target or signal amplification. mark for My Articles similar articles
Bio-IT World
September 2005
John Russell
BioSeek's MAP to Discovery Now, after roughly five years of platform development and building a database of assays, BioSeek seems poised for growth. mark for My Articles similar articles
The Motley Fool
May 25, 2007
Brian Orelli
Amylin Sifts for Gold The biotech mines extra value from its compound library. Investors, take note. mark for My Articles similar articles
Bio-IT World
April 16, 2004
Kevin Davies
The Matrix Revolutions Serenex, a company dedicated to drug discovery, uses a proprietary matrix, or affinity media, to bind purine-binding protiens - a process that could transform the drug discovery business. mark for My Articles similar articles
Chemistry World
November 6, 2009
Phillip Broadwith
Enzyme binds both sides of the mirror European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before. mark for My Articles similar articles
Chemistry World
July 26, 2012
Derek Lowe
Screen shots You might not think that the makeup of a compound screening collection could set off many arguments, but there are a few issues there that will do the trick almost every time. mark for My Articles similar articles
Reactive Reports
Issue 41
David Bradley
Chip Chops Time off Drug Discovery Process A next-generation optical screening platform can screen a vast number of compounds rapidly by passing wave after wave of compounds in solution over the surface of the biochip. mark for My Articles similar articles
Chemistry World
October 2008
Derek Lowe
Column: In the pipeline The author seeks a cure for 'compound bloat' mark for My Articles similar articles
Bio-IT World
January 21, 2005
Robert M. Frederickson
High-Throughput Science Although genomic assays led the charge toward high-throughput science, new detection systems and formats are enabling the application of high-throughput techniques to proteins and cells. mark for My Articles similar articles
Chemistry World
June 1, 2012
Derek Lowe
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that. mark for My Articles similar articles
Bio-IT World
May 19, 2004
Julia Boguslavsky
Is Microfluidics Equipped for HTS? As microfluidics technologies mature and increase in throughput, they are starting to offer a highly accurate, flexible, and economical alternative to conventional high-throughput screening (HTS) platforms. mark for My Articles similar articles
Chemistry World
March 23, 2009
Hayley Birch
Speeding up screening for chiral catalysts U.S. researchers say their method represents a 'standard workhorse' for discovery and optimisation of chiral catalysts, such as those widely used by the pharmaceutical and pesticide industries. mark for My Articles similar articles
Technology Research News
March 23, 2005
Nanowires track molecular activity Researchers from Harvard University have found a way to use transistors made from silicon nanowires to gain information about how small molecules bind to proteins. mark for My Articles similar articles
The Motley Fool
September 24, 2007
Billy Fisher
A Fountain of Youth? A study sponsored by Sirtris Pharmaceutical shows potential for the fight against aging. Investors, take note. mark for My Articles similar articles
Bio-IT World
July 2005
Johan Bostrom
Affymetrix to Acquire ParAllele The companies have been working together for the past two years, with Affymetrix using ParAllele's assay technology with the Affymetrix GeneChip technology. Affymetrix expects to strengthen its assay R&D capabilities and add knowledge in specific assay capabilities through the acquisition. mark for My Articles similar articles
Chemistry World
September 29, 2015
Navigating chemical space How big is chemistry? I don't mean how important is it, or how many people do it, but rather, how many molecules are there that we could make? mark for My Articles similar articles
Bio-IT World
July 2005
David M. Evans
Cellular Imaging Takes Drug Discovery to New Heights The potential applications and ultimate value of high-content screening (HCS) and cellular image analysis are limited only by the imagination and expertise of the drug discovery groups using them to probe gene function and cell behavior. mark for My Articles similar articles
Chemistry World
October 25, 2010
Dual Purpose Dyes Offer New Imaging Options US researchers have developed a new series of combined fluorescent and chemiluminescent dye compounds that can be stored at low temperatures and then activated to release near infrared light when warmed to body temperature. mark for My Articles similar articles
Pharmaceutical Executive
May 1, 2001
On Tour with Merck's Robots Merck's HTS robots move assay plates through the screening process. mark for My Articles similar articles
Chemistry World
April 2009
Derek Lowe
Column: In the pipeline The author considers the problems of addressing drug development out of sequence mark for My Articles similar articles
Chemistry World
September 2, 2009
Phillip Broadwith
Shining a light on DNA-binding drugs in living cells German researchers have used standard circular dichroism spectroscopy to probe interactions between drug molecules and DNA within living cells. mark for My Articles similar articles
Pharmaceutical Executive
July 1, 2005
Zaborowski, Hammer & Lawler
Informatics Rules How global computer systems helped far-flung research centers at Roche work together mark for My Articles similar articles
Reactive Reports
December 2006
David Bradley
Biomolecules Out on a Wing Photonic crystals give butterflies their beautiful colors and synthetic versions are now being developed for a range of technological applications. mark for My Articles similar articles
Bio-IT World
December 15, 2004
Kevin Davies
First Trilogy Machine Installed at Mount Sinai A landmark installation for U.S. Genomics' Single Molecule Analyzer. mark for My Articles similar articles
Chemistry World
May 26, 2011
Russell Johnson
Hunting elusive green fluorescent proteins After a 40 year hunt, scientists have tracked down the genes responsible for fluorescent proteins in Obelia medusa - a type of jellyfish. Knowledge of these genes could lead to new fluorescent protein tags for use in cell biology. mark for My Articles similar articles
Bio-IT World
March 2006
Robert M. Frederickson
Integration, Robotics, and Automation The integration of instruments and technology is a key concept driving the development of advanced life-sciences laboratory automation. More sophisticated robotics are also increasingly being integrated into automated systems. mark for My Articles similar articles
Chemistry World
November 3, 2008
Simon Hadlington
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? mark for My Articles similar articles
Bio-IT World
April 15, 2003
Robert M. Frederickson
Protein Chemistry Surfaces Protein chips seek to do for protein expression profiling what DNA chips did for RNA expression. mark for My Articles similar articles
Industrial Physicist Biomimetic Nanotechnology Although biomimetic nanotechnology is in its infancy, with no applications yet reaching commercialization, the barriers in some cases lie mainly in scaling up production processes to industrial levels. mark for My Articles similar articles
The Motley Fool
October 16, 2007
Brian Orelli
Pozen Hedges Its Bets As promised, Pozen and partner GlaxoSmithKline announce that the pair have submitted a response to their approvable letter for Trexima, and that they plan to do an additional just-in-case safety trial. mark for My Articles similar articles
Chemistry World
May 1, 2008
Simon Hadlington
Click chemistry illuminates embryo development US researchers have smuggled modified sugar molecules into a developing zebrafish embryo and then used 'click chemistry' to snap a fluorescent tag onto them to watch cells and tissues forming. mark for My Articles similar articles
D-Lib
Jan/Feb 2010
Rose Holley
Tagging Full Text Searchable Articles: An Overview of Social Tagging Activity in Historic Australian Newspapers August 2008 - August 2009 This article gives an overview of the public reaction to and utilization of the tagging facility in a full-text searchable collection, and provides statistics over a year's duration, observations on the use of tagging and suggestions for future developments. mark for My Articles similar articles
Chemistry World
October 20, 2009
James Urquhart
Gold nanoparticles give super sensitive cancer test The recurrence of prostate cancer could soon be spotted years earlier thanks to a new highly sensitive test developed by US and Austrian researchers. mark for My Articles similar articles
Bio-IT World
September 16, 2004
Michael A. Greeley
Platforms for Pathways Investor interest in the next great blockbuster drug has been blistering hot; Phase II and Phase III compound companies are being funded at a near record-breaking pace now that the IPO window seems to be slightly open mark for My Articles similar articles
The Motley Fool
April 23, 2008
Brian Lawler
Glaxo's Three-Quarter-Billion-Dollar Gamble Glaxo adds another development stage drugmaker to its portfolio. Investors take note. mark for My Articles similar articles
Chemistry World
March 5, 2013
Amy Middleton-Gear
Blink and you'll miss it Scientists in Germany have developed a new method for tracking single fluorescent molecules, using linear programming solvers. mark for My Articles similar articles
Chemistry World
April 14, 2011
Sarah Farley
Fish in chips: growing embryos in microfluidic systems Scientists in the Netherlands and the UK have shown for the first time that an animal embryo can develop in a microfluidic environment. mark for My Articles similar articles
D-Lib
January 2006
Guy & Tonkin
Folksonomies: Tidying up Tags? Possibly the real problem with folksonomies in not their chaotic tags but that they are trying to serve two masters at once; the personal collection, and the collective collection. mark for My Articles similar articles
Chemistry World
June 14, 2012
Nina Notman
A celebration of chemistry Simon Cotton's latest book, Every Molecule Tells a Story, is -- in his own words -- 'a celebration of molecules and of chemistry' aimed at school and university students, and their teachers. mark for My Articles similar articles
Reactive Reports
May 2007
David Bradley
Meeting of Molecular Movie Stars New footage confirms Linus Pauling's theory of chemical bonding proposed half a century ago, and could help explain molecular recognition processes important throughout supramolecular chemistry and molecular biology. mark for My Articles similar articles
Chemistry World
March 9, 2006
Katharine Sanderson
Covalent Bonds Crack Under the Strain Chemists must consider engineering principles when designing molecules following news that tough carbon-to-carbon bonds break easily under mechanical strain. mark for My Articles similar articles