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Chemistry World July 13, 2015 Philip Ball |
First snapshot of elusive intermediate supplies surprise A team near Zurich in Switzerland, has been able to take a single-molecule snapshot of an intermediate in a common class of organic reactions.  |
Chemistry World June 14, 2012 David Bradley |
Tripling up on boron bonds Carbon and nitrogen are well known for their triple bonds, but making stable compounds with a triple bond between two boron atoms hadn't been achieved despite the computational possibilities. Until now.  |
Chemistry World November 27, 2009 Simon Hadlington |
A simple way to join an olefin to an arene Chemists in the US have developed a simple and effective way to carry out a key class of reaction in organic synthesis - the bolting an olefin to an aromatic ring.  |
Chemistry World January 2, 2013 Paul Docherty |
Flueggine A One of the most prolific sources of biologically active natural products is traditional medicines -- whose active components can be exceptionally potent. The Euphorbiaceae family of plants is a productive source of medicinal targets, including the Securinega alkaloids.  |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.  |
Chemistry World March 2012 Paul Docherty |
Column: Totally Synthetic Ring strain is a fascinating phenomenon - one that is best understood with plastic modelling kits, wearing safety specs for ring sizes of four or less.  |
Chemistry World January 2012 Paul Docherty |
Column: Totally Synthetic What a Japanese team demonstrates in this synthesis of dragmacidin D is the state of the art, uniting all the key fragments using C-H bond couplings.  |
Chemistry World March 21, 2007 Richard Van Noorden |
Forcing a Reaction US chemists have forced molecules to react by ripping their bonds apart with ultrasound. The scientists carefully stretched one targeted bond until it snapped, guiding the molecule's subsequent reaction into pathways forbidden by conventional chemistry.  |
Chemistry World June 2011 |
Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan.  |
Chemistry World January 2009 Paul Docherty |
Column: Totally Synthetic In the search for new biologically active natural products, sometimes a team isolating a new compound family will be lucky enough to find one active member.  |
Chemistry World January 8, 2014 Karl Collins |
Oxidation station Small molecules are making significant inroads -- with reactivity and selectivity approaching levels previously thought unachievable.  |
Chemistry World March 2012 |
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug  |
Chemistry World November 5, 2013 Paul Docherty |
Marcfortines B & C Natural product isolation is generally a tale of a journey to an obscure or inaccessible location, followed by pulping a harmless plant or marine sponge to get at compounds made by some bacteria hiding out in the core.  |
Chemistry World October 28, 2013 Edward Anderson |
More dead ends and detours en route to successful total synthesis In this book Miguel A Sierra and his co-authors revisit their 2004 coverage of 'tales of the unexpected' in complex molecule total synthesis.  |
Chemistry World March 22, 2012 Ross McLaren |
Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule.  |
Chemistry World April 2011 Paul Docherty |
Column: Totally Synthetic Reactions in the synthesis of guanacastepene N. Discovered in fungi growing on trees in the Guanacaste conservation area in Costa Rica, several syntheses of this family have appeared in the decade since their isolation.  |
Chemistry World April 2012 Paul Docherty |
Column: Totally Synthetic Detecting rearrangements still seems like an abstract ability for aspiring synthetic chemists. Erick Carreira's synthesis of indoxamycin B is a great case in point, employing two rearrangement reactions.  |
Chemistry World October 2009 |
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions  |
Chemistry World March 24, 2015 Karl Collins |
Back to basics for silylation While silicon is probably most familiar in organic synthesis as part of protecting groups, its utility extends much further.  |
Chemistry World October 11, 2012 Ian Le Guillou |
Turbo-charged Diels-Alder reaction The Diels - Alder reaction is one that sticks in the mind of even the most reluctant chemistry student -- there is a certain elegance in the ring formation from an alkene and diene.  |
Chemistry World May 9, 2010 Phillip Broadwith |
Iron catalyst breaks the mold An iron catalyst that is not only greener than many of its precious metal competitors, but also catalyses reactions that they can't, could open new avenues in transition metal catalysis, say Chinese researchers.  |
Chemistry World July 30, 2013 Paul Docherty |
Melotenine A Chirality, where would we be without you? Often the bane of the synthetic chemist's life, the challenge of asymmetry is perhaps what makes total synthesis so endlessly intriguing.  |
Chemistry World August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now?  |
Chemistry World April 25, 2014 Derek Lowe |
Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found.  |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve.  |
Chemistry World April 2007 Derek Lowe |
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort?  |
Chemistry World October 1, 2014 Karl Collins |
Twisting activity from amides When I think of asymmetric aldol reactions, what immediately springs to mind is using boron to control enolate geometry and chiral auxiliaries to impart facial selectivity in the addition step.  |
Chemistry World December 4, 2009 James Urquhart |
Easier ester synthesis Researchers in the US have shown how oxygen-coated gold nanoparticles can selectively oxidise a variety of alcohols and aldehydes.  |
Chemistry World August 2, 2013 Amy Middleton-Gear |
Homogeneous catalyst made to act more like an enzyme Homogeneous catalytic systems which display selectivity in a mixture of similar substrates are rare. Now scientists have shown that encapsulating a homogeneous catalyst in a supramolecular host can give it a more discerning nature.  |
Chemistry World September 25, 2015 Derek Lowe |
Spice up your compounds You and your team are optimizing a lead compound, as medicinal chemists are wont to do -- varying its structure to improve its potency, selectivity and other properties.  |