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Chemistry World March 10, 2006 |
Dual Organometallics Enhance Zinc Reactivity Chemists have synthesised organometallic compounds that enable zinc to participate in directed metalation of organic substrates.  |
Chemistry World April 12, 2012 Simon Hadlington |
Recruiting electrophiles for organic cross-coupling Chemists in the US have taken an unconventional approach to carbon cross-coupling and in doing so have potentially opened the door to the rapid and efficient synthesis of a wide range of organic compounds.  |
Chemistry World September 24, 2009 Phillip Broadwith |
Carbon can't but tin can US chemists have discovered that distannynes - tin-based analogues of acetylenes - can react reversibly with ethene to make cyclic complexes.  |
Chemistry World March 2, 2015 Andy Extance |
Chemists zinc up 'aromatic' metal cubes Researchers in China and the US have synthesized polyzinc clusters that have pushed back the boundaries of the kind of aromatic structures chemists can make.  |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions.  |
Chemistry World November 2010 |
Carbon Couplers Take the Prize Three giants of organic chemistry, who pioneered palladium-catalysed cross coupling reactions, have shared this year's Nobel prize.  |
Chemistry World December 5, 2012 Phillip Broadwith |
Chemical reactions in hot water Chinese and Japanese chemists have highlighted hot water's ability to promote unexpected reactions without any other reagents or catalysts. The work should expand our understanding of how to harness the physicochemical properties of water to potentially replace more complex reagents and catalysts.  |
Chemistry World November 8, 2007 James Mitchell Crow |
First Mg(I) Complex Made Chemists have created the first stable magnesium(I) compounds, a breakthrough for a metal whose chemistry is ruled by the oxidation state.  |
Chemistry World August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now?  |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.  |
Chemistry World November 7, 2013 Polly Wilson |
Hydrogen adopts alkali metal position For the first time, scientists have shown that hydrogen can stand in for alkali metals in typical alkali metal structures.  |
Chemistry World October 2009 |
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions  |
Chemistry World June 2007 Dylan Stiles |
Opinion: Bench Monkey This PhD student takes an organic chemist's tour around the periodic table.  |
Chemistry World March 20, 2007 Tom Westgate |
Is Your Lab Ready to go Veggie? In a recently published review article, Geoffrey Cordell demonstrates that the greengrocer's could be an unexpected goldmine of sustainable, cheap reagents that would benefit chemistry in developing countries.  |
Chemistry World February 6, 2011 Laura Howes |
Cells as test tubes Chemists have used living cells as test tubes to carry out chemical reactions never before seen within living cells.  |
Chemistry World July 8, 2010 Phillip Broadwith |
Flattening carbon UK researchers have managed to synthesise a molecule with an almost planar four-coordinate carbon atom bonded to two lithium atoms and bulky organic ligands.  |
Chemistry World June 2008 Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success  |
Reactive Reports December 2006 David Bradley |
Dick Wife An interview with the chemical IT scientist and co-founder of SORD, a scientific publishing company that seeks to solve the problem of organizing the myriad of undocumented chemistry and the chaotic mess of the commercial database.  |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve.  |
Chemistry World April 25, 2014 Derek Lowe |
Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found.  |
Chemistry World February 2008 Dylan Stiles |
Column: Bench Monkey Cast a skeptical eye over new ideas in chemistry.  |
Chemistry World January 2, 2013 Derek Lowe |
Fear of the unknown My mental file drawer labelled 'Terrible Reagents I Have Known' is even larger than the one called 'Lunatics I Have Worked With and their Life-Threatening Ideas'. We organic chemists really do work with some terrible chemicals, and it's up to us to keep them from causing havoc.  |
Chemistry World January 25, 2013 Derek Lowe |
Name reactions: how does the label stick? Some of these names go back to the 19th century, and many more of them come from the first decades of the 20th. Once in a while, I wonder if the tradition is dying out. Are we still naming chemical reactions after their discoverers?  |
Chemistry World August 2009 Derek Lowe |
Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder  |
Chemistry World June 2011 |
Column: In the pipeline Chemists are human. Humans are hierarchical. Therefore...well, therefore, you'll find a number of different roles and levels for scientists in a drug company's labs. Here's a rough ordering, from least experienced to most.  |
Chemistry World August 22, 2014 Derek Lowe |
Death of a reagent Anyone who's been practicing organic chemistry for a while can think back to reactions and reagents that were once in far wider use than they are today.  |
Chemistry World November 2007 Derek Lowe |
Column: In the Pipeline Chemists are finally going with the flow.  |
Chemistry World September 26, 2012 Derek Lowe |
Under pressure Someone interviewing for a synthetic chemistry position had better know his or her organic chemistry. It's fair to ask questions that will make sure of that. But does a candidate need to know the curly-arrow details of reactions that they'll never run?  |
Chemistry World March 2012 |
Column: In the pipeline Drug discovery requires experimentation, says Derek Lowe. But chemists can be reluctant to stray from the elements they know and love  |
Chemistry World October 2007 Derek Lowe |
In the Pipeline One of the biggest areas of chemical research these days is in catalytic processes. It's one of the places we can really improve our processes, especially when you count the waste stream (as you should) as part of the total energy bill.  |
Chemistry World September 7, 2014 Michael Gross |
Bringing chemical synthesis to the masses The promise of a novel approach to building chemical libraries, which only requires simple building blocks in water, without any additional reagents or sample preparation, is inspired by nature.  |
Chemistry World June 1, 2012 Derek Lowe |
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that.  |
Chemistry World October 2008 Derek Lowe |
Column: In the pipeline The author seeks a cure for 'compound bloat'  |
Chemistry World February 7, 2010 Kate McAlpine |
Closure on a knotty problem Nine years ago, Chris Hunter's group at the University of Sheffield in the UK reported that they could use a zinc ion to tie an open knot in a linear oligomer.  |
Reactive Reports Issue 67 David Bradley |
Multichannel Microchemical Factory The microchemical factory approach offers a safer and scaleable approach to producing materials from the very smallest quantities to the largest bulk.  |
Chemistry World January 13, 2011 Sarah Corcoran |
Unclogging the problems of flow chemistry US scientists have found a way to stop solid byproducts clogging channels in continuous flow reactors, a problem that has hampered their progress for use in manufacturing pharmaceuticals.  |
Chemistry World April 2011 |
Column: In the Pipeline If you look over the whole pharmacopeia, you'll see there are a lot of compounds that got their start as natural products.  |
Chemistry World October 15, 2012 John Hayward |
Oxidizing agents Oxidation in Organic Synthesis by V.K .Ahluwalia contains an extensive list of reagents and is of some interest as a reference resource, particularly with respect to some of the more exotic reagents.  |
Chemistry World February 15, 2011 Mary Badcock |
Building up a natural product toolkit US scientists have come up with a method that makes it easier to extract compounds that are difficult to isolate from crude natural product mixtures.  |
Chemistry World October 2010 |
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery  |
Chemistry World July 2, 2014 Victoria Richards |
Molecular brass Brass has been known to man since prehistoric times; now scientists in Germany have isolated the first molecular example of the copper -- zinc alloy.  |
Chemistry World December 10, 2014 |
Big pharma opens up abandoned drugs Sixty eight stalled pharmaceutical compounds are being made available for academic research through the UK Medical Research Council.  |
Chemistry World December 2008 |
Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project.  |