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Chemistry World June 17, 2013 Eleanor Merritt |
Switching chirality in amino acids An international team of scientists has developed a purely chemical approach to interconvert L- and D-amino acids. This method could rival enzymatic routes used in industry, and enable cheaper production of some pharmaceuticals.  |
Chemistry World September 6, 2006 Michael Gross |
Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses.  |
Chemistry World August 16, 2009 Tom Bond |
Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis.  |
Chemistry World January 6, 2013 Simon Hadlington |
Greener route to carboxylic acids Chemists in Israel have developed a new way to oxidize primary alcohols to carboxylic acids, using water as both the reaction solvent and the source of oxygen.  |
Chemistry World July 15, 2010 Simon Hadlington |
Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit.  |
Chemistry World February 19, 2010 Simon Hadlington |
Forcing stereoselectivity on reactive cations Chemists in the US have devised a dual catalyst strategy to tame the highly reactive iminium ion to give a high degree of stereochemical control over subsequent reactions of the ion.  |
Chemistry World November 1, 2009 Hayley Birch |
How light gave life a helping hand A new theory for how 'handedness' in organic molecules evolved has been proposed by Dutch scientists.  |
Chemistry World July 2, 2014 Tim Wogan |
Miller's forgotten experiments point to primitive protein genesis Stanley Miller's experiments are still adding to our understanding of prebiotic Earth.  |
Chemistry World April 8, 2008 Mark Peplow |
Meteorite Source for Life's Handedness Scientists have long speculated that life's preference for left-handed amino acids may have been triggered by compounds brought to Earth by meteorites. Now they've shown exactly how two crucial steps in this process could happen.  |
Chemistry World July 16, 2013 Harriet Brewerton |
Accelerating stereochemical analysis A chemosensor has been developed by scientists in the US to speed up the quantitative stereochemical analysis of chiral amino alcohols and diamines.  |
Chemistry World September 20, 2007 Lewis Brindley |
New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction.  |
Chemistry World March 2, 2007 Philip Ball |
Giving Life a Hand Why are proteins left-handed and nucleic acids right-handed? Once offered only a few sketchy theories, scientists have found more alternatives for creating homochirality.  |
Chemistry World March 14, 2014 Simon Hadlington |
Chemists make headway on C--H activation challenges Jin-Quan Yu's group at the Scripps Research Institute at La Jolla, California, have synthesized a library of synthetic chiral amino acids which could have applications in the pharmaceutical industry.  |
Chemistry World February 21, 2008 Lewis Brindley |
Esters Made Easy with Indium Indium is the basis of a novel catalyst designed to make useful cyclic esters. This catalyst could greatly simplify the production of chiral dihydropyranones, important structural elements in many natural products and pharmaceuticals.  |
Chemistry World June 17, 2009 Hayley Birch |
Acrylic beads promise scalable organocatalyst production Norwegian scientists have developed a new, more efficient approach to synthesizing polymer beads containing proline and its derivatives, for use in organocatalysis.  |
Chemistry World March 25, 2011 Simon Hadlington |
New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists.  |
Chemistry World June 5, 2012 Simon Perks |
Chiral separation with micro-flows How do you separate enantiomers without any kind of chiral recognition between molecules? The answer it seems is to use asymmetric flow in a micro-fluidic channel.  |
Chemistry World July 26, 2007 Richard Van Noorden |
Shortcut Protein Synthesis Ditches Amino Acids Chinese chemists have demonstrated a speedy way to make polypeptides by avoiding the costly tedium of linking together amino acids.  |
Chemistry World June 1, 2006 Michael Gross |
New Twists on Catalysis Chemists around the world have discovered several new twists to improve the performance of asymmetric catalysts in hydrogenation reactions.  |
Chemistry World June 13, 2008 Richard Van Noorden |
Asymmetric ketone catalysis gets pharma-scale makeover An asymmetric catalysis reaction limited to laboratory syntheses has received a makeover that could see it used on a large scale by drug-makers.  |
Chemistry World July 6, 2015 Abigail Hallowes |
From chip fat to biofuel Researchers from Singapore and China have developed a cheap and green catalytic system for turning fatty acids into fuel that doesn't require hydrogen or a solvent.  |
Chemistry World April 28, 2010 Mike Brown |
Producing hydrogen from sea water A new catalyst that generates hydrogen from sea water has been developed by scientists in the US.  |
Chemistry World November 17, 2008 Simon Hadlington |
Catalyst flexes for extra control US chemists have developed a new type of catalyst capable of exerting high stereochemical control over olefin metathesis reactions  |
Chemistry World November 3, 2011 Erica Wise |
A Model for the Single Chirality of Life The boiling solutions in prebiotic hot springs could shed light on the emergence of a single chiral form of biomolecules in nature, say Spanish scientists.  |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?  |
Chemistry World November 26, 2010 Amaya Camara-Campos |
Enriching the origin of life theory An enantioenrichment of the amino acid valine, which could shed light on the origin of chirality on Earth, has been achieved by scientists in Spain.  |
Chemistry World May 15, 2014 Jenifer Mizen |
Freeze-dried cells make better biocatalysts A biocatalytic cascade using mashed-up cells has overcome extraction and solubility problems associated with using enzymes in chemical syntheses.  |
Chemistry World August 7, 2011 Phillip Broadwith |
Possible Origin of Chirality in the Rna World Given a tiny push one way or the other, simple racemic precursors can lead to the chiral building blocks of RNA using a combination of chemical and physical factors.  |
Chemistry World October 18, 2011 Steve Down |
Cofactor Control of Catalysis Enantioselectivity Scientists have used cofactors to control the enantioselectivity of supramolecular transition metal catalysts, enabling the asymmetric hydrogenation of a series of acrylates and related compounds with remarkably high selectivities.  |
Chemistry World April 19, 2009 Hayley Birch |
Chiral metals shape up for catalysis Dutch and Israeli scientists have found a way to induce the chirality usually only found in organic materials in palladium.  |
Chemistry World December 17, 2009 Simon Hadlington |
Single catalyst gives two products from racemic mixture Chemists in the US have demonstrated a remarkable reaction in which a single catalyst can transform a racemic mixture - molecules identical in every way except for their chirality - into two distinct enantiomerically pure products.  |
Chemistry World September 4, 2008 Fred Campbell |
Two catalysts better than one US researchers have cracked a long standing problem in chemical synthesis - the catalytic alpha-alkylation of aldehydes - by combining two catalysts in one pot.  |
Chemistry World May 26, 2015 Victoria Richards |
Crystalline sponge method strikes again Scientists from Japan report that their revolutionary crystallographic technique has determined the stereochemistries of molecules with axial and planar chiralities, where classical methods had failed.  |
Chemistry World March 6, 2008 Simon Hadlington |
Synthetic Enzymes Designed by Computer Scientists in the US have designed and built an artificial enzyme from scratch.  |
Chemistry World May 30, 2013 Andy Extance |
Catalyst duo exerts powerful stereocontrol Chemists from the Swiss Federal Institute of Technology, ETH Zurich, have teamed chiral catalysts in pairs to selectively drive a reaction towards desired stereoisomeric products with high selectivity.  |
Chemistry World April 1, 2011 Hayley Birch |
Nanoparticles help reveal hidden fingerprints A technique using gold nanoparticles in combination with antibodies has shown promising results for enhancing fingerprints that are over a week old.  |
Chemistry World April 9, 2010 Mike Brown |
Going for silver: green plastic production Scientists in the US have identified a new class of catalyst based on subnanometer clusters of three silver atoms that could provide a greener route to propylene oxide - a key intermediate used to make thousands of everyday products  |
Chemistry World February 13, 2013 James Mitchell Crow |
Tapping proton power for enantioselective synthesis A simple proton is the key to a novel approach by US-based chemists to synthesize chiral amines and alcohols -- a structural motif common to many organic molecules with pharmaceutical promise.  |
Chemistry World January 21, 2011 David Barden |
Close encounter makes modifying proteins easy Chemists in the US have now developed a powerful strategy for selectively modifying the side-chains of proteins, which they hope will enable the creation of new tools to investigate protein interactions involved in human diseases.  |
Chemistry World March 23, 2009 Hayley Birch |
Speeding up screening for chiral catalysts U.S. researchers say their method represents a 'standard workhorse' for discovery and optimisation of chiral catalysts, such as those widely used by the pharmaceutical and pesticide industries.  |
Chemistry World October 12, 2015 Andy Extance |
'Chemical search engine' backs alternative route to life A key class of biological molecules neglected in the search for life's chemical origins could have appeared spontaneously before organisms, UK scientists say.  |
Chemistry World December 23, 2015 Karl Collins |
Scratching chiral surfaces There are numerous challenges to developing reactions that exploit chiral surfaces, or employ molecular modifiers (ligands) to create a chiral surface environment and control the stereoselectivity of a transformation.  |
Chemistry World November 3, 2014 Debbie Houghton |
Engineered metalloenzyme catalyses Friedel -- Crafts reaction Reprogramming the genetic code of bacteria to incorporate an unnatural amino acid has allowed scientists in the Netherlands to create a new metalloenzyme capable of catalyzing an enantioselective reaction.  |
Chemistry World March 8, 2011 Jon Cartwright |
Carbon nanotubes - a boon for chiral catalysts Researchers in China have created a new catalyst that could help in the production of chiral molecules for medical drugs. The catalyst, which consists of platinum nanoparticles encapsulated in carbon nanotubes, is the most active of its type ever reported.  |
Chemistry World October 26, 2006 Victoria Gill |
Volcanoes Reveal the Secret of the Origin of Life Life began with a chemical reaction under the sea over four billion years ago. That is the claim of a German scientist whose team has recreated a crucial part of the reaction, synthesizing all the necessary ingredients for a living organism.  |
Chemistry World July 26, 2007 Tom Westgate |
Counterion Does the Twist US chemists have achieved a breakthrough in the design of catalysts that selectively produce chiral compounds.  |
Chemistry World March 30, 2011 Hayley Birch |
Amino acid synthesis hints at how the genetic code expanded The detailed pathway for the biosynthesis of pyrrolysine - the 22nd and latest amino acid to be discovered - has been outlined by US researchers.  |
Chemistry World August 13, 2015 Heather Powell |
Study probes role of chemical corruption in origin of life Researchers are incorporating what they describe as defective compounds into their experiments to help them understand how the first molecules of life formed.  |
Chemistry World May 21, 2009 James Urquhart |
Catalyst kinetics revealed French and UK scientists have developed a spectroscopy technique that has elucidated the reaction mechanism of a silver-alumina catalyst.  |
Chemistry World August 22, 2014 Derek Lowe |
Death of a reagent Anyone who's been practicing organic chemistry for a while can think back to reactions and reagents that were once in far wider use than they are today.  |