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Chemistry World August 25, 2011 Holly Sheahan |
New Source of Tamiflu Japanese scientists have discovered a new way of obtaining shikimic acid, the compound needed to make the influenza drug Tamiflu.  |
Chemistry World November 2007 Dylan Stiles |
Column: Bench Monkey Total synthesis is not immune to the vagaries of fickle fashion.  |
Chemistry World November 27, 2008 Lewis Brindley |
Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially.  |
Chemistry World August 25, 2011 David Barden |
Rapid Route to Huperzine A US chemists have devised an efficient synthesis of a natural product with great potential as a protectant against chemical warfare agents and in the treatment of Alzheimer's disease.  |
Chemistry World May 13, 2015 Andy Extance |
Espresso maker brews up tasty extraction Researchers in Australia have used an unmodified household espresso maker to get nearly pure shikimic acid -- a raw material for Roche's antiviral drug Tamiflu -- from the spice star anise.  |
Chemistry World August 1, 2013 James Urquhart |
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions.  |
Chemistry World August 30, 2009 Phillip Broadwith |
C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules.  |
Chemistry World June 11, 2008 James Mitchell Crow |
New Hope for Anticancer Agent The mode of action of a rare natural product with promising cytotoxic activity has been revealed by scientists in the US while a UK group have come up with a particularly efficient chemical synthesis.  |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve.  |
Chemistry World July 14, 2011 Simon Hadlington |
Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor.  |
Chemistry World December 2008 Paul Docherty |
Column: Totally Synthetic Pseudolaric acid B: regular readers of this column's online incarnation will have noticed that this is the second appearance for this particular synthesis.  |
Chemistry World March 25, 2011 Simon Hadlington |
New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists.  |
Chemistry World February 2011 Paul Docherty |
Column: Totally Synthetic Although most of the natural products I've discussed have had biological activity at the core of the rationale for their synthesis, most organic chemists will admit that an unusual chemical structure is by far the stronger draw.  |
Chemistry World January 21, 2013 Michael Parkin |
Flow synthesis for anticancer drug UK chemists have used a combination of flow chemistry methods with solid-supported scavengers and reagents to synthesize the active pharmaceutical ingredient, imatinib, of the anticancer drug Gleevec.  |
Chemistry World April 5, 2013 Phillip Broadwith |
Roche to release Tamiflu trial data Swiss pharma company Roche has finally agreed to give independent researchers access to data on all 74 clinical trials it ran on the antiviral influenza drug Tamiflu (oseltamivir).  |
Chemistry World July 27, 2015 |
(--)-Jiadifenolide I believe that Ryan Shenvi's could well be the last synthesis we see of the popular neurotrophic agent jiadifenolide, at least for some time.  |
Chemistry World April 2007 Derek Lowe |
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort?  |
Chemistry World October 1, 2012 Paul Docherty |
Prostaglandin F2I There's been no shortage of grant funding for synthetic chemistry of the prostaglandins, keeping some of the finest minds in organic chemistry engaged over the last five decades.  |
Chemistry World September 2008 Derek Lowe |
Column: In the pipeline The author remembers leaving the ivory towers of academe to trade 'unusual and beautiful' for 'useful'  |
Chemistry World February 2011 |
Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential  |
Managed Care November 2002 |
Flu season: Most HMO formularies cover Tamiflu, Relenza As the influenza season approaches, managed care patient access to Tamiflu (oseltamivir) from Roche Laboratories and Relenza (zanamivir) from GlaxoSmithKline, the two medications indicated for influenza, looks relatively open.  |
Chemistry World May 14, 2008 Simon Hadlington |
Bird Flu's Drug Resistance Mapped UK scientists have shown exactly why a mutant version of the deadly bird flu virus H5N1 becomes resistant to the drug oseltamivir - marketed as Tamiflu.  |
Chemistry World November 27, 2012 Andrew Turley |
Roche and the Tamiflu data The Swiss pharma company has agreed to talk to external groups about full access to data for antiviral Tamiflu (oseltamivir) tablets, according to a letter published by the British Medical Journal.  |
Chemistry World November 16, 2012 Yuandi Li |
(+)-Myrrhanol C made Spanish chemists have completed the stereospecific total synthesis of (+)-myrrhanol C. This compound is a natural triterpene isolated from mastic gum, a substance well known for its medicinal properties as well as use in various cuisines.  |
Chemistry World June 2010 Paul Docherty |
Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups.  |
The Motley Fool October 17, 2005 Brian Gorman |
Chasing Down Bird Flu Sanofi and GlaxoSmithKline are emerging as the likely winners in the race to produce a bird flu vaccine.  |
Chemistry World December 2009 Paul Docherty |
Column: Totally Synthetic What turns a good synthesis into a great synthesis are the steps surrounding that motif, something that Darren Dixon from the University of Oxford, UK, exemplifies with this synthesis of Nakadomarin A.  |
Chemistry World August 2010 Paul Docherty |
Column: Totally Synthetic The total synthesis of macrolide targets is now a relatively mature field. Any synthesis that bucks these trends grabs attention, with a recent publication of dictyosphaeric acid A by Richard Taylor's team at the University of York, UK, a case in point.  |
Chemistry World May 23, 2011 James Mitchell Crow |
Hatching a plan to kill worm pests A parasitic pest that can devastate entire fields of vegetable crops is a step closer to being brought under control, thanks to the synthesis of a compound that tricks its eggs into hatching early.  |
Chemistry World November 24, 2011 Elinor Richards |
Blocking cancer's path A concise synthesis of the natural product rasfonin could reignite interest in this molecule as a tool to develop cancer drugs, say scientists from the Netherlands.  |
The Motley Fool February 4, 2010 Brian Orelli |
Glaxo Brings Home the Bacon Swine flu gives GlaxoSmithKline the boost, but how long will it last?  |
Chemistry World January 7, 2014 Angeli Mehta |
Flu drug stockpile may be worthless The case for spending hundreds of millions of pounds stockpiling antivirals for use in a flu pandemic is based on 'judgement rather than on evidence of their effectiveness', according to a parliamentary committee.  |
Chemistry World December 17, 2012 Jessica Cocker |
Helping the fight against flu Scientists from Australia and the US have developed a synthesis for a drug that gives higher yields and antiviral activity than currently used commercial drugs, such as Relenza (zanamivir) and Tamiflu (oseltamivir), they claim.  |
Chemistry World February 6, 2014 Simon Lewis |
Design and strategy in organic synthesis In this comprehensive treatise by Hanessian and others, a wide range of total syntheses from many different laboratories is used to exemplify different approaches to synthetic design.  |
Chemistry World July 24, 2009 Matt Wilkinson |
Pharma's shot in the arm? As swine flu cases continue to erupt around the globe, the latest financial results from pharmaceutical companies Roche and GlaxoSmithKline reveal that sales of their antiviral drugs have soared.  |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?  |
Reactive Reports Issue 73 David Bradley |
Fake Bird Flu Chemists have developed a rapid technique for detecting fake Tamiflu, the mainstay medication for preventing and treating bird flu.  |
Chemistry World February 2012 Paul Docherty |
Column: Totally Synthetic Medium rings are a beguiling feature found in a host of natural products, owing to their behavioral oddities.  |
Chemistry World July 2009 Paul Docherty |
Column: Totally Synthetic When it comes to making large natural products, different researchers will often propose identical 'end-game' strategies to complete the target.  |
The Motley Fool March 16, 2006 Rich Duprey |
Avian Flu Ruffling Feathers Roche Pharmaceuticals boosts anti-flu drug production to quiet calls for generics. While the situation bears watching for now, it's not necessarily something for investors to get their feathers ruffled about.  |
The Motley Fool April 27, 2009 Brian Orelli |
A Capitalist Pig's View of Swine Flu So you want to make money from the swine flu? Here's how to do so.  |
Chemistry World June 2008 |
Column: In the pipeline The author, a medicinal chemist working on preclinical drug discovery, takes a look at the differences between chemists and biologists working on the same team.  |
The Motley Fool March 30, 2006 David Compton |
Glaxo's New Flu-Fighting Ammo The FDA certifies the drugmaker's Relenza for defense as well as offense. For investors seeking to give their portfolios a shot in the arm, now might be the time to take a closer look at Glaxo.  |
Chemistry World October 28, 2013 Edward Anderson |
More dead ends and detours en route to successful total synthesis In this book Miguel A Sierra and his co-authors revisit their 2004 coverage of 'tales of the unexpected' in complex molecule total synthesis.  |
Chemistry World May 2011 Paul Docherty |
Column: Totally Synthetic The ability to understand molecular structure is perhaps both our greatest skill and largest encumbrance as scientists. A quick glance at the structure of a target such as nanolobatolide tells us much about its connectivity and the manner in which it might react.  |
The Motley Fool July 22, 2009 Brian Orelli |
Grab Hold of This Growth Double-digit growth just keeps coming for Gilead Sciences.  |