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Bio-IT World September 2006 Kevin Davies |
Pfizer's Global Survey of Pharmacological Space The pharma blends knowledge, computational chemistry and research informatics to build a unified database. Gathering all the data in one place offered greater control for indexing and data retrieval and management, enabling Pfizer scientists to perform global mapping.  |
Bio-IT World May 19, 2004 John Russell |
Informatics Black Boxes ... Not! Vertex's chief technical officer, discusses informatics' bad reputation, buying vs. building, open-source tools, and ROI on IT.  |
Chemistry World August 13, 2015 |
Exploiting the data mine Chemists must embrace open data to allow us to collectively get the best out of the masses of new knowledge we unearth, reports Clare Sansom  |
Bio-IT World November 2006 Kevin Davies |
Jubilant Curries Favor with BioPharma The explosion of drug discovery and development operations in India is epitomized by the success of several companies. Quietly building on a decade of experience in computational and bio-IT fields, JBL is rapidly pushing into a suite of drug discovery and development activities.  |
Bio-IT World January 13, 2003 John Dodge |
Managing Innovation and Adversity ArQule CIO Alan Hillyard's database migration project became more challenging -- and more important -- following recent layoffs. The good news is that progress continues.  |
Bio-IT World June 17, 2004 Mark D. Uehling |
How to Spell Discovery Rapidly combining cosmos of chemical and biological data, Johnson & Johnson's multidisciplinary ABCD platform for drug discovery aims to give scientists access to more information -- and the ability to make better decisions  |
Bio-IT World January 21, 2005 |
Defining 'Integrative Genomics' Five experts from academia and industry discuss the burgeoning field of integrative genomics.  |
Bio-IT World April 15, 2003 Mark D. Uehling |
Target Elimination Industry and FDA scientists turn to databases, applications software, and laboratory chips to move the safest, most effective molecules into clinical trials.  |
Chemistry World June 2008 Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success  |
Chemistry World September 29, 2015 |
Navigating chemical space How big is chemistry? I don't mean how important is it, or how many people do it, but rather, how many molecules are there that we could make?  |
Chemistry World May 22, 2013 |
Notebooks go digital Electronic lab notebooks are changing the way many scientists interact with information. These notebooks, ELNs for short, capture experiment details and data that are fully searchable within and across experiments.  |
Reactive Reports Issue 74 David Bradley |
Reactive Profile--Noel O'Boyle Interview with a Postdoctoral Research Associate in the Development Group working on drug discovery, protein-ligand docking, cheminformatics, QSAR, and computational chemistry.  |
Chemistry World March 5, 2015 Emma Stoye |
Forgotten synthetic PhD theses set to be given new lease of life A team of researchers have amassed a digital collection of more than 75,000 compounds from PhD theses that might otherwise have mouldered in obscurity.  |
Bio-IT World December 10, 2002 Arielle Emmett |
Locus Focus Cheminformatics company Locus Discovery is a technology darling and an entrepreneur's dream, but it faces a dilemma over how much of its proprietary drug discovery software and data to reveal.  |
Bio-IT World November 19, 2004 Kevin Davies |
De-Lovely Pharmaceuticals De Novo Pharmaceuticals identifies novel compounds right before your eyes.  |
Reactive Reports Issue 57 |
Interview with Andrew Lemon With a background in Chemistry and a keen sense of business, this co-found of The Edge Software Consultancy helps global pharmaceutical companies increase the efficiency and productivity of their software tools.  |
CIO October 15, 2001 Stephanie Overby |
Drug Companies on speed The marriage of IT and medical research may be just what traditional pharmaceutical companies need to survive in an increasingly competitive field. Learn how IT is bringing the pharmaceutical industry into the information age...  |
Chemistry World May 20, 2015 Katrina Kramer |
Taking the lead on drug discovery Researchers from the UK have developed a straightforward strategy for making compounds that have the potential to become clinical drugs.  |
Chemistry World October 2010 |
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery  |
Chemistry World January 2008 Philip Ball |
Column: The Crucible Does chemical space limit a chemists' creativity?  |
Reactive Reports Issue 55 David Bradley |
Interview with Wendy Warr This well-known and well-respected expert in the field of chemical information creates online reports and opinions that are essential reading for chemists hoping to understand the changes in information that are currently underway.  |
ONLINE Sep/Oct 2007 Svetla Baykoucheva |
A New Era in Chemical Information: PubChem, DiscoveryGate, and Chemistry Central How the emergence of PubChem, DiscoveryGate and Chemistry Central are changing the field of chemical information.  |
Chemistry World December 2008 |
Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project.  |
Chemistry World December 2007 Richard Van Noorden |
Surfing Web2O The rapid evolution of the world wide web is creating fresh opportunities - and challenges - for chemistry.  |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve.  |
Bio-IT World February 10, 2003 Malorye Branca |
Conquering Infinity with Chemical Genetics Harvard superchemist Stuart Schreiber defines the convergence of chemistry and biology. Now the field of chemical genetics is heading toward the clinic.  |
Bio-IT World September 2006 Mike May |
Working Out the Flow Better management of workflow issues in biotech and pharma could change fundamental aspects of these sciences in the near future.  |
Reactive Reports November 2005 David Bradley |
Peter Murray-Rust An interview with the scientific software developer, originally a crystallographer with a DPhil from Oxford, on how he is now helping to establish novel software and Web technologies for chemists and other scientists underpinned by the concept of open source.  |
Chemistry World October 2008 Derek Lowe |
Column: In the pipeline The author seeks a cure for 'compound bloat'  |
Chemistry World November 28, 2013 |
Put the chemistry back in medicinal chemistry Today, synthetic skill is valued and appreciated much less in medicinal chemistry than in chemical development, though it is equally important for both. Much of the blame lies with the mismeasurement of productivity.  |
Bio-IT World June 17, 2004 John Garvey |
Rational Decisions As companies in the computationally guided rational drug design sector mature, they should be more sure of the boundaries that surround their proprietary technologies.  |
Chemistry World December 16, 2013 Anthony King |
Database of 15 million chemical structures set free A collection of over 15 million chemical structures from patents -- SureChem -- is to be made freely available through the European Bioinformatics Institute.  |
Chemistry World April 25, 2013 Andreas Barth |
Chemical bibliometrics Counting compounds instead of publications and citations opens new perspectives for data-based scientific discovery and it can complement and stimulate both experimental and theoretical research.  |
Bio-IT World October 14, 2004 Salvatore Salamone |
Riding the New Wave New offerings from Accelrys, LION bioscience, MDL, Synthematix, and Tripos may be the crest of a new wave of software designed to meet increasing demand to incorporate chemoinformatics into the drug discovery process.  |
Chemistry World April 2011 |
Molecular Obesity is Weighing Down Drug Discovery Medicinal chemistry's quest for potent drug candidates has resulted in molecules that are too large and too lipophilic for their own good.  |
Bio-IT World August 18, 2004 Kevin Davies |
In Praise of Chemical Diversity How to build better small-molecule libraries.  |
Bio-IT World Dec 2006/Jan 2007 Giacomo Bastianelli |
The Future of Predictive Biology Predictive biology, data and the integration of disparate research disciplines are key ingredients for the future of drug discovery research and healthcare.  |
Chemistry World December 2010 |
A structure-based community for chemists ChemSpider, a free online database of chemicals and related information, has delivered an online environment for the community to both deposit their data as well as curate and annotate existing content on the database.  |
Bio-IT World April 16, 2004 Malorye Branca |
Finding the Perfect Fit Fragment-based drug discovery is unique and effective.  |
Chemistry World June 1, 2012 Derek Lowe |
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that.  |
Chemistry World February 8, 2006 Jon Evans |
To Boldly go Where no Chemist Has Gone Before Studying the interactions between different molecular fragments is taking researchers to the uncharted regions of chemical space.  |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions.  |
Bio-IT World November 12, 2002 James Golden |
The Business of Bioinformatics The industry has reached an interesting crossroads. As an academic branch of learning, bioinformatics remains mostly what it always was, a cross-disciplinary endeavor between computer science and molecular biology. But bioinformatics as a money-making proposition has different criteria for success.  |
Reactive Reports December 2006 David Bradley |
Dick Wife An interview with the chemical IT scientist and co-founder of SORD, a scientific publishing company that seeks to solve the problem of organizing the myriad of undocumented chemistry and the chaotic mess of the commercial database.  |
Chemistry World May 2010 |
Mobile chemistry - chemistry in your hands and in your face Mobile chemistry has arrived. This short article will review some of the available tools and offers a view of what the near term future may hold for this domain.  |
Chemistry World March 2012 |
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug  |
Information Today May 5, 2011 Robert E. Buntrock |
SciPlanner: Latest Addition to the CAS Suite of Programs In over a century of existence, Chemical Abstract Service has become the premier source of chemical information.  |
Chemistry World November 30, 2012 Andy Extance |
Chemists cull compounds using 'intuition' Medicinal chemists might be using far fewer parameters to choose candidate fragments for a screening collection than they think they do. Their choices can be mimicked based on just one or two properties, a team led by researchers at Swiss-headquarted pharmaceutical firm Novartis has found.  |
Chemistry World July 2008 Kevin Rogers |
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril  |
HHMI Bulletin Nov 2011 Sarah C. P. Williams |
Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems.  |