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Bio-IT World January 21, 2005 |
Defining 'Integrative Genomics' Five experts from academia and industry discuss the burgeoning field of integrative genomics.  |
Bio-IT World November 2006 Robert M. Frederickson |
Managing Data on the Go GeneGo has created a suite of software and database products that aim to facilitate analysis of the biology behind different types of high-throughput experimentation and understand the effects of small molecule drug compounds in human tissues.  |
Bio-IT World July 2005 David M. Evans |
Cellular Imaging Takes Drug Discovery to New Heights The potential applications and ultimate value of high-content screening (HCS) and cellular image analysis are limited only by the imagination and expertise of the drug discovery groups using them to probe gene function and cell behavior.  |
Bio-IT World February 10, 2003 Malorye Branca |
Conquering Infinity with Chemical Genetics Harvard superchemist Stuart Schreiber defines the convergence of chemistry and biology. Now the field of chemical genetics is heading toward the clinic.  |
Bio-IT World Jul/Aug 2006 Deb Janssen |
Managing the Microarray Data Mountain Genomic studies often involve thousands of samples and require hundreds of thousands of assays per sample. Microarray manufacturers are scurrying to satisfy researcher demands for increased array density, sample number, and content flexibility.  |
Industrial Physicist Jennifer Ouellette |
Bioinformatics moves into the mainstream An explosion of data is being tamed with new systems  |
CIO October 15, 2001 Stephanie Overby |
Drug Companies on speed The marriage of IT and medical research may be just what traditional pharmaceutical companies need to survive in an increasingly competitive field. Learn how IT is bringing the pharmaceutical industry into the information age...  |
Bio-IT World December 15, 2003 Zachary Zimmerman |
Learning the Language of Systems Biology Geneticist par excellence David Botstein talks about his philosophy, science, his mission for integrative science, and what he deems a success for systems biology.  |
Pharmaceutical Executive February 1, 2006 Ron Feemster |
Gene Logic: Rescue Squad One or two late-stage clinical failures can land promising drug candidates on the shelf. Forever? Maybe not. Gene Logic tests Big Pharma's dead drugs for hundreds of different targets.  |
Bio-IT World May 9, 2003 Vivien Marx |
The Sharper Image See it, capture it, mine it, find it. The budding field of image informatics is empowering biomedical research.  |
Bio-IT World July 11, 2002 Malorye Branca |
Deep Sequence Diving Like sailors of old, genomic data miners dream of discovering riches and fame. Given the recent improvements in analytics -- and a little more time -- they just might succeed.  |
Bio-IT World July 14, 2004 Malorye A. Branca |
The Pathways Promise By using the right tools, even a modest genomic data set can generate a good view into a particular biological pathway. Now, a range of new technologies is arising from academia as well as the commercial sector to meet this need.  |
Bio-IT World April 15, 2003 Mark D. Uehling |
Target Elimination Industry and FDA scientists turn to databases, applications software, and laboratory chips to move the safest, most effective molecules into clinical trials.  |
Bio-IT World December 15, 2003 Malorye A. Branca |
Scenes from a Cell Breakthroughs are making cell-based screening faster, easier, more powerful.  |
Bio-IT World November 14, 2003 Jeff Augen |
Making Information-Based Medicine Work A confluence of scientific discovery and high-throughput technology has made information-based medicine possible -- and imperative.  |
Bio-IT World May 19, 2004 John Russell |
Informatics Black Boxes ... Not! Vertex's chief technical officer, discusses informatics' bad reputation, buying vs. building, open-source tools, and ROI on IT.  |
Bio-IT World September 2006 Mike May |
Working Out the Flow Better management of workflow issues in biotech and pharma could change fundamental aspects of these sciences in the near future.  |
Bio-IT World September 2006 John A. Wass |
Integrating Knowledge The results of new mathematical routines have the potential to save pharmaceuticals millions of dollars in drug development. And yet the flow of successful drugs is dwindling. The problem goes beyond bureaucracy and lies in the complexity of the problem.  |
Bio-IT World June 2006 Kevin Davies |
The Data Deluge: Deal or No Deal? Far from decrying the data glut, researchers should embrace the complexity of genomic and other sources of data, particularly for its predictive properties in the field of personalized medicine.  |
Bio-IT World November 12, 2002 James Golden |
The Business of Bioinformatics The industry has reached an interesting crossroads. As an academic branch of learning, bioinformatics remains mostly what it always was, a cross-disciplinary endeavor between computer science and molecular biology. But bioinformatics as a money-making proposition has different criteria for success.  |
Bio-IT World March 10, 2003 Mark D. Uehling |
Technology Overload Inundated with new IT tools and mountains of data, the pharmaceutical industry struggles to pull it all together.  |
Bio-IT World October 10, 2003 Donna Mendrick |
Microarrays That Make Drugs Safe Using DNA chips to discover potential toxicity in new drug compounds -- a key application of toxicogenomics -- can predict adverse effects before they occur, enabling safer clinical trials.  |
Bio-IT World January 21, 2005 Salvatore Salamone |
A Prescription for Information-Based Medicine TurboWorx president and CEO Jeff Augen not only combines computational and biology expertise, but also has a clear vision of how to advance life science discovery.  |
Salon.com May 1, 2000 Arthur Allen |
Listening to DNA The genome project is getting the buzz. But the real breakthroughs may come from labs out of the limelight, like Gene Logic.  |
Bio-IT World September 16, 2004 Michael A. Greeley |
Platforms for Pathways Investor interest in the next great blockbuster drug has been blistering hot; Phase II and Phase III compound companies are being funded at a near record-breaking pace now that the IPO window seems to be slightly open  |
Pharmaceutical Executive July 1, 2005 Zaborowski, Hammer & Lawler |
Informatics Rules How global computer systems helped far-flung research centers at Roche work together  |
Bio-IT World November 2006 Kevin Davies |
Compute for the Cure Computational comparison offers a seductive new approach to identify new drugs for disease, as well as re-purposing existing drugs.  |
Bio-IT World February 10, 2003 Salvatore Salamone |
Made in Manhattan A talk with the new head of the Computational Biology Center at Memorial Sloan-Kettering.  |
Bio-IT World September 9, 2002 John P. Helfrich |
Data Management in High-Throughput Screening The high-throughput drug discovery field requires an optimal IT platform.  |
Bio-IT World March 10, 2003 Richard Dweck |
Sifting Through Standards Standards in informatics can sometimes raise more questions than they answer. Take a pragmatic approach.  |
Bio-IT World October 10, 2003 Mark D. Uehling |
Digging Into Digital Quarries Industrial-strength software is helping discover unexpected connections in the scientific literature.  |
Industrial Physicist Apr/May 2003 Jennifer Oullette |
Switching from physics to biology Physicists in transition help shape biological theory.  |
Bio-IT World November 2006 Kevin Davies |
Building a Bridge Over Pharma with IT More than 100 enthusiastic delegates bridging the full breadth of the drug development pipeline gathered recently for the second annual Bridging Pharma and IT conference. Here are some highlights.  |
Bio-IT World September 2006 John Russell |
Informatics Cornucopia Predictive Informatics, the hopeful title of a session at last month's Drug Discovery Technology & Development World Congress, remains an enticing but mostly elusive goal. Asked what systems biology would look in five years and what will constitute success, panelists offered the following.  |
Bio-IT World June 12, 2002 Beth Schachter |
Informatics Moves to the Head of the Class The race is on to increase the quantity and quality of bio-IT training programs as government and academia bet the need will be great. Will the job market back up that bet?  |
Bio-IT World April 2007 Leach & Tedeschi |
If THEY Build It, THEY Will Come Biopharma companies have many lessons to learn from the emerging and maturing Web 2.0 technologies. While social networking will help foster the exchange of ideas, sharing data remains one of the biopharma industry's greatest challenges.  |
Bio-IT World February 18, 2004 |
Proteomics Goes Cellular Tissue microarrays save big on sample material and reagents. But more importantly, this new high-throughput technology is helping save the lives of cancer patients  |
Bio-IT World September 9, 2002 |
Letters Frustrated in Gene Town... IT for the Biologists, by the Biologists?...  |
Bio-IT World July 11, 2002 Stephen T.C. Wong |
Neuro-IT Needs Integrated Infrastructure There are two major motivations for merging enterprise solutions into clinical neuroscience. The first is the need to scale up the capacity for data management. The second is the economic benefits of data sharing, software reuse, and infrastructure build-out while reducing costs.  |
Bio-IT World October 9, 2002 Malorye Branca |
The Path to Personalized Medicine The tactics have changed, sometimes dramatically, but hints of the promise of pharmacogenomics are finally starting to trickle in from studies of asthma, cancer, and drug response.  |
Bio-IT World May 7, 2002 Malorye Branca |
In Silico Survivors Facing desperate times, bioinformatics companies revamp, refocus, or perish.  |
HHMI Bulletin Aug 2010 Sarah C.P. Williams |
Fruit Fly Cells Don't All Know What Sex They Are HHMI scientists have now found that many cells in male and female fruit flies not only look the same, they are more identical at a molecular level than was previously thought.  |
Bio-IT World November 2005 |
Bridges and Boundaries in Drug Discovery Research Good communication, blurring cultural boundaries, and strong project governance may be as, if not more, important as sweeping technology solutions when it comes to converging discovery and IT and expediting drug development.  |
Bio-IT World September 2006 Nat Goodman |
Getting a Handle on Systems Biology Systems biology is squarely an experimental field that eats, drinks, and breathes data. To do systems biology, you need an experimental system that is amenable to large-scale experimentation.  |
Bio-IT World June 17, 2004 John Russell |
Systems Biology - Now Leaving on Track 1 Entelos, a leader in predictive biosimulation, partners with pharmaceutical and biotech organizations worldwide to develop effective new treatments for disease. Michael French, chief business officer at Entelos, explains what powers the systems biology engine.  |
Bio-IT World December 15, 2004 William Marshall |
Applications of RNAi RNA interference is a highly coordinated gene regulatory mechanism that appears to be highly conserved across all metazoans studied thus far.  |
Bio-IT World October 14, 2004 William Pulleyblank |
Rewriting the Rulebook for Supercomputing and Research IBM's Blue Gene supercomputer project leader highlights progress and future applications.  |
Bio-IT World April 2007 Vicki Glaser |
Software Solutions for Medicinal Chemistry Driven by advances in chemical synthesis, instrumentation, and high-throughput and high-content screening technology, medicinal chemistry's transition from an art to a science is benefiting from a wealth of new software products, spanning both bio- and cheminformatics.  |
Bio-IT World March 10, 2003 Salvatore Salamone |
Common Knowledge Two heads (or more) are better than one, except when they don't share information. That's where knowledge management comes in.  |
Chemistry World May 17, 2006 Bea Perks |
Biochemists Reveal Hidden Drug Effects Researchers have identified unexpected drug activities by probing biochemical pathways inside living cells.  |